Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes

AbstractTraumatic brain injury (TBI) and drug addiction are common comorbidities, but it is unknown if the neurological sequelae of TBI contribute to this relationship. We have previously reported elevated oxycodone seeking after drug self-administration in rats that received repeated blast TBI (rbTBI). TBI and exposure to drugs of abuse can each change structural and functional neuroimaging outcomes, but it is unknown if there are interactive effects of injury and drug exposure. To determine the effects of TBI and oxycodone exposure, we subjected rats to rbTBI and oxycodone self-administration and measured drug seeking and several neuroimaging measures. We found interactive effects of rbTBI and oxycodone on fractional anisotropy (FA) in the nucleus accumbens (NAc), and that FA in the medial prefrontal cortex (mPFC) was correlated with drug seeking. We also found an interactive effect of injury and drug on widespread functional connectivity and regional homogeneity of the BOLD response, and that interhemispheric functional connectivity in the infralimbic medial prefrontal cortex positively correlated with drug seeking. In conclusion, rbTBI and oxycodone self-administration had interactive effects on structural and functional MRI measures, and correlational effects were found between some of these measures and drug seeking. These data support the hypothesis that TBI and opioid exposure produce neuroadaptations that contribute to addiction liability.

Download Full-text

A Selective Depolarisation-Induced Increase in Excitatory Amino Acid Neurotransmitter Release in Rat Medial Prefrontal Cortex Using a Microdialysis Model of Traumatic Brain Injury

IUTAM Symposium on Impact Biomechanics: From Fundamental Insights to Applications - Solid Mechanics and Its Applications ◽

10.1007/1-4020-3796-1_41 ◽

2005 ◽

pp. 393-404 ◽

Cited By ~ 1

Author(s):

Aoife Smyth ◽

Michael D. Gilchrist ◽

William T. O'Connor

Keyword(s):

Traumatic Brain Injury ◽

Prefrontal Cortex ◽

Amino Acid ◽

Brain Injury ◽

Medial Prefrontal Cortex ◽

Neurotransmitter Release ◽

Excitatory Amino Acid

Download Full-text

Repeated blast model of mild traumatic brain injury alters oxycodone self‐administration and drug seeking

European Journal of Neuroscience ◽

10.1111/ejn.14281 ◽

2018 ◽

Vol 50 (3) ◽

pp. 2101-2112 ◽

Cited By ~ 6

Author(s):

Natalie N. Nawarawong ◽

Megan Slaker ◽

Matt Muelbl ◽

Alok S. Shah ◽

Rachel Chiariello ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Self Administration ◽

Drug Seeking

Download Full-text

Aggression, DRD1 polymorphism, and lesion location in penetrating traumatic brain injury

CNS Spectrums ◽

10.1017/s1092852914000108 ◽

2014 ◽

Vol 19 (5) ◽

pp. 382-390 ◽

Cited By ~ 8

Author(s):

Matteo Pardini ◽

Frank Krueger ◽

Colin A. Hodgkinson ◽

Vanessa Raymont ◽

Maren Strenziok ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Prefrontal Cortex ◽

Brain Injury ◽

Dopamine Receptor ◽

Medial Prefrontal Cortex ◽

Dopaminergic System ◽

Lateral Prefrontal Cortex ◽

Lesion Location ◽

Comt Val158met ◽

The Relationship

ObjectiveThis study evaluated whether structural brain lesions modulate the relationship between pathological aggression and the dopaminergic system in traumatic brain injury (TBI). While converging evidence suggests that different areas of the prefrontal cortex modulate dopaminergic activity, to date no evidence exists of a modulation of endogenous dopaminergic tone by lesion localization in penetrating TBI (pTBI).MethodsThis study included 141 male Caucasian veterans who suffered penetrating pTBI during their service in Vietnam and 29 healthy male Caucasian Vietnam veterans. Participants were genotyped for 3 functional single nucleotide polymorphisms (SNPs): dopamine receptor D1 (DRD1) rs686, dopamine receptor D2 (DRD2) rs4648317, and catechol-O-methyltransferase (COMT) Val158Met. Patients underwent brain CT scans and were divided into medial prefrontal cortex, lateral prefrontal cortex, and posterior cortex lesion groups. Long-term aggression levels were evaluated with the agitation/aggression subscale of the Neuropsychiatric Inventory.ResultsOur data showed that carriers of more transcriptionally active DRD1 alleles compared to noncarriers demonstrated greater aggression levels due to medial prefrontal cortex lesions but reduced aggression levels due to lateral prefrontal cortex lesions independently of DRD2 rs4648317 or COMT Val158Met genotypes.ConclusionsOur results suggest that the relationship between pTBI-related aggression and the dopaminergic system is modulated by lesion location. Potentially lesion location could represent an easy-to-use, widely available, para-clinical marker to help in the development of an individualized therapeutic approach to pTBI-related pathological aggression.

