scholarly journals ASLPrep: A Generalizable Platform for Processing of Arterial Spin Labeled MRI and Quantification of Regional Brain Perfusion

2021 ◽  
Author(s):  
Azeez Adebimpe ◽  
Maxwell Bertolero ◽  
Sudipto Dolui ◽  
Matthew Cieslak ◽  
Kristin Murtha ◽  
...  

Arterial spin labeled (ASL) magnetic resonance imaging (MRI) is the primary method for non-invasively measuring regional brain perfusion in humans. We introduce ASLPrep, a suite of software pipelines that ensure the reproducible and generalizable processing of ASL MRI data

Toxics ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 353
Author(s):  
Hoa Thi Vu ◽  
Thao Ngoc Pham ◽  
Takashi Yokawa ◽  
Muneko Nishijo ◽  
Tai Pham The ◽  
...  

To clarify the influence of dioxin exposure on brain morphometry, the present study investigated associations between dioxin exposure at high levels and brain structural irregularities in 32 Vietnamese men. Two exposure markers were used: blood dioxin levels, as a marker of exposure in adulthood, and perinatal dioxin exposure, estimated by maternal residency in a dioxin-contaminated area during pregnancy. All subjects underwent brain magnetic resonance imaging (MRI) scans. We analyzed correlations between regional gray matter volumes and blood dioxin levels, and compared regional volumes between men with and without perinatal dioxin exposure using the voxel-based morphometry (VBM) tool from Statistical Parametric Mapping 12 (SPM12). Blood 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with low volume of the medial temporal pole and fusiform gyrus. Toxic equivalency (TEQ)-PCDDs were correlated with low medial temporal pole volume. However, 1,2,3,4,7,8-HxCDD was associated with high middle frontal gyrus and cerebellum volume. In men with perinatal dioxin exposure, the left inferior frontal gyrus pars orbitalis volume was significantly lower than in those without perinatal exposure. These results suggest that dioxin exposure during the perinatal period and in adulthood may alter regional brain volume, which might lead to cognitive deficits and unusual social emotional behavior in Vietnamese men living in dioxin-contaminated areas.


2012 ◽  
Vol 8 (1) ◽  
pp. 14
Author(s):  
Marco Essig ◽  
Lawrence Tanenbaum ◽  
◽  

Early intervention remains vital in the management of acute stroke. The goals of imaging techniques are to establish a diagnosis as early as possible and to obtain accurate information about the intracranial vasculature and brain perfusion to guide therapeutic decisionmaking. Magnetic resonance imaging (MRI) and contrast-enhanced magnetic resonance angiography (CE-MRA) are valuable techniques in the evaluation of acute stroke and can provide diagnostic information on the underlying pathophysiological changes. Gadolinium-based contrast agents (GBCAs) facilitate the diagnosis of ischaemic stroke by accentuating abnormal flow kinetics and the diagnosis of nonischaemic stroke by assisting in the detection and characterisation of intracranial aneurysms and arteriovenous malformations (AVMs). Contrast agents may also be employed in the characterisation of vascular atherosclerotic plaque. Gadobutrol (Gadovist®, Gadavist®) is a high relaxivity contrast agent which combines an excellent safety profile and proven high efficacy. As the only high concentration contrast media it allows to inject at a small and compact bolus, which has a direct impact on the performance of MRA or perfusion MRI procedure.


2019 ◽  
Vol 23 (04) ◽  
pp. 405-418 ◽  
Author(s):  
James F. Griffith ◽  
Radhesh Krishna Lalam

AbstractWhen it comes to examining the brachial plexus, ultrasound (US) and magnetic resonance imaging (MRI) are complementary investigations. US is well placed for screening most extraforaminal pathologies, whereas MRI is more sensitive and accurate for specific clinical indications. For example, MRI is probably the preferred technique for assessment of trauma because it enables a thorough evaluation of both the intraspinal and extraspinal elements, although US can depict extraforaminal neural injury with a high level of accuracy. Conversely, US is probably the preferred technique for examination of neurologic amyotrophy because a more extensive involvement beyond the brachial plexus is the norm, although MRI is more sensitive than US for evaluating muscle denervation associated with this entity. With this synergy in mind, this review highlights the tips for examining the brachial plexus with US and MRI.


Endoscopy ◽  
2004 ◽  
Vol 36 (10) ◽  
Author(s):  
BP McMahon ◽  
JB Frøkjær ◽  
A Bergmann ◽  
DH Liao ◽  
E Steffensen ◽  
...  

2019 ◽  
pp. 10-23
Author(s):  
T. A. Akhadov ◽  
S. Yu. Guryakov ◽  
M. V. Ublinsky

For a long time, there was a need to apply magnetic resonance imaging (MRI) technique for lung visualization in clinical practice. The development of this method is stimulated by necessity of the emergence of an alternative to computed tomography, especially when radiation and injection of iodine-containing contrast agents are contraindicated or undesirable, for example, in pregnant women and children, people with intolerance to iodinated contrast. One of the reasons why lung MRI is still rarely used is lack of elaborated standardized protocols that would be adapted to clinical needs of medical society. This publication is a current literature review on the use of MRI in lung studies.


2007 ◽  
Vol 30 (4) ◽  
pp. 41
Author(s):  
A. Dechant

On the morning of October 10, 2003, the residents of New York awoke to find that an entire page of their beloved paper, The Times, had been usurped for the sole purpose of flagrant self-promotion and protestation. On his own behalf, Dr. Raymand Damadian had purchased a one page spread bemoaning his exclusion in the Nobel Prize for Medicine that year which had previously been awarded to Paul Laterbur and Peter Mansfield for their contributions to the development of Magnetic Resonance Imaging (MRI). Over the course of the next few months, the public was to witness a series of such articles proclaiming that a shameful wrong had been committed, and that the truth would eventually prove Dr. Damadian’s accusations. That truth lay in the early theoretical and technical foundations that led to the discovery of MRI. Described just after the Second World War, nuclear magnetic resonance (NMR) was hailed as a breakthrough in physical chemistry for which Felix Bloch and Edward Purcell were awarded the Nobel Prize in Physics in 1952. Two decades later, in 1971, Dr. Damadian discovered that differences between the NMR signals of cancerous and normal tissue might provide a rapid means of cancer detection. However, Laterbur and Mansfield were the first to actually demonstrate images of live tissue using the application of magnetic gradients – the key to modern MRI. Though speculation exists that Dr. Damadian may have been excluded from the prize due to his religious beliefs or political rivalry, only time will reveal the whole truth when the Nobel files are opened 50 years hence. Bradley W. The Nobel Prize: Three Investigators Allowed but Two Were Chosen. Journal of Magnetic Resonance Imaging 2004; 19:520. Laterbur P. Image formation by induced local interactions: examples of employing nuclear magnetic resonance. Nature 1973; 242:190-191. Mansfield P, Grannell P. “NMR diffraction in solids?” Journal of Physics C: Solid State Physics 1973; 63:L433-L426.


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