scholarly journals The Influence of Pre-Supplementary Motor Area Targeted High-Definition Transcranial Direct Current Stimulation on Inhibitory Control

2020 ◽  
Author(s):  
Bambi L. DeLaRosa ◽  
Jeffrey S. Spence ◽  
Michael A. Motes ◽  
Wing To ◽  
Sven Vanneste ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Supplementary Motor Area ◽  
Event Related Potentials ◽  
Motor Area ◽  
High Definition ◽  
Direct Current Stimulation ◽  
Related Potentials ◽  
Cathodal Stimulation

AbstractThe neural underpinnings of inhibitory control, an executive cognitive control function, has been a topic of interest for several decades due to both its clinical significance and the maturation of cognitive science disciplines. Behavioral, imaging, and electrophysiological studies suggest that the pre-supplementary motor area (preSMA) serves as a primary hub in a network of regions engaged in inhibition. High-definition transcranial direct current stimulation (HD-tDCS) allows us to modulate neural function to assess cortical contribution to cognitive functioning. The present study targeted HD-tDCS modulation of preSMA to affect inhibition. Participants were randomly assigned to receive 20 min of Sham, Anodal, or Cathodal stimulation prior to completing a semantically cued go/nogo task while electroencephalography (EEG) data were recorded. Both anodal and cathodal stimulation improved inhibitory performance as measured by faster reaction times and increased (greater negative) N2 event-related potentials (ERPs). In contrast, the Sham group did not show such changes. We did not find support for the anodal/cathodal dichotomy for HD neural stimulation. These findings constitute an early investigation into role of the preSMA in inhibitory control and in exploring application of HD-tDCS to the preSMA in order to improve inhibitory control.

scholarly journals Case Report: Improving Verbal Retrieval Deficits With High Definition Transcranial Direct Current Stimulation Targeting the Pre-Supplementary Motor Area in a Patient With Chronic Traumatic Brain Injury

2021 ◽  
Vol 12 ◽  
Author(s):  
Hsueh-Sheng Chiang ◽  
Scott Shakal ◽  
Sven Vanneste ◽  
Michael Kraut ◽  
John Hart
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Supplementary Motor Area ◽  
Event Related Potentials ◽  
Motor Area ◽  
High Definition ◽  
Direct Current Stimulation ◽  
Related Potentials

We report a patient who has cognitive sequalae including verbal retrieval deficits after severe traumatic brain injury (TBI). The cortico-caudate-thalamic circuit involving the pre-Supplementary Motor Area (pre-SMA) has been proposed to underlie verbal retrieval functions. We hypothesized that High Definition-transcranial Direct Current Stimulation (HD-tDCS) targeting the pre-SMA would selectively modulate this circuit to remediate verbal retrieval deficits. After the patient underwent 10 sessions of 20 min of 1 mA HD-tDCS targeting the pre-SMA, we documented significant improvements for verbal fluency and naming, and for working memory and executive function tasks that involve the frontal lobes. The effects persisted for up to 14 weeks after completion of HD-tDCS treatment. We also demonstrated normalization of the event-related potentials suggesting modulation of the underlying neural circuit. Our study implicates that region-specific non-invasive brain stimulation, such as HD-tDCS, serves as a potential individualized therapeutic tool to treat cognitive deficits by inducing longer-lasting neuroplasticity even in the chronic phase of TBI.

scholarly journals Effect of Cathodal Transcranial Direct Current Stimulation on a Child with Involuntary Movement after Hypoxic Encephalopathy

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Mayumi Nagai ◽  
Naofumi Tanaka ◽  
Yutaka Oouchida ◽  
Shin-Ichi Izumi
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Supplementary Motor Area ◽  
Involuntary Movement ◽  
Motor Area ◽  
Involuntary Movements ◽  
Hypoxic Encephalopathy ◽  
Direct Current Stimulation ◽  
Cathodal Stimulation ◽  
Motor Areas

