scholarly journals Genotype-specific Features Reduce the Susceptibility of South American Yellow Fever Virus Strains to Vaccine-Induced Antibodies

2021 ◽  
Author(s):  
Denise Haslwanter ◽  
Gorka Lasso ◽  
Anna Z Wec ◽  
Nathalia Dias Furtado ◽  
Lidiane Menezes Souza Raphael ◽  
...  
Keyword(s):  
South America ◽  
Yellow Fever ◽  
Neutralizing Antibodies ◽  
Yellow Fever Virus ◽  
Glycosylation Site ◽  
Etiologic Agent ◽  
Fever Virus ◽  
South American ◽  
Genetic Changes ◽  
Immunological Surveillance

The resurgence of yellow fever in South America has prompted mitigation through vaccination against the etiologic agent, yellow fever virus (YFV). Current vaccines are based on a virulent African isolate, and their capacity to induce neutralizing antibodies against the vaccine strain is widely used as a surrogate for protection. However, the sensitivity of genetically distinct South American strains to vaccine-induced antibodies is unknown. Here, we show that antiviral potency of the polyclonal antibody response in both U.S. and Brazilian vaccinees is attenuated against an emergent Brazilian strain. This reduction was attributable to genetic changes at two sites in the central domain II of the glycoprotein E, including the acquisition of an N linked glycosylation site, which are unique to and shared among most South American YFV strains. Our findings call for a reevaluation of current approaches to YFV immunological surveillance in South America and suggest approaches for designing updated vaccines.

scholarly journals Cutaneous lesions caused by the yellow fever vaccine – have you ever seen them?

2018 ◽  
Vol 64 (6) ◽  
pp. 498-500 ◽  
Author(s):  
Michelle Larissa Zini Lise ◽  
Michael Laurence Zini Lise
Keyword(s):  
Side Effects ◽  
South America ◽  
Skin Rash ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Yellow Fever Vaccine ◽  
Cutaneous Lesions ◽  
Tropical Regions

SUMMARY The Yellow Fever virus was isolated in 1927 and the disease is considered endemic and epidemic in tropical regions of South America and Africa, with thousands of new cases reported annually. Several side effects of the vaccine have already been reported. Although reports of skin rash secondary to the vaccine range from 0 to 15%, no image or detailed description of the lesions were found in the literature. Here we describe a rash on a toddler vaccinated to travel.

scholarly journals Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults

2017 ◽  
Vol 59 (0) ◽  
Author(s):  
Karina Takesaki Miyaji ◽  
Vivian Iida Avelino-Silva ◽  
Marisol Simões ◽  
Marcos da Silva Freire ◽  
Carlos Roberto de Medeiros ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Neutralizing Antibodies ◽  
Yellow Fever Virus ◽  
Fever Virus

scholarly journals A Yellow Fever Virus 17D Infection and Disease Mouse Model Used to Evaluate a Chimeric Binjari-Yellow Fever Virus Vaccine

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 368 ◽  
Author(s):  
Kexin Yan ◽  
Laura J. Vet ◽  
Bing Tang ◽  
Jody Hobson-Peters ◽  
Daniel J. Rawle ◽  
...  
Keyword(s):  
Weight Loss ◽  
Mouse Model ◽  
Yellow Fever ◽  
Virus Vaccine ◽  
Neutralizing Antibodies ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Liver Pathology ◽  
Vaccine Production ◽  
Mosquito Cells

Despite the availability of an effective, live attenuated yellow fever virus (YFV) vaccine (YFV 17D), this flavivirus still causes up to ≈60,000 deaths annually. A number of new approaches are seeking to address vaccine supply issues and improve safety for the immunocompromised vaccine recipients. Herein we describe an adult female IFNAR-/- mouse model of YFV 17D infection and disease that recapitulates many features of infection and disease in humans. We used this model to evaluate a new YFV vaccine that is based on a recently described chimeric Binjari virus (BinJV) vaccine technology. BinJV is an insect-specific flavivirus and the chimeric YFV vaccine (BinJ/YFV-prME) was generated by replacing the prME genes of BinJV with the prME genes of YFV 17D. Such BinJV chimeras retain their ability to replicate to high titers in C6/36 mosquito cells (allowing vaccine production), but are unable to replicate in vertebrate cells. Vaccination with adjuvanted BinJ/YFV-prME induced neutralizing antibodies and protected mice against infection, weight loss and liver pathology after YFV 17D challenge.

scholarly journals Yellow Fever Virus Maintenance in Trinidad and Its Dispersal throughout the Americas

2010 ◽  
Vol 84 (19) ◽  
pp. 9967-9977 ◽  
Author(s):  
Albert J. Auguste ◽  
Philippe Lemey ◽  
Oliver G. Pybus ◽  
Marc A. Suchard ◽  
Rosa Alba Salas ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Weak Link ◽  
Fever Virus ◽  
Complete Analysis ◽  
Recent Common Ancestor ◽  
Source Population ◽  
South American ◽  
Most Recent Common Ancestor

ABSTRACT Trinidad, like many other American regions, experiences repeated epizootics of yellow fever virus (YFV). However, it is unclear whether these result from in situ evolution (enzootic maintenance) or regular reintroduction of YFV from the South American mainland. To discriminate between these hypotheses, we carried out a Bayesian phylogeographic analysis of over 100 prM/E gene sequences sampled from 8 South American countries. These included newly sequenced isolates from the recent 2008-2009 Trinidad epizootic and isolates derived from mainland countries within the last decade. The results indicate that the most recent common ancestor of the 2008-2009 epizootic existed in Trinidad 4.2 years prior to 2009 (95% highest probability density [HPD], 0.5 to 9.0 years). Our data also suggest a Trinidad origin for the progenitor of the 1995 Trinidad epizootic and support in situ evolution of YFV between the 1979 and 1988-1989 Trinidad epizootics. Using the same phylogeographic approach, we also inferred the historical spread of YFV in the Americas. The results suggest a Brazilian origin for YFV in the Americas and an overall dispersal rate of 182 km/year (95% HPD, 52 to 462 km/year), with Brazil as the major source population for surrounding countries. There is also strong statistical support for epidemiological links between four Brazilian regions and other countries. In contrast, while there were well-supported epidemiological links within Peru, the only statistically supported external link was a relatively weak link with neighboring Bolivia. Lastly, we performed a complete analysis of the genome of a newly sequenced Trinidad 2009 isolate, the first complete genome for a genotype I YFV isolate.

Detection of a new yellow fever virus lineage within the South American genotype I in Brazil

2010 ◽  
Vol 82 (1) ◽  
pp. 175-185 ◽  
Author(s):  
Renato P. de Souza ◽  
Peter G. Foster ◽  
Maria Anice M. Sallum ◽  
Terezinha L.M. Coimbra ◽  
Adriana Y. Maeda ◽  
...  
Keyword(s):  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
South American ◽  
The South ◽  
Genotype I
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