scholarly journals Machine Learning Algorithms for Predicting Coronary Artery Disease: Efforts Toward an Open Source Solution

Author(s):  
Aravind Akella ◽  
Vibhor Kaushik

AbstractThe development of Coronary Artery Disease (CAD), one of the most prevalent diseases in the world, is heavily influenced by several modifiable risk factors. Predictive models built using machine learning (ML) algorithms may assist healthcare practitioners in timely detection of CAD, and ultimately, may improve outcomes. In this study, we have applied six different ML algorithms to predict the presence of CAD amongst patients listed in an openly available dataset provided by the University of California Irvine (UCI) Machine Learning Repository, named “the Cleveland dataset.” All six ML algorithms achieved accuracies greater than 80%, with the “Neural Network” algorithm achieving accuracy greater than 93%. The recall achieved with the “Neural Network” model is also highest of the six models (0.93). Additionally, five of the six algorithms resulted in very similar AUC-ROC curves. The AUC-ROC curve corresponding to the “Neural Network” algorithm is slightly steeper implying higher “true positive percentage” achieved with this model. We also extracted the variables of importance in the “Neural Network” model to help in the risk assessment. We have released the full computer code generated in this study in the public domain as a preliminary effort toward developing an open solution for predicting the presence of coronary artery disease in a given population and present a workflow model for implementing a possible solution.

2021 ◽  
pp. FSO698
Author(s):  
Aravind Akella ◽  
Sudheer Akella

Aim: The development of coronary artery disease (CAD), a highly prevalent disease worldwide, is influenced by several modifiable risk factors. Predictive models built using machine learning (ML) algorithms may assist clinicians in timely detection of CAD and may improve outcomes. Materials & methods: In this study, we applied six different ML algorithms to predict the presence of CAD amongst patients listed in ‘the Cleveland dataset.’ The generated computer code is provided as a working open source solution with the ultimate goal to achieve a viable clinical tool for CAD detection. Results: All six ML algorithms achieved accuracies greater than 80%, with the ‘neural network’ algorithm achieving accuracy greater than 93%. The recall achieved with the ‘neural network’ model is also the highest of the six models (0.93), indicating that predictive ML models may provide diagnostic value in CAD.


2020 ◽  
Vol 15 ◽  
Author(s):  
Elham Shamsara ◽  
Sara Saffar Soflaei ◽  
Mohammad Tajfard ◽  
Ivan Yamshchikov ◽  
Habibollah Esmaili ◽  
...  

Background: Coronary artery disease (CAD) is an important cause of mortality and morbidity globally. Objective : The early prediction of the CAD would be valuable in identifying individuals at risk, and in focusing resources on its prevention. In this paper, we aimed to establish a diagnostic model to predict CAD by using three approaches of ANN (pattern recognition-ANN, LVQ-ANN, and competitive ANN). Methods: One promising method for early prediction of disease based on risk factors is machine learning. Among different machine learning algorithms, the artificial neural network (ANN) algo-rithms have been applied widely in medicine and a variety of real-world classifications. ANN is a non-linear computational model, that is inspired by the human brain to analyze and process complex datasets. Results: Different methods of ANN that are investigated in this paper indicates in both pattern recognition ANN and LVQ-ANN methods, the predictions of Angiography+ class have high accuracy. Moreover, in CNN the correlations between the individuals in cluster ”c” with the class of Angiography+ is strongly high. This accuracy indicates the significant difference among some of the input features in Angiography+ class and the other two output classes. A comparison among the chosen weights in these three methods in separating control class and Angiography+ shows that hs-CRP, FSG, and WBC are the most substantial excitatory weights in recognizing the Angiography+ individuals although, HDL-C and MCH are determined as inhibitory weights. Furthermore, the effect of decomposition of a multi-class problem to a set of binary classes and random sampling on the accuracy of the diagnostic model is investigated. Conclusion : This study confirms that pattern recognition-ANN had the most accuracy of performance among different methods of ANN. That’s due to the back-propagation procedure of the process in which the network classify input variables based on labeled classes. The results of binarization show that decomposition of the multi-class set to binary sets could achieve higher accuracy.


Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1446
Author(s):  
Tanyaporn Pattarabanjird ◽  
Corban Cress ◽  
Anh Nguyen ◽  
Angela Taylor ◽  
Stefan Bekiranov ◽  
...  

