Effects of powder mixtures containing ark shell on IgE-mediated
                        allergic response in RBL-2H3 cells

The term hypersensitivity refers to diseases caused by an immune response, regardless of whether the response is against a pathogen, nonpathogen, or self and regardless of whether the response is directed by antibodies, lymphocytes, or innate pathways. The term anaphylaxis was coined in 1902 by Charles Richet, who received the Nobel Prize in 1913; this systemic allergic response is now known to be an immediate hypersensitivity reaction, initiated by allergen delivered to a host having allergen-specific IgE, thereby causing an IgE-mediated immunologic response and activating mast cells and basophils to secrete bioactive mediators. In 2005, the National Institutes of Health organized a consensus conference to develop a working definition of anaphylaxis, designed to be used by physicians at the bedside, as a serious allergic reaction that is rapid in onset, typically eliciting various combinations of cutaneous, cardiovascular, respiratory, and gastrointestinal manifestations, and may cause death.1,2 This facilitated the early treatment of such patients with epinephrine. Confusion arises over the misapplication of the term allergy or hypersensitivity to describe any untoward reaction to food, medications, or environmental exposures. Furthermore, non–IgE-mediated forms of local and systemic mast cell or basophil activation events can occur, causing signs and symptoms similar to those mediated by IgE. This review contains 3 figures, 9 tables, and 62 references. Keywords: allergy, hypersensitivity, anaphylaxis, interleukin, chemokines, immunoglobulin E, mast cell, eosinophil

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Evolutionary background of allergic reactivity: mast cells, FcεRI, IgE - three components of the effector phase of the allergic response

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja131 ◽

2018 ◽

Vol 15 (4) ◽

pp. 5-16

Author(s):

I S Gushchin

Keyword(s):

Mast Cells ◽

Immunoglobulin E ◽

The Body ◽

Allergic Response ◽

Effector Phase ◽

Time Regime ◽

High Affinity Receptor ◽

Ige Mediated ◽

Affinity Receptor ◽

Elimination Function

The literature data on the evolution of the main obligatory participants in the effector phase of the IgE-mediated allergic response are presented: mast cells/basophils, immunoglobulin E, and high affinity receptor for the Fcε fragment (FcεRI). Allergic reactivity is considered as the most recent evolutionary immunologically-mediated acquisition of mammals. It is aimed at recognizing small amounts of allergen entering the body in a certain time regime, and organizing an allergen-specific inflammation that carries features of elimination function. The most biologically justified way to prevent allergies is to restore the function of barrier systems and, accordingly, to prevent the need to develop an allergic response.

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Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

Nutrients ◽

10.3390/nu12103193 ◽

2020 ◽

Vol 12 (10) ◽

pp. 3193

Author(s):

Bilal Alashkar Alhamwe ◽

Laura A. P. M. Meulenbroek ◽

Désirée H. Veening-Griffioen ◽

Tjalling M. D. Wehkamp ◽

Fahd Alhamdan ◽

...

Keyword(s):

Gene Expression ◽

Food Allergy ◽

Histone Acetylation ◽

Specific Ige ◽

Allergic Response ◽

Cow’S Milk ◽

Milk Allergy ◽

T Helper ◽

Cow's Milk ◽

Ige Mediated

Immunoglobulin E (IgE)-mediated allergy against cow’s milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis of allergies. However, its role in food allergy remains unknown. IgE-mediated cow’s milk allergy was successfully induced in a mouse model, as demonstrated by acute allergic symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge with whey protein. The elicited allergic response coincided with reduced percentages of regulatory T (Treg) and T helper 17 (Th17) cells, matching decreased levels of H3 and/or H4 histone acetylation at pivotal Treg and Th17 loci, an epigenetic status favoring lower gene expression. In addition, histone acetylation levels at the crucial T helper 1 (Th1) loci were decreased, most probably preceding the expected reduction in Th1 cells after inducing an allergic response. No changes were observed for T helper 2 cells. However, increased histone acetylation levels, promoting gene expression, were observed at the signal transducer and activator of transcription 6 (Stat6) gene, a proallergic B cell locus, which was in line with the presence of whey-specific IgE. In conclusion, the observed histone acetylation changes are pathobiologically in line with the successful induction of cow’s milk allergy, to which they might have also contributed mechanistically.

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Thymoquinone attenuates IgE‐mediated allergic response via pi3k‐Akt‐NFκB pathway and upregulation of the Nrf2‐HO1 axis

Journal of Food Biochemistry ◽

10.1111/jfbc.13216 ◽

2020 ◽

Vol 44 (6) ◽

Author(s):

Ayed Dera ◽

Prasanna Rajagopalan ◽

Irfan Ahmed ◽

Mohammad Alfhili ◽

Jawaher Alsughayyir ◽

...

