scholarly journals Multimodal FDG-PET and EEG assessment improves diagnosis and prognostication of disorders of consciousness

2020 ◽  
Author(s):  
Bertrand Hermann ◽  
Johan Stender ◽  
Marie-Odile Habert ◽  
Aurélie Kas ◽  
Mélanie Denis-Valente ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Fdg Pet ◽  
Imaging Techniques ◽  
Disorders Of Consciousness ◽  
Behavioral Patterns ◽  
Complementary Information ◽  
Multimodal Assessment ◽  
Metabolic Index

ABSTRACTThe complex diagnosis of disorders of consciousness (DoC) diagnosis increasingly relies on brain-imaging techniques for their ability to detect residual signs of consciousness in otherwise unresponsive patients. However, few of these techniques have been validated on external datasets. Here, we show that the FDG-PET glucose metabolic index of the best preserved hemisphere has robust in-sample and out-sample performances to diagnose DoC, slightly outperforming EEG-based classification. We further show that a multimodal assessment combining both FDG-PET and EEG not only improved diagnostic performances, but also allowed to identify covert cognition and to predict 6-month responsiveness in initially unresponsive patients. Lastly, we show that DoC heterogeneity reflects a sum of regional cortical metabolic differences, and their corresponding behavioral patterns, rather than a binary contrast between conscious and unconscious states. In total, we show that FDG-PET and EEG provide complementary information on DoC physiopathology and that their combination improves DoC diagnosis and prognostication.

The utility of FDG-PET/CT and other imaging techniques in the evaluation of IgG4-related disease

2014 ◽  
Vol 81 (4) ◽  
pp. 331-336 ◽  
Author(s):  
Hiroyuki Takahashi ◽  
Hiroyuki Yamashita ◽  
Miyako Morooka ◽  
Kazuo Kubota ◽  
Yuko Takahashi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Imaging Techniques ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals The accuracy of diagnostic Imaging techniques in patients with a suspected Fracture-related Infection (IFI) trial: study protocol for a prospective multicenter cohort study.

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e027772 ◽  
Author(s):  
GAM Govaert ◽  
MGG Hobbelink ◽  
IHF Reininga ◽  
P Bosch ◽  
TC Kwee ◽  
...  
Keyword(s):  
Cohort Study ◽  
The Netherlands ◽  
Diagnostic Imaging ◽  
Fdg Pet ◽  
Imaging Techniques ◽  
Time Frame ◽  
Imaging Modalities ◽  
Multicenter Cohort Study ◽  
Discriminative Ability ◽  
Imaging Strategy

IntroductionThe optimal diagnostic imaging strategy for fracture-related infection (FRI) remains to be established. In this prospective study, the three commonly used advanced imaging techniques for diagnosing FRI will be compared. Primary endpoints are (1) determining the overall diagnostic performances of white blood cell (WBC) scintigraphy, fluorodeoxyglucose positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) in patients with suspected FRI and (2) establishing the most accurate imaging strategy for diagnosing FRI.Methods and analysisThis study is a non-randomised, partially blinded, prospective cohort study involving two level 1 trauma centres in The Netherlands. All adult patients who require advanced medical imaging for suspected FRI are eligible for inclusion. Patients will undergo all three investigational imaging procedures (WBC scintigraphy, FDG-PET and MRI) within a time frame of 14 days after inclusion. The reference standard will be the result of at least five intraoperative sampled microbiology cultures, or, in case of no surgery, the clinical presence or absence of infection at 1 year follow-up. Initially, the results of all three imaging modalities will be available to the treating team as per local protocol. At a later time point, all scans will be centrally reassessed by nuclear medicine physicians and radiologists who are blinded for the identity of the patients and their clinical outcome. The discriminative ability of the imaging modalities will be quantified by several measures of diagnostic accuracy.Ethics and disseminationApproval of the study by the Institutional Review Board has been obtained prior to the start of this study. The results of this trial will be disseminated by publication of peer-reviewed manuscripts, presentation in abstract form at scientific meetings and data sharing with other investigators through academically established means.Trial registration numberThe IFI trial is registered in the Netherlands Trial Register (NTR7490).

[68Ga] Ga-DOTA-FAPI-04 And [18F] FDG PET / CT For Diagnosis of Metastatic Lesions In Patients With Recurrent Papillary Thyroid Carcinoma

2021 ◽  
Author(s):  
Umut Elboğa ◽  
Zeynel Abidin Sayiner ◽  
Ertan Şahin ◽  
Saadettin Öztürk ◽  
Yusuf Burak Çayırlı ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Fdg Pet ◽  
Imaging Techniques ◽  
Statistical Significance ◽  
Ct Imaging ◽  
Papillary Thyroid ◽  
Metastatic Focus ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Context: PET CT imaging methods based on fibroblast activation protein inhibitors (FAPIs) have recently demonstrated promising clinical results. Objective: We aimed to evaluate the use of 68Ga-FAPI PET / CT and 18FDG PET / CT imaging techniques to detect the metastatic foci in recurrent papillary thyroid carcinoma.Design and Patients: This is a prospective study. Patients who were diagnosed with papillary thyroid carcinoma, achieved biochemical recovery after the first operation and having recurrence for papillary thyroid carcinoma on the follow up were included in the study. [68Ga] Ga-DOTA-FAPI-04 and [18F] FDG PET / CT were performed for comparative purpose and detection of recurrence localization.Results: [18F] FDG PET / CT detected the metastatic foci in 21 of 29 patients (72.4%), [68Ga] Ga-DOTA-FAPI-04 was able to detect the metastatic foci in 25 of 29 patients (86.2%). When the two imaging techniques were used together, the metastatic foci in 27 of the 29 patients could be detected (93.1%.). Also between the [18F] FDG PET / CT SUVmax values and [68Ga] Ga-DOTA-FAPI-04 SUVmax values, a statistical significance was found in favor of 68Ga-FAPI PET (p = 0,002).Conclusion: In conclusion, 68Ga-FAPI PET imaging technique can be used as an alternative method to detect the metastatic focus or foci in patients with recurrent papillary thyroid carcinoma. It can also increase the chance of metastatic focus or foci detection when used in conjunction with the 18 FDG PET.

scholarly journals Nuclear Imaging in Infective Endocarditis

2021 ◽  
Vol 15 (1) ◽  
pp. 14
Author(s):  
Nidaa Mikail ◽  
Fabien Hyafil
Keyword(s):  
Computed Tomography ◽  
Infective Endocarditis ◽  
Fdg Pet ◽  
Imaging Techniques ◽  
Nuclear Imaging ◽  
Emission Tomography ◽  
Cardiac Devices ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Infective endocarditis (IE) is a life-threatening disease with stable prevalence despite prophylactic, diagnostic, and therapeutic advances. In parallel to the growing number of cardiac devices implanted, the number of patients developing IE on prosthetic valves and cardiac implanted electronic device (CIED) is increasing at a rapid pace. The diagnosis of IE is particularly challenging, and currently relies on the Duke-Li modified classification, which include clinical, microbiological, and imaging criteria. While echocardiography remains the first line imaging technique, especially in native valve endocarditis, the incremental value of two nuclear imaging techniques, 18F-fluorodeoxyglucose positron emission tomography with computed tomography (18F-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT), has emerged for the management of prosthetic valve and CIED IE. In this review, we will summarize the procedures for image acquisition, discuss the role of 18F-FDG-PET/CT and WBC-SPECT imaging in different clinical situations of IE, and review the respective diagnostic performance of these nuclear imaging techniques and their integration into the diagnostic algorithm for patients with a suspicion of IE.

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