Background: Machine learning (ML) has emerged as a powerful approach for predicting outcomes based on patterns and inferences. Improving prediction of severe coronary artery disease (CAD) has the potential for personalizing prevention and treatment strategies and for identifying individuals that may benefit from cardiac catheterization. We developed a novel ML approach combining traditional cardiac risk factors (CRF) with a single nucleotide polymorphism (SNP) in a gene associated with human CAD (ID3 rs11574) to enhance prediction of CAD severity; Methods: ML models incorporating CRF along with ID3 genotype at rs11574 were evaluated. The most predictive model, a deep neural network, was used to classify patients into high (>32) and low level (≤32) Gensini severity score. This model was trained on 325 and validated on 82 patients. Prediction performance of the model was summarized by a confusion matrix and area under the receiver operating characteristics curve (ROC-AUC); and Results: Our neural network predicted severity score with 81% and 87% accuracy for the low and the high groups respectively with an ROC-AUC of 0.84 for 82 patients in the test group. The addition of ID3 rs11574 to CRF significantly enhanced prediction accuracy from 65% to 81% in the low group, and 72% to 84% in the high group. Age, high-density lipoprotein (HDL), and systolic blood pressure were the top 3 contributors in predicting severity score; Conclusions: Our neural network including ID3 rs11574 improved prediction of CAD severity over use of Framingham score, which may potentially be helpful for clinical decision making in patients at increased risk of complications from coronary angiography.


2019 ◽  
Vol 24 (2) ◽  
pp. 217-230
Author(s):  
Olalekan Shamsideen Oshodi ◽  
Wellington Didibhuku Thwala ◽  
Tawakalitu Bisola Odubiyi ◽  
Rotimi Boluwatife Abidoye ◽  
Clinton Ohis Aigbavboa

Purpose Estimation of the rental price of a residential property is important to real estate investors, financial institutions, buyers and the government. These estimates provide information for assessing the economic viability and the tax accruable, respectively. The purpose of this study is to develop a neural network model for estimating the rental prices of residential properties in Cape Town, South Africa. Design/methodology/approach Data were collected on 14 property attributes and the rental prices were collected from relevant sources. The neural network algorithm was used for model estimation and validation. The data relating to 286 residential properties were collected in 2018. Findings The results show that the predictive accuracy of the developed neural network model is 78.95 per cent. Based on the sensitivity analysis of the model, it was revealed that balcony and floor area have the most significant impact on the rental price of residential properties. However, parking type and swimming pool had the least impact on rental price. Also, the availability of garden and proximity of police station had a low impact on rental price when compared to balcony. Practical implications In the light of these results, the developed neural network model could be used to estimate rental price for taxation. Also, the significant variables identified need to be included in the designs of new residential homes and this would ensure optimal returns to the investors. Originality/value A number of studies have shown that crime influences the value of residential properties. However, to the best of the authors’ knowledge, there is limited research investigating this relationship within the South African context.


2021 ◽  
Vol 13 (5) ◽  
pp. 969
Author(s):  
Ka Lok Chan ◽  
Ehsan Khorsandi ◽  
Song Liu ◽  
Frank Baier ◽  
Pieter Valks

In this paper, we present the estimation of surface NO2 concentrations over Germany using a machine learning approach. TROPOMI satellite observations of tropospheric NO2 vertical column densities (VCDs) and several meteorological parameters are used to train the neural network model for the prediction of surface NO2 concentrations. The neural network model is validated against ground-based in situ air quality monitoring network measurements and regional chemical transport model (CTM) simulations. Neural network estimation of surface NO2 concentrations show good agreement with in situ monitor data with Pearson correlation coefficient (R) of 0.80. The results also show that the machine learning approach is performing better than regional CTM simulations in predicting surface NO2 concentrations. We also performed a sensitivity analysis for each input parameter of the neural network model. The validated neural network model is then used to estimate surface NO2 concentrations over Germany from 2018 to 2020. Estimated surface NO2 concentrations are used to investigate the spatio-temporal characteristics, such as seasonal and weekly variations of NO2 in Germany. The estimated surface NO2 concentrations provide comprehensive information of NO2 spatial distribution which is very useful for exposure estimation. We estimated the annual average NO2 exposure for 2018, 2019 and 2020 is 15.53, 15.24 and 13.27 µµg/m3, respectively. While the annual average NO2 concentration of 2018, 2019 and 2020 is only 12.79, 12.60 and 11.15 µµg/m3. In addition, we used the surface NO2 data set to investigate the impacts of the coronavirus disease 2019 (COVID-19) pandemic on ambient NO2 levels in Germany. In general, 10–30% lower surface NO2 concentrations are observed in 2020 compared to 2018 and 2019, indicating the significant impacts of a series of restriction measures to reduce the spread of the virus.


