scholarly journals Dynamics of Transmission and Control of COVID-19: A Real-time Estimation Using the Kalman Filter

Author(s):  
Francisco Arroyo Marioli ◽  
Francisco Bullano ◽  
Carlos Rondón-Moreno

AbstractThe COVID-19 pandemic has become the center of attention for both researchers and authorities. In this paper, we propose and test a methodology to estimate the daily effective reproduction number (ℛt) through the lens of the Kalman Filter and Bayesian estimation. Moreover, we apply our method to data from the current COVID-19 pandemic in China, Italy, Japan, and South Korea. We correlate our findings with the implementation of control measures in each of these countries. Our results show that China, Italy, and South Korea have been able to reduce ℛt over time. We find significant heterogeneity in the way ℛt decreases across countries. For instance, China reduced ℛt from its peak to below one in 19 days, while South Korea achieved the same reduction in 12 days. In contrast, it has taken Italy almost a month to reach similar levels. We hypothesize this is related to how strict, enforceable, and comprehensive are the implemented policies.

2018 ◽  
Vol 51 (15) ◽  
pp. 1062-1067 ◽  
Author(s):  
Mojtaba Sharifzadeh ◽  
Mario Pisaturo ◽  
Arash Farnam ◽  
Adolfo Senatore

2019 ◽  
Vol 147 ◽  
Author(s):  
Jessica Y. Wong ◽  
Edward Goldstein ◽  
Vicky J. Fang ◽  
Benjamin J. Cowling ◽  
Peng Wu

Abstract Statistical models are commonly employed in the estimation of influenza-associated excess mortality that, due to various reasons, is often underestimated by laboratory-confirmed influenza deaths reported by healthcare facilities. However, methodology for timely and reliable estimation of that impact remains limited because of the delay in mortality data reporting. We explored real-time estimation of influenza-associated excess mortality by types/subtypes in each year between 2012 and 2018 in Hong Kong using linear regression models fitted to historical mortality and influenza surveillance data. We could predict that during the winter of 2017/2018, there were ~634 (95% confidence interval (CI): (190, 1033)) influenza-associated excess all-cause deaths in Hong Kong in population ⩾18 years, compared to 259 reported laboratory-confirmed deaths. We estimated that influenza was associated with substantial excess deaths in older adults, suggesting the implementation of control measures, such as administration of antivirals and vaccination, in that age group. The approach that we developed appears to provide robust real-time estimates of the impact of influenza circulation and complement surveillance data on laboratory-confirmed deaths. These results improve our understanding of the impact of influenza epidemics and provide a practical approach for a timely estimation of the mortality burden of influenza circulation during an ongoing epidemic.


Author(s):  
Alberto Ferrari ◽  
Pieter Ginis ◽  
Michael Hardegger ◽  
Filippo Casamassima ◽  
Laura Rocchi ◽  
...  

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