scholarly journals Quantitative susceptibility mapping of carotid arterial tissue ex vivo: assessing sensitivity to vessel microstructural composition

2021 ◽  
Author(s):  
Alan J. Stone ◽  
Brooke Tornifoglio ◽  
Robert D. Johnston ◽  
Karin Shmueli ◽  
Christian Kerskens ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Carotid Arteries ◽  
Ex Vivo ◽  
Enzymatic Digestion ◽  
Susceptibility Mapping ◽  
Specific Marker ◽  
Quantitative Susceptibility Mapping ◽  
Healthy Human ◽  
Significant Difference ◽  
Arterial Tissue

AbstractPurposeTo characterise microstructural contributions to the magnetic susceptibility of carotid arteries.MethodArterial vessels were scanned using high resolution quantitative susceptibility mapping (QSM) at 7T. Models of vessel degradation were generated using ex vivo porcine carotid arteries that were subjected to several different enzymatic digestion treatments that selectively removed microstructural components (smooth muscle cells, collagen and elastin). Magnetic susceptibilities measured in these tissue models were compared to those in untreated (native) porcine arteries. Magnetic susceptibility measured in native porcine carotid arteries was further compared to the susceptibility of cadaveric human carotid arteries to investigate their similarity.ResultsThe magnetic susceptibility of native porcine vessels was diamagnetic (𝒳native = −0.1820ppm), with higher susceptibilities in all models of vessel degradation (𝒳elastin degraded = −0.0163ppm; 𝒳collagen degraded = −0.1158ppm; 𝒳decellularised = −0.1379ppm; 𝒳fixed native = −0.2199ppm). Magnetic susceptibility was significantly higher in collagen degraded compared to native porcine vessels (Tukey-Kramer, p<0.01) and between elastin degraded and all other models (including native, Tukey-Kramer, p<0.001). The susceptibility of fixed healthy human arterial tissue was diamagnetic and no significant difference was found between fixed human and fixed porcine arterial tissue susceptibilities (ANOVA, p>0.05).ConclusionsMagnetic susceptibility measured using QSM is sensitive to the microstructural composition of arterial vessels – most notably to collagen. The similarity of human and porcine arterial tissue susceptibility values provides a solid basis for translational studies. As vessel microstructure becomes disrupted during the onset and progression of carotid atherosclerosis, QSM has the potential to provide a sensitive and specific marker of vessel disease.

IC-P-145: EX-VIVO QUANTITATIVE SUSCEPTIBILITY MAPPING (QSM) IN A COMMUNITY COHORT REVEALS LINK BETWEEN MAGNETIC SUSCEPTIBILITY AND ALZHEIMER'S PATHOLOGY

2014 ◽  
Vol 10 ◽  
pp. P83-P84
Author(s):  
Arnold Moya Evia ◽  
Konstantinos Arfanakis ◽  
David Bennett ◽  
Julie Schneider ◽  
Aikaterini Kotrotsou ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Alzheimer’S Pathology

Investigating Optimal Echo Times for Quantitative Susceptibility Mapping of Basal Ganglia Nuclei in the Healthy Brain

2020 ◽  
Vol 16 (8) ◽  
pp. 991-996
Author(s):  
Wenping Fan ◽  
Xue Wang ◽  
Xingwen Zhang ◽  
Mengqi Liu ◽  
Qinglin Meng ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Clinical Practice ◽  
Standard Deviation ◽  
Basal Ganglia ◽  
Caudate Nucleus ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Significant Difference ◽  
The Mean ◽  
Echo Time

Background: Quantitative susceptibility mapping (QSM) technique had been used to measure the magnetic susceptibility of brain tissue in clinical practice. However, QSM presented echo-time (TE) dependence, and an appropriate number of echo-times (nTEs) for QSM became more important to obtain the reliable susceptibility value. Objective: The aim of the study was to explore the optimal nTEs for quantitative susceptibility mapping (QSM) measurements of basal ganglia nuclei in the healthy brain. Methods: 3D multi-echo enhanced gradient recalled echo T2 star weighted angiography (ESWAN) sequence was acquired on a 3.0T MR scanner for QSM analysis. Regions of interests (ROIs) were drawn along the margin of the head of the caudate nucleus (HCN), putamen (Pu) and globus pallidus (GP). The mean susceptibility value and standard deviation of the ROIs were derived from the pixels within each region. Results: CV analysis demonstrated that TE6, TE8 and TE14 ESWAN sequences presented consistent lower CV value (<1) for QSM measure of HCN, Pu and GP. ANOVA identified that susceptibility value showed no significant difference between TE6 and TE8 in HCN, Pu and GP (P > 0.05). ICC analysis demonstrated that the susceptibility value of TE6-TE8 had the highest ICC value as compared with TE6-TE14 and TE8-TE14 in HCN, Pu and GP. Combined with the timeefficiency of MRI scanning, TE6 sequence could not only provide the reliable QSM measurement but also short imaging time. Conclusions: The current study identified that the optimal nTEs of ESWAN were 6 TEs (2.9ms ~ 80.9ms) for QSM measurement of basal ganglia nuclei in the healthy brain.

