scholarly journals Potential role for lipopolysaccharide in congenital sensorineural hearingloss

2010 ◽  
Vol 59 (4) ◽  
pp. 377-383 ◽  
Author(s):  
A. L. Smit ◽  
R. J. Stokroos ◽  
S. G. H. Litjens ◽  
B. Kremer ◽  
B. W. Kramer
Keyword(s):  
Hearing Loss ◽  
Comparative Analysis ◽  
Sensorineural Hearing Loss ◽  
Genetic Factors ◽  
Potential Role ◽  
Experimental Studies ◽  
Intrauterine Infection ◽  
Live Births ◽  
Inner Ear Damage

Congenital sensorineural hearing loss (SNHL) is common. In theWestern world, the incidence is 1–3 per 1000 live births. The aetiologyencompasses genetic and non-genetic factors accounting for 55 %and 45 % of cases, respectively. Reports that describe the contributionof intrauterine infection to the occurrence of congenital SNHL are limited,and comparative analysis of the different pathogens is lacking. Lipopolysaccharide (LPS),a product of bacteriolysis, has been demonstrated to be associated with innerear damage in experimental studies. To elucidate the potential role of thistoxin in congenital SNHL and to identify the pathogenesis and transmissionroutes, we reviewed the literature. We speculate that different routes ofexposure to LPS in utero may result in congenital inner ear damage.

A Critical Role of the Insula in Sensorineural Hearing Loss

2018 ◽  
Author(s):  
Xiao-Min Xu ◽  
Yun Jiao ◽  
Tianyu Tang ◽  
Jian Zhang ◽  
Chunqiang Lu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Critical Role ◽  
Sensorineural Hearing

Role of ciclosporin in steroid-responsive sudden sensorineural hearing loss

2005 ◽  
Vol 125 (12) ◽  
pp. 1356-1360 ◽  
Author(s):  
Lisha McClelland ◽  
Richard J. Powell ◽  
John Birchall
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

Functional outcome after intracerebral haemorrhage – a review of the potential role of antiapoptotic agents

2016 ◽  
Vol 27 (3) ◽  
pp. 317-327 ◽  
Author(s):  
Abubakar Tijjani Salihu ◽  
Sangu Muthuraju ◽  
Zamzuri Idris ◽  
Abdul Rahman Izaini Ghani ◽  
Jafri Malin Abdullah
Keyword(s):  
Functional Outcome ◽  
Intracerebral Haemorrhage ◽  
Neuronal Death ◽  
Potential Role ◽  
Management Strategies ◽  
Experimental Studies ◽  
Neuronal Loss ◽  
Multimodality Treatment ◽  
Mortality And Morbidity

AbstractIntracerebral haemorrhage (ICH) is the second most common form of stroke and is associated with greater mortality and morbidity compared with ischaemic stroke. The current ICH management strategies, which mainly target primary injury mechanisms, have not been shown to improve patient’s functional outcome. Consequently, multimodality treatment approaches that will focus on both primary and secondary pathophysiology have been suggested. During the last decade, a proliferation of experimental studies has demonstrated the role of apoptosis in secondary neuronal loss at the periphery of the clot after ICH. Subsequently, the value of certain antiapoptotic agents in reducing neuronal death and improving functional outcome following ICH was evaluated in animal models. Preliminary evidence from those studies strongly supports the potential role of antiapoptotic agents in reducing neuronal death and improving functional outcome after intracerebral haemorrhage. Expectedly, the ongoing and subsequent clinical trials will substantiate these findings and provide clear information on the most potent and safe antiapoptotic agents, their appropriate dosage, and temporal window of action, thereby making them suitable for the multimodality treatment approach.

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