Download Full-text

Mild Traumatic Brain Injury Reduces Spine Density of Projection Neurons in the Medial Prefrontal Cortex and Impairs Extinction of Contextual Fear Memory

Journal of Neurotrauma ◽

10.1089/neu.2016.4898 ◽

2018 ◽

Vol 35 (1) ◽

pp. 149-156 ◽

Cited By ~ 7

Author(s):

Jing Zhao ◽

Jonathan Huynh ◽

Michael J. Hylin ◽

John J. O'Malley ◽

Alec Perez ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Prefrontal Cortex ◽

Brain Injury ◽

Medial Prefrontal Cortex ◽

Mild Traumatic Brain Injury ◽

Fear Memory ◽

Projection Neurons ◽

Spine Density ◽

Contextual Fear ◽

Contextual Fear Memory

Download Full-text

Detecting functional connectivity disruptions in a translational pediatric traumatic brain injury porcine model using resting-state and task-based fMRI

Scientific Reports ◽

10.1038/s41598-021-91853-5 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Gregory Simchick ◽

Kelly M. Scheulin ◽

Wenwu Sun ◽

Sydney E. Sneed ◽

Madison M. Fagan ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Functional Connectivity ◽

Resting State ◽

Correlation Coefficients ◽

Brain Network ◽

Network Activity ◽

Anatomical Structures ◽

Healthy Control ◽

And Task

AbstractFunctional magnetic resonance imaging (fMRI) has significant potential to evaluate changes in brain network activity after traumatic brain injury (TBI) and enable early prognosis of potential functional (e.g., motor, cognitive, behavior) deficits. In this study, resting-state and task-based fMRI (rs- and tb-fMRI) were utilized to examine network changes in a pediatric porcine TBI model that has increased predictive potential in the development of novel therapies. rs- and tb-fMRI were performed one day post-TBI in piglets. Activation maps were generated using group independent component analysis (ICA) and sparse dictionary learning (sDL). Activation maps were compared to pig reference functional connectivity atlases and evaluated using Pearson spatial correlation coefficients and mean ratios. Nonparametric permutation analyses were used to determine significantly different activation areas between the TBI and healthy control groups. Significantly lower Pearson values and mean ratios were observed in the visual, executive control, and sensorimotor networks for TBI piglets compared to controls. Significant differences were also observed within several specific individual anatomical structures within each network. In conclusion, both rs- and tb-fMRI demonstrate the ability to detect functional connectivity disruptions in a translational TBI piglet model, and these disruptions can be traced to specific affected anatomical structures.

Download Full-text

1171 SHORT-WAVELENGTH LIGHT THERAPY AS A WAY OF IMPROVING SLEEP, COGNITION, AND FUNCTIONAL CONNECTIVITY FOLLOWING A MILD TRAUMATIC BRAIN INJURY

SLEEP ◽

10.1093/sleepj/zsx050.1170 ◽

2017 ◽

Vol 40 (suppl_1) ◽

pp. A437-A437

Author(s):

JR Vanuk ◽

BR Shane ◽

S Bajaj ◽

M Millan ◽

M Grandner ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Functional Connectivity ◽

Mild Traumatic Brain Injury ◽

Short Wavelength ◽

Light Therapy ◽

Short Wavelength Light ◽

Wavelength Light

Download Full-text

Traumatic Brain Injury as a Disorder of Brain Connectivity

Journal of the International Neuropsychological Society ◽

10.1017/s1355617715000740 ◽

2016 ◽

Vol 22 (2) ◽

pp. 120-137 ◽

Cited By ~ 83

Author(s):

Jasmeet P. Hayes ◽

Erin D. Bigler ◽

Mieke Verfaellie

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

White Matter ◽

Functional Connectivity ◽

Negative Impact ◽

Axonal Injury ◽

Resting State Functional Connectivity ◽

Post Injury ◽

Recent Advances

AbstractObjectives:Recent advances in neuroimaging methodologies sensitive to axonal injury have made it possible to assess in vivo the extent of traumatic brain injury (TBI) -related disruption in neural structures and their connections. The objective of this paper is to review studies examining connectivity in TBI with an emphasis on structural and functional MRI methods that have proven to be valuable in uncovering neural abnormalities associated with this condition.Methods:We review studies that have examined white matter integrity in TBI of varying etiology and levels of severity, and consider how findings at different times post-injury may inform underlying mechanisms of post-injury progression and recovery. Moreover, in light of recent advances in neuroimaging methods to study the functional connectivity among brain regions that form integrated networks, we review TBI studies that use resting-state functional connectivity MRI methodology to examine neural networks disrupted by putative axonal injury.Results:The findings suggest that TBI is associated with altered structural and functional connectivity, characterized by decreased integrity of white matter pathways and imbalance and inefficiency of functional networks. These structural and functional alterations are often associated with neurocognitive dysfunction and poor functional outcomes.Conclusions:TBI has a negative impact on distributed brain networks that lead to behavioral disturbance. (JINS, 2016,22, 120–137)

Download Full-text