scholarly journals Changing trends in proportional incidence and net survival of screened and nonscreened breast cancers among women in England

2019 ◽  
Author(s):  
Haiyan Wu ◽  
Kwok Wong ◽  
Shou-En Lu ◽  
John Broggio ◽  
Lanjing Zhang
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Invasive Breast Cancer ◽  
Temporal Trends ◽  
Breast Cancers ◽  
Upward Trend ◽  
Net Survival ◽  
Survival Difference ◽  
Proportional Incidence

AbstractBackgroundUptake of breast cancer screening has been decreasing in England since 2007, and may increase proportional incidence of nonscreened cancers. However, recent trends in proportional incidence and net-survivals of screened and nonscreened breast cancers are unclear.MethodsWe extracted population-based proportional incidence and age-standardized 5-year net-survivals from Public Health England, for English women with invasive breast cancer diagnosed during 1995-2011 (linked to death certificates, followed through 2016). Piecewise log-linear models with change-point/joinpoint were used to estimate temporal trends. We conducted a quasi-experimental study to test the hypothesis that the trend-change year of proportional incidence coincided with that of 5-year net-survival.ResultsAmong 254,063 women in England with invasive breast cancer diagnosed during 1995-2011, there was downward-to-upward trend-change in proportional incidence of nonscreened breast cancers (annual percent change[APC]=5.6 after 2007 versus APC=-3.5 before 2007, P<0.001) in diagnosis-year 2007, when steeper upward-trend in age-standardized 5-year net survival started (APC=5.7 after 2007/2008 versus APC=0.3 before 2007/2008, P<0.001). Net-survival difference of screened versus nonscreened cancers also significantly narrowed (18% in 2007/2008 versus 5% in 2011). Similar associations were found in all strata of race, cancer stage, grade and histology, except in Black patients or patients with stage I, stage III, or grade I cancer.ConclusionsThe downward-to-upward trend-change in proportional incidence of nonscreened breast cancers is associated with steeper upward-trend in age-standardized 5-year net survival among English women in recent years. Survival benefits of breast cancer screening appear decreasing in recent years. The data support reduction of breast cancer screening in some patients.

Investigating the breast cancer screening–treatment–mortality pathway of women diagnosed with invasive breast cancer: Results from linked health data

2021 ◽  
Author(s):  
Ming Li ◽  
Michelle Reintals ◽  
Katina D'Onise ◽  
Gelareh Farshid ◽  
Andrew Holmes ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Invasive Breast Cancer ◽  
Health Data ◽  
Treatment Mortality

Abstract P4-05-07: Molecular profiles of screen detected breast cancers: Final results of Turkish Bahcesehir breast cancer screening project

2013 ◽  
Author(s):  
N Cabioglu ◽  
S Ozkan-Gurdal ◽  
A Kayhan ◽  
N Ozaydin ◽  
B Ozcinar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Breast Cancers ◽  
Molecular Profiles

Phenotypic characterization and risk factors for interval breast cancers in a population-based breast cancer screening program in Barcelona, Spain

2010 ◽  
Vol 21 (8) ◽  
pp. 1155-1164 ◽  
Author(s):  
Laia Domingo ◽  
Maria Sala ◽  
Sònia Servitja ◽  
Josep Maria Corominas ◽  
Francisco Ferrer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Screening Program ◽  
Population Based ◽  
Phenotypic Characterization ◽  
Breast Cancers ◽  
Breast Cancer Screening Program ◽  
Cancer Screening Program

scholarly journals Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahçeşehir (Istanbul) Breast Cancer Screening Project in Turkey

2020 ◽  
pp. 1103-1113
Author(s):  
Neslihan Cabioğlu ◽  
Sibel Özkan Gürdal ◽  
Arda Kayhan ◽  
Nilüfer Özaydın ◽  
Cennet Şahin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Triple Negative ◽  
Long Term Results ◽  
Breast Cancers ◽  
Interval Cancers ◽  
Luminal A ◽  
Ki 67 ◽  
Luminal B

PURPOSE The Turkish Bahçeşehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahçeşehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5%) were detected. The majority of patients (82.3%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 15; 11.4%) were more likely to have a worse prognostic stage (II-IV disease; odds ratio [OR], 3.59, 95% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.14; 95% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1% v 31.9%) and triple-negative (14.3% v 1%) subtype and less likely to have a luminal A subtype (28.6% v 61.5%; P = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2% v 98.1%, P = .002; DFS: 78.6% v 96.5%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies.

Characteristics of invasive breast cancer and overall survival of patients eligible for mass breast cancer screening in Guadeloupe compared to those of the preceding age group

2017 ◽  
Vol 50 ◽  
pp. 268-271 ◽  
Author(s):  
Philippe Kadhel ◽  
Daphné Borja De Mozota ◽  
Stéphanie Gaumond ◽  
Jacqueline Deloumeaux
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Invasive Breast Cancer ◽  
Age Group

scholarly journals Overcoming Overdiagnosis: Women´s Preferences for Improving Breast Cancer Screening

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 38s-38s
Author(s):  
H.L. Bromley ◽  
T.E. Roberts ◽  
D. Petrie ◽  
B.G. Mann ◽  
D. Rea ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Ductal Carcinoma ◽  
Low Risk ◽  
Breast Cancers ◽  
Active Monitoring ◽  
The Impact

Background: Breast cancer screening is effective in reducing breast cancer mortality, but there is increasing concern that it may also lead to overdiagnosis; the detection and treatment of a cancer that would never have presented symptomatically during the woman's lifetime. Conservative management of low-risk breast cancer may reduce the harm of overdiagnosis resulting from mammographic screening programs, yet little is known about how such strategies might impact upon quality of life. Aim: To quantify women's preferences for managing low risk breast cancers identified by breast cancer screening. Methods: Utilities (measures of preference) were obtained from women with and without a history of breast cancer for seven health states reflecting low risk screen detected ductal carcinoma in situ (DCIS) using standard gambles. Demographics and a history of prior screening participation or breast cancer diagnosis were examined as predictors of screening and treatment pathway preferences. Results: Utilities were lower for breast cancers treated with mastectomy or invasive adjuvant treatment. The impact of active monitoring on quality of life was comparable to breast conserving surgery, although women in both patient and general population groups rated active monitoring more favorably as the risk of disease spread was decreased. There was some variation in ratings across patients suggesting that individual risk aversion does affect preferences for the type of conservative management valued. Conclusion: Overdiagnosis remains a challenge for improving the current breast cancer screening program. Active monitoring of low risk ductal carcinoma in situ may provide an acceptable solution for reducing the impact of overdiagnosis and overtreatment resulting from breast cancer screening on quality of life.

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