scholarly journals Prevalence of amyloid blood clots in COVID-19 plasma

2020 ◽  
Author(s):  
Etheresia Pretorius ◽  
Chantelle Venter ◽  
Gert J Laubscher ◽  
Petrus J Lourens ◽  
Janami Steenkamp ◽  
...  
Keyword(s):  
Early Detection ◽  
Rapid Detection ◽  
Blood Clots ◽  
The Individual ◽  
Early Detection And Prevention ◽  
Native Plasma

The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.

scholarly journals Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma

2020 ◽  
Author(s):  
Etheresia Pretorius ◽  
Chantelle Venter ◽  
Gert Jacobus Laubscher ◽  
Petrus Johannes Lourens ◽  
Janami Steenkamp ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Early Detection ◽  
Rapid Detection ◽  
Blood Clots ◽  
The Individual ◽  
Early Detection And Prevention ◽  
Native Plasma

Abstract Background Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are a common accompaniment to both T2DM and COVID-19. In addition, patients with COVID-19 are known to develop micro-clots within the lungs. The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated clotting severity and the extent of clotting pathologies in the individual who was infected or not would be highly desirable. Methods We show here that microclots can be detected in the native plasma of COVID-19, as well as T2DM patients, without the addition of any clotting agent, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. Results In COVID-19 plasma these microclots are significantly increased when compared to the levels in T2DM. Conclusions This fluorogenic test may provide a rapid and convenient test with 100% sensitivity (P < 0.0001), and is consistent with the recognition that the early detection and prevention of such clotting can have an important role in therapy.

scholarly journals Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Etheresia Pretorius ◽  
Chantelle Venter ◽  
Gert Jacobus Laubscher ◽  
Petrus Johannes Lourens ◽  
Janami Steenkamp ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rapid Detection ◽  
Preliminary Report ◽  
Blood Clots ◽  
The Individual ◽  
Early Detection And Prevention ◽  
Native Plasma

Abstract Background Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are a common accompaniment to both T2DM and COVID-19. In addition, patients with COVID-19 are known to develop micro-clots within the lungs. The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated clotting severity and the extent of clotting pathologies in the individual who was infected or not would be highly desirable. Methods Platelet poor plasma (PPP) was collected and frozen. On the day of analysis, PPP samples were thawed and analysed. We show here that microclots can be detected in the native plasma of twenty COVID-19, as well as ten T2DM patients, without the addition of any clotting agent, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. Results were compared to ten healthy age-matched individuals. Results In COVID-19 plasma these microclots are significantly increased when compared to the levels in T2DM. Conclusions This fluorogenic test may provide a rapid and convenient test with 100% sensitivity (P < 0.0001) and is consistent with the recognition that the early detection and prevention of such clotting can have an important role in therapy.

scholarly journals Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: A preliminary report

2020 ◽  
Author(s):  
Etheresia Pretorius ◽  
Chantelle Venter ◽  
Gert Jacobus Laubscher ◽  
Petrus Johannes Lourens ◽  
Janami Steenkamp ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Rapid Detection ◽  
Preliminary Report ◽  
Blood Clots ◽  
The Individual ◽  
Early Detection And Prevention ◽  
Native Plasma

Abstract Background: Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are a common accompaniment to both T2DM and COVID-19. In addition, patients with COVID-19 are known to develop micro-clots within the lungs. The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated clotting severity and the extent of clotting pathologies in the individual who was infected or not would be highly desirable. Methods: Platelet poor plasma (PPP) was collected and frozen. On the day of analysis, PPP samples were thawed and analysed. We show here that microclots can be detected in the native plasma of twenty COVID-19, as well as ten T2DM patients, without the addition of any clotting agent, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. Results were compared to ten healthy age-matched individuals.Results: In COVID-19 plasma these microclots are significantly increased when compared to the levels in T2DM. Conclusions: This fluorogenic test may provide a rapid and convenient test with 100% sensitivity (P<0.0001) and is consistent with the recognition that the early detection and prevention of such clotting can have an important role in therapy.

Modern prevention and active longevity programs on the basis of disruptive domestic technologies: positive experience and prospects for application

2020 ◽  
pp. 66-73
Author(s):  
A. Simonova ◽  
S. Chudakov ◽  
R. Gorenkov ◽  
V. Egorov ◽  
A. Gostry ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Early Detection ◽  
Laboratory Diagnostics ◽  
Positive Experience ◽  
Practical Application ◽  
Wide Range ◽  
Integrated Program ◽  
Long Term Experience ◽  
Early Detection And Prevention

The article summarizes the long-term experience of practical application of domestic breakthrough technologies of preventive personalized medicine for laboratory diagnostics of a wide range of socially significant non-infectious diseases. Conceptual approaches to the formation of an integrated program for early detection and prevention of civilization diseases based on these technologies are given. A vision of the prospects for the development of this area in domestic and foreign medicine has been formed.

scholarly journals Emerging strategies for the early detection and prevention of head and neck squamous cell cancer

2011 ◽  
Vol 227 (2) ◽  
pp. 467-473 ◽  
Author(s):  
Santanu Dasgupta ◽  
Rupesh Dash ◽  
Swadesh K. Das ◽  
Devanand Sarkar ◽  
Paul B. Fisher
Keyword(s):  
Early Detection ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Early Detection And Prevention ◽  
Neck Squamous Cell Cancer

A Suite of Intelligent Tools for Early Detection and Prevention of Blackouts in Power Interconnections

2018 ◽  
Vol 79 (10) ◽  
pp. 1741-1755 ◽  
Author(s):  
N. I. Voropai ◽  
N. V. Tomin ◽  
D. N. Sidorov ◽  
V. G. Kurbatsky ◽  
D. A. Panasetsky ◽  
...  
Keyword(s):  
Early Detection ◽  
Intelligent Tools ◽  
Early Detection And Prevention

Early Detection and Prevention of Emotional or Behavioral Disorders: Developmental Aspects of Systems of Care

1996 ◽  
Vol 21 (3) ◽  
pp. 226-240 ◽  
Author(s):  
Steven R. Forness ◽  
Kenneth A. Kavale ◽  
Donald L. Macmillan ◽  
Joan R. Asarnow ◽  
Brent B. Duncan
Keyword(s):  
Early Detection ◽  
Behavioral Disorders ◽  
Systems Of Care ◽  
Primary And Secondary Prevention ◽  
Early Screening ◽  
Ongoing Assessment ◽  
Current Systems ◽  
Interdisciplinary Network ◽  
Early Detection And Prevention ◽  
Emotional Or Behavioral Disorders

Although current systems of care for children with emotional or behavioral disorders generally focus on wrap-around services in an interagency or interdisciplinary network, it is not clear that potential for early detection and prevention is fully realized. Problems in early identification in current systems are discussed along with current methods for early screening. Use of early detection and ongoing assessment of response as a basis for more focused intervention is described. Primary and secondary prevention issues also are discussed in relation to this approach.

Early detection and prevention of vision defects

2018 ◽  
pp. 77-95
Author(s):  
Micha de Winter ◽  
Mariëlle Balledux ◽  
José de Mare ◽  
Ruud Burgmeijer
Keyword(s):  
Early Detection ◽  
Vision Defects ◽  
Early Detection And Prevention
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