scholarly journals Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer's disease

2021 ◽  
Author(s):  
Grace E Weber ◽  
Maria Khrestian ◽  
Elizabeth D Tuason ◽  
Yvonne Shao ◽  
Jagan Pillai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Immune Response ◽  
Cerebrospinal Fluid ◽  
Genetic Variants ◽  
Exploratory Study ◽  
Inflammatory Activity ◽  
Early Stages ◽  
Peripheral Immune Response ◽  
The Relationship

Alzheimer's disease (AD) has been linked to multiple immune system genetic variants, implicating potential broad alterations in inflammatory profiles in the disease. Triggering receptor expressed on myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. A soluble TREM2 isoform (sTREM2) is elevated in cerebrospinal fluid in the early stages of AD suggesting it may be a biomarker of progressive alterations in immune response to AD-related pathology. Multiple studies have reported an altered peripheral immune response in AD. However, less is known about the relationship between plasma sTREM2 and the altered peripheral immune response in AD. The objective of this exploratory study was to examine the relationship between sTREM2 and inflammatory activity in human participants defined by clinically characterized cognitive symptoms and groups defined by the cerebrospinal fluid biomarkers amyloid beta, phosphorylated tau, and neurodegeneration (NIA-AA Research Framework: "ATN continuum".) The hypothesis of this exploratory study was that sTREM2 related inflammatory activity differs by AD stage. We observed different patterns of inflammatory activity across disease groups and ATN categories that implicates peripheral sTREM2 related inflammatory activity as altered in the early stages of AD. Notably, fractalkine showed a significant relationship with sTREM2 across different analyses in the control groups that was lost as disease progressed, and fractalkine, IL-5 and IL-17A were decreased in AD. These preliminary data provide important support to the hypothesis that sTREM2-related inflammatory activity is a stage-specific biomarker of AD progression, providing the groundwork for future studies and therapeutic strategies.

scholarly journals Decreased Cerebrospinal Fluid Levels of L-Carnitine in Non-Apolipoprotein E4 Carriers at Early Stages of Alzheimer's Disease

2014 ◽  
Vol 41 (1) ◽  
pp. 223-232 ◽  
Author(s):  
María Lodeiro ◽  
Clara Ibáñez ◽  
Alejandro Cifuentes ◽  
Carolina Simó ◽  
Ángel Cedazo-Mínguez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Levels ◽  
Apolipoprotein E4 ◽  
Early Stages ◽  
Fluid Levels

P4-210: DISENTANGLING THE RELATIONSHIP BETWEEN SYNAPTIC AND NEURODEGENERATION CEREBROSPINAL FLUID BIOMARKERS IN ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P1356-P1357
Author(s):  
Olivia Belbin ◽  
Daniel Alcolea ◽  
Ignacio Illán-Gala ◽  
Raúl Núñez-Llaves ◽  
Laia Muñoz-Llahuna ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Biomarkers ◽  
The Relationship

scholarly journals Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer’s Disease Cerebrospinal Fluid Biomarkers

2018 ◽  
Vol 66 (2) ◽  
pp. 639-652 ◽  
Author(s):  
Mafalda Ramos de Matos ◽  
Catarina Ferreira ◽  
Sanna-Kaisa Herukka ◽  
Hilkka Soininen ◽  
André Janeiro ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Quantitative Genetics ◽  
Genetic Variants ◽  
Cerebrospinal Fluid Biomarkers

SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease

2012 ◽  
Vol 262 (6) ◽  
pp. 529-534 ◽  
Author(s):  
Liang-Hao Guo ◽  
Christine Westerteicher ◽  
Xin-Hui Wang ◽  
Martina Kratzer ◽  
Amalia Tsolakidou ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Genetic Variants ◽  
Cerebrospinal Fluid Biomarkers

BACE1 and Other Alzheimer’s-Related Biomarkers in Cerebrospinal Fluid and Plasma Distinguish Alzheimer’s Disease Patients from Cognitively-Impaired Neurosyphilis Patients

2020 ◽  
Vol 77 (1) ◽  
pp. 313-322 ◽  
Author(s):  
Min Zhang ◽  
Xiaomei Zhong ◽  
Haishan Shi ◽  
Eugeen Vanmechelen ◽  
Ann De Vos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Cognitive Function ◽  
Amyloid Β ◽  
Cognitively Impaired ◽  
Protein Levels ◽  
Scale Scores ◽  
Early Biomarker ◽  
The Relationship

Background: Patients with spirochetal infection, which causes neurosyphilis (NS) and at a later stage general paresis of the insane (GPI), present with brain pathology features of Alzheimer’s disease (AD). However, the relationships among these illnesses regarding biomarker levels are still unclear. Objective: To explore biomarker levels in NS and GPI compared with those in AD and the relationship between biomarker levels and cognitive function in NS and GPI. Methods: Levels of neurogranin (NGRN) and β-amyloid precursor protein cleaving enzyme (BACE1) in cerebrospinal fluid (CSF)/plasma, together with amyloid-β 1–40 (Aβ40), Aβ42, and total tau in the CSF of 23 AD patients, 55 GPI patients, and 13 NS patients were measured. Patients were classified into none-to-mild, moderate, and severe stages of cognitive impairment. Results: Levels of CSF NGRN, BACE1, and tau as well as plasma BACE1 levels were significantly different among groups. In the none-to-mild stage, plasma BACE1 levels correlated with the protein levels in CSF and were significantly increased in AD patients versus GPI patients. The CSF tau levels in AD patients were significantly increased versus GPI patients in the moderate and severe stages. Pooling data from GPI and NS patients, both CSF tau and plasma NGRN levels correlated with cognitive scale scores. Conclusion: GPI and NS patients might have different biomarker level patterns compared to AD patients. While plasma BACE1 could be a promising early biomarker for distinguishing AD from GPI, CSF tau and plasma NGRN levels might be valuable in indications of cognitive function in pooled NS populations.

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