scholarly journals Regulation of Iron Homeostasis Through Parkin-mediated Lactoferrin Ubiquitylation

2020 ◽  
Author(s):  
Ankur A. Gholkar ◽  
Stefan Schmollinger ◽  
Erick F. Velasquez ◽  
Yu-Chen Lo ◽  
Whitaker Cohn ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ubiquitin Ligase ◽  
Neurodegenerative Disorders ◽  
Iron Homeostasis ◽  
Binding Proteins ◽  
Somatic Mutations ◽  
Iron Binding ◽  
Ubiquitin Ligase Activity ◽  
Iron Binding Proteins

ABSTRACTSomatic mutations that perturb Parkin ubiquitin ligase activity and the misregulation of iron homeostasis have both been linked to Parkinson’s disease. Lactotransferrin is a member of the transferrin iron binding proteins that regulate iron homeostasis and increased levels of Lactotransferrin and its receptor have been observed in neurodegenerative disorders like Parkinson’s disease. Here, we report that Parkin binds to Lactotransferrin and ubiquitylates it to regulate iron homeostasis.

scholarly journals CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity

2002 ◽  
Vol 10 (1) ◽  
pp. 55-67 ◽  
Author(s):  
Yuzuru Imai ◽  
Mariko Soda ◽  
Shigetsugu Hatakeyama ◽  
Takumi Akagi ◽  
Tsutomu Hashikawa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ubiquitin Ligase ◽  
Ubiquitin Ligase Activity ◽  
Familial Parkinson’S Disease

scholarly journals Effect of RyhB Small RNA on Global Iron Use in Escherichia coli

2005 ◽  
Vol 187 (20) ◽  
pp. 6962-6971 ◽  
Author(s):  
Eric Massé ◽  
Carin K. Vanderpool ◽  
Susan Gottesman
Keyword(s):  
Small Rna ◽  
Noncoding Rna ◽  
Iron Homeostasis ◽  
Binding Proteins ◽  
Global Gene Expression ◽  
Iron Binding ◽  
Cluster Assembly ◽  
Intracellular Iron ◽  
Direct Target ◽  
Iron Binding Proteins

ABSTRACT RyhB is a noncoding RNA regulated by the Fur repressor. It has previously been shown to cause the rapid degradation of a number of mRNAs that encode proteins that utilize iron. Here we examine the effect of ectopic RyhB production on global gene expression by microarray analysis. Many of the previously identified targets were found, as well as other mRNAs encoding iron-binding proteins, bringing the total number of regulated operons to at least 18, encoding 56 genes. The two major operons involved in Fe-S cluster assembly showed different behavior; the isc operon appears to be a direct target of RyhB action, while the suf operon does not. This is consistent with previous findings suggesting that the suf genes but not the isc genes are important for Fe-S cluster synthesis under iron-limiting conditions, presumably for essential iron-binding proteins. In addition, we observed repression of Fur-regulated genes upon RyhB expression, interpreted as due to intracellular iron sparing resulting from reduced synthesis of iron-binding proteins. Our results demonstrate the broad effects of a single noncoding RNA on iron homeostasis.

scholarly journals Imaging Familial and Sporadic Neurodegenerative Disorders Associated with Parkinsonism

2021 ◽  
Author(s):  
David J. Brooks
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurodegenerative Disorders ◽  
Lewy Body Dementia ◽  
Imaging Biomarkers ◽  
Imaging Findings ◽  
Subclinical Disease ◽  
Similarities And Differences ◽  
Potential Use

AbstractIn this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed.

Ability ofVibrio vulnificus to obtain iron from transferrin and other iron-binding proteins

1987 ◽  
Vol 15 (3) ◽  
pp. 155-157 ◽  
Author(s):  
Linda M. Simpson ◽  
James D. Oliver
Keyword(s):  
Binding Proteins ◽  
Iron Binding ◽  
Iron Binding Proteins

scholarly journals Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

2010 ◽  
Vol 30 (7) ◽  
pp. 2454-2463 ◽  
Author(s):  
M. Gerard ◽  
A. Deleersnijder ◽  
V. Daniels ◽  
S. Schreurs ◽  
S. Munck ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Binding Proteins ◽  
Fk506 Binding Proteins
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