EX VIVO QUANTITATIVE SUSCEPTIBILITY MAPPING (QSM) IN A COMMUNITY COHORT REVEALS LINK BETWEEN MAGNETIC SUSCEPTIBILITY AND ALZHEIMER'S PATHOLOGY

2014 ◽  
Vol 10 ◽  
pp. P549-P550
Author(s):  
Arnold Moya Evia ◽  
Konstantinos Arfanakis ◽  
David Bennett ◽  
Julie Schneider ◽  
Aikaterini Kotrotsou ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Alzheimer’S Pathology

scholarly journals Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments

2018 ◽  
Vol 80 (6) ◽  
pp. 2702-2716 ◽  
Author(s):  
Olli Nykänen ◽  
Lassi Rieppo ◽  
Juha Töyräs ◽  
Ville Kolehmainen ◽  
Simo Saarakkala ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

Effect of respiratory hyperoxic challenge on magnetic susceptibility in human brain assessed by quantitative susceptibility mapping (QSM)

2015 ◽  
Vol 28 (12) ◽  
pp. 1688-1696 ◽  
Author(s):  
Pinar Senay Özbay ◽  
Cristina Rossi ◽  
Roman Kocian ◽  
Manuel Redle ◽  
Andreas Boss ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Human Brain ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

scholarly journals Quantitative susceptibility mapping improves the detection of calcified carotid vessels by multi-contrast MRI using computed tomography angiography as the reference standard

2021 ◽  
Author(s):  
Thanh D Nguyen ◽  
Yan Wen ◽  
Jingwen Du ◽  
Pascal Spincemaille ◽  
Yi Wang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Carotid Artery ◽  
Vessel Wall ◽  
Carotid Arteries ◽  
Susceptibility Mapping ◽  
Reference Standard ◽  
Quantitative Susceptibility Mapping ◽  
Vessel Detection ◽  
Carotid Vessel Wall ◽  
Carotid Vessels

The objective of this study was to evaluate initial feasibility and improvement in the detection of calcified carotid arteries by including quantitative susceptibility mapping (QSM) in the carotid vessel wall multi-contrast MRI (mcMRI) protocol using CTA as the reference standard. In a pilot cohort of ten patients with significant carotid artery stenosis, calcified vessel detection by mcMRI achieved 64.7% sensitivity and 100% specificity. Adding QSM to mcMRI improved sensitivity to 100% while not affecting specificity.

Quantitative susceptibility mapping in spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD)

2019 ◽  
Vol 61 (4) ◽  
pp. 520-527
Author(s):  
Fangfang Xie ◽  
Liao Weihua ◽  
Ouyang Lirong ◽  
Xiaoyi Wang ◽  
Wu Xing
Keyword(s):  
Substantia Nigra ◽  
Globus Pallidus ◽  
Spinocerebellar Ataxia ◽  
Susceptibility Mapping ◽  
Iron Deposition ◽  
Spinocerebellar Ataxia Type ◽  
Quantitative Susceptibility Mapping ◽  
Significant Difference ◽  
Machado Joseph Disease ◽  
Normal Controls

Background The deep nuclei, brainstem, and anterior central gyrus are important sites of spinocerebellar ataxia type3/Machado–Joseph Disease (SCA3/MJD) involvement. These locations were the common iron deposition areas. We hypothesized that iron deposition changes occur in SCA3/MJD patients and are associated with disease progression. Purpose Quantitative susceptibility mapping was used to quantitatively analyze changes in iron levels in SCA3/MJD patients. Material and Methods Eighteen symptomatic SCA3/MJD patients and 18 age-matched normal controls (group 1; NC1), and 12 asymptomatic mutation carriers (pre-SCA3/MJD) and 16 age-matched normal controls (group 2; NC2) were examined by enhanced gradient echo T2*-weighted angiography. Data were processed to obtain the quantitative susceptibility mapping values. Independent sample t-tests were conducted to compare the differences in the quantitative susceptibility mapping values. Results In the red nuclei and substantia nigra, the quantitative susceptibility mapping values of the symptomatic SCA3/MJD group were significantly higher than those of NC1 ( P < 0.05). The quantitative susceptibility mapping values of the symptomatic SCA3/MJD group were higher than those of NC1 in the globus pallidus, but it was not statistically significant ( P = 0.056). No significant difference in quantitative susceptibility mapping values was found between the pre-SCA3/MJD and NC2. No significant correlation was found between the International Cooperative Ataxia Rating Scale and the Scale for the Assessment and Rating of Ataxia and the quantitative susceptibility mapping values. Conclusion The results clearly demonstrated the quantitative susceptibility mapping value increase in the globus pallidus, red nuclei, and substantia nigra of the symptomatic SCA3/MJD group, indicating iron overload in these nuclei, suggesting that iron deposition is associated with disease onset.

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