The aim of the study was to investigate the effect of cathodal transcranial direct current stimulation to the supplementary motor area to inhibit involuntary movements of a child. An 8-year-old boy who developed hypoxic encephalopathy after asphyxia at the age of 2 had difficulty in remaining standing without support because of involuntary movements. He was instructed to remain standing with his plastic ankle-foot orthosis for 10 s at three time points by leaning forward with his forearms on a desk. He received cathodal or sham transcranial direct current stimulation to the supplementary motor area at 1 mA for 10 min. Involuntary movements during standing were measured using an accelerometer attached to his forehead. The low-frequency power of involuntary movements during cathodal transcranial direct current stimulation significantly decreased compared with that during sham stimulation. No adverse effects were observed. Involuntary movement reduction by cathodal stimulation to supplementary motor areas suggests that stimulations modulated the corticobasal ganglia motor circuit. Cathodal stimulation to supplementary motor areas may be effective for reducing involuntary movements and may be safely applied to children with movement disorders.

Modulating Effects of Transcranial Direct Current Stimulation on Event Related Potentials in a Motor Sequence Task

2014 ◽  
Vol 7 (2) ◽  
pp. e7
Author(s):  
Stephanie Rohrig ◽  
Devin Adair ◽  
Aleksandra Kaszowska ◽  
Pejman Sehatpour ◽  
Daniel C. Javitt
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Event Related Potentials ◽  
Motor Sequence ◽  
Direct Current Stimulation ◽  
Related Potentials

Transcranial Direct Current Stimulation of Pre-Supplementary Motor Area for SSRI resistant OCD

2015 ◽  
Vol 8 (2) ◽  
pp. 372
Author(s):  
Janardhanan C. Narayanaswamy ◽  
Dania Jose ◽  
Harleen Chabra ◽  
Sri Mahavir Agarwal ◽  
Basavaraj Shrinivasa ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Supplementary Motor Area ◽  
Motor Area ◽  
Direct Current Stimulation ◽  
Stimulation Of

Transcranial Direct Current Stimulation Combined With Cognitive Training Induces Response Inhibition Facilitation Through Distinct Neural Responses According to the Stimulation Site: A Follow-up Event-Related Potentials Study

2020 ◽  
pp. 155005942095896
Author(s):  
Clémence Dousset ◽  
Anaïs Ingels ◽  
Elisa Schröder ◽  
Laura Angioletti ◽  
Michela Balconi ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cognitive Rehabilitation ◽  
Response Times ◽  
Inferior Frontal Gyrus ◽  
Training Session ◽  
Event Related Potentials ◽  
Stimulation Site ◽  
Direct Current Stimulation ◽  
Related Potentials

Objective We investigated whether the mid-term impact (1 week posttraining) of a “combined cognitive rehabilitation (CRP)/transcranial direct current stimulation (tDCS) program” on the performance of a Go/No-go task was enhanced compared with isolated CRP and whether it varied according to the stimulation site (right inferior frontal gyrus [rIFG] vs right dorsolateral prefrontal cortex [rDLPFC]). Methods A total of 150 healthy participants were assigned to (1) an Inhibition Training (IT) group, (2) a group receiving active tDCS over the rIFG in combination with IT (IT + IF), (3) a group receiving active tDCS over the rDLPFC in combination with IT (IT + DL), (4) a group receiving IT with sham tDCS (ITsham), and (5) a No-Training (NT) group to control for test-retest effects. Each group undertook 3 sessions of a Go/No-go task concomitant with the recording of event-related potentials (T0, before training; T1, at the end of a 4-day training session [20 minutes each day]; T2, 1 week after T1). Results With the exception of the NT participants, all the groups exhibited improved performances at T2. The IT + DL group exhibited the best improvement profile, indexed by faster response times (RTs) (T0 > T1 = T2), with a reduced rate of errors at the posttraining sessions compared with both T0 and T1. This “inhibitory learning effect” was neurophysiologically indexed by shorter No-go N2d latencies and enhanced No-go P3d amplitudes. Conclusion CRP combined with active tDCS over the rDLPFC appears to be optimal for boosting long-term (one week) inhibitory skills as it induced specific and robust neural changes.

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