scholarly journals A case of bilateral microsporidial keratitis from Bangladesh – infection by an insect parasite from the genus Nosema

2007 ◽  
Vol 56 (9) ◽  
pp. 1250-1252 ◽  
Author(s):  
Alan Curry ◽  
Hardeep Singh Mudhar ◽  
Sumedh Dewan ◽  
Elizabeth U. Canning ◽  
Bart E. Wagner
Keyword(s):  
Immune Status ◽  
Mosquito Larvae ◽  
Microsporidian Parasite ◽  
Negative Patient ◽  
Insect Parasite ◽  
Ocular Symptoms ◽  
Rural Pond ◽  
Reduced Temperature ◽  
Insect Parasites ◽  
Hiv Negative

An HIV-negative patient from Bangladesh with bilateral keratitis was found to be infected with a microsporidian parasite belonging to the genus Nosema. Significantly, the patient had bathed in a rural pond 7 days prior to the development of ocular symptoms. Nosema parasites are common insect parasites and the source of this microsporidial infection was possibly from mosquito larvae developing in the pond in which the patient bathed. The reduced temperature of the human eye and its immune status may have allowed a poikilothermic insect parasite to establish infection in the cornea of a homeothermic human host. This case highlights the opportunistic potential of insect microsporidial parasites to infect immunocompetent humans as well as those who are immunodeficient.

scholarly journals Disseminated form of the Kaposi sarcoma in HIV-negative patient associated with Hodgkin’s lymphoma

2020 ◽  
Vol 2020 (9) ◽  
Author(s):  
V V Tutaeva ◽  
A N Bobin ◽  
M R Ovsiannikova ◽  
M V Bulgakova ◽  
Y M Kuchma ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Immune Status ◽  
Kaposi Sarcoma ◽  
Lymphoproliferative Disorders ◽  
Hodgkin's Lymphoma ◽  
Herpes Viruses ◽  
Infected Male ◽  
Negative Patient ◽  
Abvd Chemotherapy ◽  
Hiv Negative

ABSTRACT We report a case of a 35-year-old, non-HIV-infected male diagnosed simultaneously with a disseminated form of Kaposi’s sarcoma (KS; skin, stomach and colon are involved) and Hodgkin’s lymphoma. There is no sign of changes in the immune status, but three herpes viruses were detected in the patient’s blood (EBV, HHV6 and HHV8). He received ABVD chemotherapy and achieved complete metabolic remission for Hodgkin’s lymphoma. Moreover, the signs of the disseminated KS were resolved. Our observations indicate that a combination of distinct types of viruses may play an important role in triggering the development of angio- and lymphoproliferative disorders in the same person. In addition, treatment with chemotherapy cycles, which included doxorubicin and vinblastine, led to the stable remission of both diseases.

scholarly journals First report of cryptococcosis due to Cryptococcus gattii sensu stricto VGI in an Ivorian HIV negative patient

2021 ◽  
Vol 31 (2) ◽  
pp. 101113
Author(s):  
V. Bellet ◽  
F.K. Kassi ◽  
D. Krasteva ◽  
F. Roger ◽  
P. Drakulovski ◽  
...  
Keyword(s):  
Sensu Stricto ◽  
Cryptococcus Gattii ◽  
Negative Patient ◽  
First Report ◽  
Hiv Negative

scholarly journals HIV-negative case of Talaromyces marneffei pulmonary infection with a TSC2 mutation

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110167
Author(s):  
Qian Shen ◽  
Lingyan Sheng ◽  
Jianying Zhou
Keyword(s):  
Pulmonary Infection ◽  
Pathogenic Fungus ◽  
Critical Role ◽  
Lavage Fluid ◽  
Tsc2 Gene ◽  
Current Case ◽  
Negative Patient ◽  
Talaromyces Marneffei ◽  
Negative Case ◽  
Hiv Negative

Talaromyces marneffei is a rare dimorphic pathogenic fungus that can induce severe infections in human immunodeficiency virus (HIV)-infected patients. However, such infections have also been reported in non-HIV hosts. This current case report describes a very rare case of a T. marneffei pulmonary infection in an HIV-negative patient with a mutation in the tuberous sclerosis complex subunit 2 ( TSC2) gene. A 24-year-old male patient presented with cough and expectoration for 6 months. Computed tomography showed multiple ground-glass opacities and cystic and cavitated lesions in both lungs. Next generation sequencing (NGS) of the bronchoalveolar lavage fluid was performed to confirm T. marneffei pulmonary infection. The results were further verified using bronchoscopy specimen cultures. This was an HIV-negative patient without a travel history to endemic zones and his blood exon sequencing results showed a mutation in the TSC2 gene. To date, he has recovered well with voriconazole therapy. In summary, patients with TSC2 mutations that induce bronchopulmonary dysplasia may be potential hosts for T. marneffei. Early and timely diagnosis is important for improving prognosis. NGS plays a critical role in the diagnosis of T. marneffei pulmonary infection.

scholarly journals Cryptococcal granulomas in an immunocompromised HIV-negative patient

2008 ◽  
Vol 51 (4) ◽  
pp. 553 ◽  
Author(s):  
Juhi Taneja ◽  
Aradhana Bhargava ◽  
Poonam Loomba ◽  
Vinita Dogra ◽  
Archana Thakur ◽  
...  
Keyword(s):  
Negative Patient ◽  
Hiv Negative
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