Author(s):  
Duncan MacMichael ◽  
Dong Si

This article is driven by three goals. The first is to use machine learning to predict tree cover types, helping to address current challenges faced by U.S. forest management agencies. The second is to bring previous research in the area up-to-date, owing to a lack of development over time. The third is to improve on previous results with new data analysis, higher accuracy, and higher reliability. A Deep Neural Network (DNN) was constructed and compared with three baseline traditional machine learning models: Naïve Bayes, Decision Tree, and K-Nearest Neighbor (KNN). The neural network model achieved 91.55% accuracy while the best performing traditional classifier, K-Nearest Neighbor, managed 74.61%. In addition, the neural network model performed 20.97% better than the past neural networks, which illustrates both advances in machine learning algorithms, as well as improved accuracy high enough to apply practically to forest management issues. Using the techniques outlined in this article, agencies can cost-efficiently and quickly predict tree cover type and expedite natural resource inventorying.


2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Shipra Banik ◽  
A. F. M. Khodadad Khan ◽  
Mohammad Anwer

Forecasting stock market has been a difficult job for applied researchers owing to nature of facts which is very noisy and time varying. However, this hypothesis has been featured by several empirical experiential studies and a number of researchers have efficiently applied machine learning techniques to forecast stock market. This paper studied stock prediction for the use of investors. It is always true that investors typically obtain loss because of uncertain investment purposes and unsighted assets. This paper proposes a rough set model, a neural network model, and a hybrid neural network and rough set model to find optimal buy and sell of a share on Dhaka stock exchange. Investigational findings demonstrate that our proposed hybrid model has higher precision than the single rough set model and the neural network model. We believe this paper findings will help stock investors to decide about optimal buy and/or sell time on Dhaka stock exchange.


2020 ◽  
pp. 1141-1164
Author(s):  
Duncan MacMichael ◽  
Dong Si

This article is driven by three goals. The first is to use machine learning to predict tree cover types, helping to address current challenges faced by U.S. forest management agencies. The second is to bring previous research in the area up-to-date, owing to a lack of development over time. The third is to improve on previous results with new data analysis, higher accuracy, and higher reliability. A Deep Neural Network (DNN) was constructed and compared with three baseline traditional machine learning models: Naïve Bayes, Decision Tree, and K-Nearest Neighbor (KNN). The neural network model achieved 91.55% accuracy while the best performing traditional classifier, K-Nearest Neighbor, managed 74.61%. In addition, the neural network model performed 20.97% better than the past neural networks, which illustrates both advances in machine learning algorithms, as well as improved accuracy high enough to apply practically to forest management issues. Using the techniques outlined in this article, agencies can cost-efficiently and quickly predict tree cover type and expedite natural resource inventorying.


2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Ze Fu ◽  
Bo Zhang ◽  
Lingjun Ou ◽  
Kaiyang Sun ◽  
Xinyi Sun ◽  
...  

Compared with the past questionnaire survey, this paper applies the intelligent algorithm developed rapidly in recent years to identify the tendency of customers to buy financial products in the market. In addition, for the single state customer classification indicators based on the previous demographic information and action information, it is proposed to combine the action of market activities with demographic information; that is, the static integrated customer classification index is further combined with the improved neural network model to study the classification and preference of enterprise financial customers. Firstly, the enterprise financial customer classification model based on neural network algorithm is studied. Aiming at the shortcomings of easy falling into the local optimal solution of neural network algorithm, slow convergence speed of algorithm, and difficult setting of network structure, combined with the characteristics of genetic algorithm, the concept of adaptive genetic neural network algorithm is proposed. Then, the design of adaptive genetic neural network model is studied. Secondly, combined with the customer data of a financial enterprise and the characteristics of enterprise finance, this paper analyzes the risk influencing factors of enterprise financial customers, analyzes the customer data, evaluates the enterprise financial customers through the adaptive genetic neural network model, and realizes the classification of enterprise financial customers. Through an example, it is proved that the enterprise financial customer classification and preference model based on the adaptive genetic neural network algorithm discussed in this paper has better customer classification accuracy and can provide better method support for enterprise financial customer management.


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