Keyword(s):

Allergic Response ◽

Ige Mediated ◽

Nfκb Pathway

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Mast Cell-Mediated Allergic Response Is Suppressed by Sophorae Flos: Inhibition of Src-Family Kinase

Experimental Biology and Medicine ◽

10.3181/0803-rm-89 ◽

2008 ◽

Vol 233 (10) ◽

pp. 1271-1279 ◽

Cited By ~ 7

Author(s):

Jun Ho Lee ◽

Jie Wan Kim ◽

Na Young Ko ◽

Se Hwan Mun ◽

Do Kyun Kim ◽

...

Keyword(s):

Mast Cells ◽

Map Kinases ◽

Herbal Medicines ◽

Inhibitory Effect ◽

Allergic Response ◽

Src Family Kinase ◽

Potent Effect ◽

Alternative Medicines ◽

Ige Mediated

Complementary and alternative medicines are considered as a promising direction for the development of anti-allergic therapies in oriental countries. We screened approximately 100 oriental herbal medicines for anti-allergic activity. Sophorae flos exhibited the most potent effect on degranulation in antigen-stimulated mast cells. We further investigated the effect of Sophorae flos on the IgE-mediated allergic response in vivo and its mechanism of action in mast cells. Sophorae flos exhibited a significant inhibitory effect on degranulation in antigen-stimulated mast cells with IC50 values of ~31.6 μg/mL (RBL-2H3 mast cells) and ~47.8 μg/mL (bone marrow-derived mast cells). Sophorae flos also suppressed the expression and secretion of TNF-α and IL-4 in the cells and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Sophorae flos inhibited the activating phosphorylation of Syk and LAT in mast cells. Further downstream, activating phosphorylation of Akt and the prototypic MAP kinases, namely, p38, ERK1/2, and JNK, were also inhibited. These results suggest that Sophorae flos inhibits the Src family kinase-dependent signaling cascades in mast cells and may thus exert anti-allergic activity.

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Houttuynia cordata water extract suppresses anaphylactic reaction and IgE-mediated allergic response by inhibiting multiple steps of FcεRI signaling in mast cells

Food and Chemical Toxicology ◽

10.1016/j.fct.2009.04.025 ◽

2009 ◽

Vol 47 (7) ◽

pp. 1659-1666 ◽

Cited By ~ 27

Author(s):

Eun Hee Han ◽

Jin Hee Park ◽

Ji Young Kim ◽

Hye Gwang Jeong

Keyword(s):

Mast Cells ◽

Anaphylactic Reaction ◽

Water Extract ◽

Allergic Response ◽

Houttuynia Cordata ◽

Ige Mediated

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Allergic Response

10.2310/im.1232 ◽

2019 ◽

Author(s):

Joud Hajjar ◽

Lawrence B Schwartz

Keyword(s):

Mast Cell ◽

Immunoglobulin E ◽

Signs And Symptoms ◽

Specific Ige ◽

Consensus Conference ◽

Allergic Response ◽

Working Definition ◽

Keywords Allergy ◽

Ige Mediated ◽

Definition Of

The term hypersensitivity refers to diseases caused by an immune response, regardless of whether the response is against a pathogen, nonpathogen, or self and regardless of whether the response is directed by antibodies, lymphocytes, or innate pathways. The term anaphylaxis was coined in 1902 by Charles Richet, who received the Nobel Prize in 1913; this systemic allergic response is now known to be an immediate hypersensitivity reaction, initiated by allergen delivered to a host having allergen-specific IgE, thereby causing an IgE-mediated immunologic response and activating mast cells and basophils to secrete bioactive mediators. In 2005, the National Institutes of Health organized a consensus conference to develop a working definition of anaphylaxis, designed to be used by physicians at the bedside, as a serious allergic reaction that is rapid in onset, typically eliciting various combinations of cutaneous, cardiovascular, respiratory, and gastrointestinal manifestations, and may cause death.1,2 This facilitated the early treatment of such patients with epinephrine. Confusion arises over the misapplication of the term allergy or hypersensitivity to describe any untoward reaction to food, medications, or environmental exposures. Furthermore, non–IgE-mediated forms of local and systemic mast cell or basophil activation events can occur, causing signs and symptoms similar to those mediated by IgE. This review contains 3 figures, 9 tables, and 62 references. Keywords: allergy, hypersensitivity, anaphylaxis, interleukin, chemokines, immunoglobulin E, mast cell, eosinophil

Download Full-text