scholarly journals The mouse papillomavirus epigenetic signature is characterised by DNA hypermethylation after lesion regression

2021 ◽  
Author(s):  
Allison M. Tschirley ◽  
Peter A. Stockwell ◽  
Euan J. Rodger ◽  
Oliver Eltherington ◽  
Ian M. Morison ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Viral Infection ◽  
Cell Carcinoma ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Human Papillomaviruses ◽  
Dna Hypermethylation ◽  
Active Lesion ◽  
Lesion Regression ◽  
Increased Susceptibility

The β genus of human papillomaviruses (HPVs) infect cutaneous epidermis. They contribute to the development of cutaneous squamous cell carcinoma (cSCC) in individuals with epidermodysplasia verruciformis, and increase susceptibility to UV-induced cSCC. This has been demonstrated in UV-exposed mice previously infected with mouse papillomavirus (MmuPV1). However, the mechanism by which β-HPVs contribute to cSCC is unclear. We propose that viral infection leaves a DNA methylation signature following resolution of the active lesion that may contribute to increased susceptibility to UV-induced cSCC.

scholarly journals An Emerging Issue in Oncogenic Virology: the Role of Beta Human Papillomavirus Types in the Development of Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 93 (7) ◽  
Author(s):  
Dana E. Rollison ◽  
Daniele Viarisio ◽  
Rossybelle P. Amorrortu ◽  
Tarik Gheit ◽  
Massimo Tommasino
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Human Papillomaviruses ◽  
Skin Cancer Prevention ◽  
Malignant Phenotype ◽  
Dna Mutations ◽  
High Risk Populations

ABSTRACT Evidence suggests that beta human papillomaviruses (HPVs), together with ultraviolet radiation, contribute to the development of cutaneous squamous cell carcinoma. Beta HPVs appear to be not the main drivers of carcinogenesis but rather facilitators of the accumulation of ultraviolet-induced DNA mutations. Beta HPVs are promoters of skin carcinogenesis, although they are dispensable for the maintenance of the malignant phenotype. Therefore, beta HPV represents a target for skin cancer prevention, especially in high-risk populations.

scholarly journals An Evolutionary Cancer Epigenetic Approach Revealed DNA Hypermethylation of Ultra-Conserved Non-Coding Elements in Squamous Cell Carcinoma of Different Mammalian Species

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 2092
Author(s):  
Luca Morandi ◽  
Silvia Sabattini ◽  
Andrea Renzi ◽  
Antonella Rigillo ◽  
Giuliano Bettini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mammalian Species ◽  
Normal Mucosa ◽  
Dna Hypermethylation ◽  
Mammal Species ◽  
Healthy Human ◽  
Normal Controls

Background: Ultra-conserved non-coding elements (UCNEs) are genomic sequences that exhibit > 95% sequence identity between humans, mammals, birds, reptiles, and fish. Recent findings reported their functional role in cancer. The aim of this study was to evaluate the DNA methylation modifications of UNCEs in squamous cell carcinoma (SCC) from different mammal species. Methods: Fifty SCCs from 26 humans, 17 cats, 3 dogs, 1 horse, 1 bovine, 1 badger, and 1 porcupine were investigated. Fourteen feline stomatitis and normal samples from 36 healthy human donors, 7 cats, 5 dogs, 5 horses, 2 bovines and 1 badger were collected as normal controls. Bisulfite next generation sequencing evaluated the DNA methylation level from seven UCNEs (uc.160, uc.283, uc.416, uc.339, uc.270, uc.299, and uc.328). Results: 57/59 CpGs were significantly different according to the Kruskal–Wallis test (p < 0.05) comparing normal samples with SCC. A common DNA hypermethylation pattern was observed in SCCs from all the species evaluated in this study, with an increasing trend of hypermethylation starting from normal mucosa, through stomatitis to SCC. Conclusions: Our findings indicate that UCNEs are hypermethylated in human SCC, and this behavior is also conserved among different species of mammals.

scholarly journals Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0223341
Author(s):  
David Hervás-Marín ◽  
Faatiemah Higgins ◽  
Onofre Sanmartín ◽  
Jose Antonio López-Guerrero ◽  
M. Carmen Bañó ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Genome Wide ◽  
Dna Methylation Profiling ◽  
Methylation Profiling

scholarly journals Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

EBioMedicine ◽  
2021 ◽  
Vol 67 ◽  
pp. 103383
Author(s):  
Kevin Roth ◽  
Louis Coussement ◽  
Elena V. Knatko ◽  
Maureen Higgins ◽  
Sandra Steyaert ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Murine Model ◽  
Cutaneous Squamous Cell Carcinoma

scholarly journals Case-control study of genus-beta human papillomaviruses in plucked eyebrow hairs and cutaneous squamous cell carcinoma

2013 ◽  
Vol 134 (9) ◽  
pp. 2231-2244 ◽  
Author(s):  
Michelle R. Iannacone ◽  
Tarik Gheit ◽  
Herbert Pfister ◽  
Anna R. Giuliano ◽  
Jane L. Messina ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Human Papillomaviruses ◽  
Control Study

scholarly journals Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma

2019 ◽  
Author(s):  
David Hervás-Marín ◽  
Faatiemah Higgins ◽  
Onofre Sanmartín ◽  
Jose Antonio López-Guerrero ◽  
M. Carmen Bañó ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Global Scale ◽  
Good Prognosis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Low Risk ◽  
Major Interest

ABSTRACTCutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer. Although most cSCCs have good prognosis, a subgroup of high-risk cSCC has a higher frequency of recurrence and mortality. Therefore, the identification of molecular risk factors associated with this aggressive subtype is of major interest. In this work we carried out a global-scale approach to investigate the DNA-methylation profile in patients at different stages, from premalignant actinic keratosis to low-risk invasive and high-risk non-metastatic and metastatic cSCC. The results showed massive non-sequential changes in DNA-methylome and identified a minimal methylation signature that discriminates between stages. Importantly, a direct comparison of low-risk and high-risk stages revealed epigenetic traits characteristic of high-risk tumours. Finally, a prognostic prediction model in cSCC patients identified a methylation signature able to predict the overall survival of patients. Thus, the analysis of DNA-methylation in cSCC revealed changes during the evolution of the disease through the different stages that can be of great value not only in the diagnosis but also in the prognosis of the disease.

scholarly journals Aberrant DNA Methylation in Cutaneous Squamous Cell Carcinoma

2019 ◽  
Vol 2 (4) ◽  
pp. 227-232
Author(s):  
Feng-Juan Li ◽  
Yi Wu ◽  
Qun Lv ◽  
Xue-Yuan Yang ◽  
Ming-Jun Jiang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Aberrant Dna Methylation
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