scholarly journals Macula structural and vascular differences in glaucoma eyes with and without high axial myopia

2021 ◽  
Author(s):  
Jasmin Rezapour ◽  
Christopher Bowd ◽  
Jade Dohleman ◽  
Akram Belghith ◽  
James A. Proudfoot ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Axial Length ◽  
Plexiform Layer ◽  
Positive Association ◽  
Mean Deviation ◽  
Ganglion Cell Complex ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Axial Myopia

AbstractAimsTo assess the thickness of various retinal layers, and the superficial vessel density (sVD) in the macula of glaucomatous eyes and their associations with axial length (AL) and visual field mean deviation (VFMD) to identify parameters useful for glaucoma management in myopic eyes.Methods248 glaucoma patients (401 eyes) participating in the Diagnostic Innovations in Glaucoma Study observational cohort representing 3 axial myopia groups (non-myopia: n=146 eyes; mild myopia: n=208 eyes; high myopia (AL>26 mm): n=47 eyes) who completed macular OCT and OCT-Angiography imaging were included. The cross-sectional associations of AL and VFMD with the thickness of the ganglion cell inner plexiform layer (GCIPL), macular retinal nerve fiber layer (mRNFL), ganglion cell complex (GCC), sVD and macular choroidal thickness (mCT) were evaluated.ResultsThinner Global GCIPL and GCC were significantly associated with worse VFMD (R2=35.1%; and R2=33.4%; respectively p<0.001), but not with AL (all p>0.350). Thicker mRNFL showed a weak association with increasing AL (R2=3.4%; p=0.001) and a positive association with VFMD (global R2=20.5%; p<0.001). Lower sVD was weakly associated with increasing AL (R2=2.3%; p=0.016) and more strongly associated with more severe glaucoma VFMD (R2=31.8%; p<0.001). Thinner mCT was associated with increasing AL (R2=17.3% p<0.001) and not associated with VFMD (P=0.262). mRNFL was thickest while mCT was thinnest in all sectors of high myopic eyes.ConclusionsGCIPL and GCC thinned with increasing severity of glaucoma but were not significantly associated with axial length. GCIPL and GCC thickness may be useful clinical parameters to identify glaucoma in myopic eyes.

scholarly journals The Pattern of Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness Changes in Glaucoma

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Jin A Choi ◽  
Hye-Young Shin ◽  
Hae-Young Lopilly Park ◽  
Chan Kee Park
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Plexiform Layer ◽  
Mean Deviation ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Advanced Glaucoma ◽  
Retinal Nerve Fiber

Background/Aims. To investigate the patterns of retinal ganglion cell damage at different stages of glaucoma, using the circumpapillary retinal nerve fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses. Methods. In 296 eyes of 296 glaucoma patients and 55 eyes of 55 healthy controls, the correlations of mean deviation (MD) with the superior and inferior quadrant RNFL/GCIPL thickness (defined as the average of three superior and inferior sectors, resp.) were analyzed. Results. In early to moderate glaucoma, most of the RNFL/GCIPL thicknesses had significant positive correlations with the MD. In advanced glaucoma, the superior GCIPL thickness showed the highest correlation with MD (r=0.495), followed by the superior RNFL (r=0.452) (all; P<0.05). The correlation coefficient of the inferior RNFL thickness with MD (r<0.471) was significantly stronger in early to moderate glaucoma compared to that in advanced glaucoma (r=0.192; P<0.001). In contrast, the correlations of the superior GCIPL thickness with MD (r=0.452) in advanced glaucoma was significantly stronger compared to that in early to moderate glaucoma (r=0.159; P<0.001). Conclusions. The most preserved region in advanced glaucoma appears to be the superior macular GCIPL, whereas the most vulnerable region for initial glaucoma is the inferior RNFL around the optic disc.

scholarly journals Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jiyun Lee ◽  
Chan Kee Park ◽  
Hae-Young Lopilly Park
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Deep Layer ◽  
Plexiform Layer ◽  
Normal Tension Glaucoma ◽  
Mean Deviation ◽  
Inner Plexiform Layer ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Cross Sectional

AbstractWe investigated the characteristics of localized vessel density defects (VD) either in the deep or superficial vascular layer of normal-tension glaucoma patients using optical coherence tomography angiography (OCTA). In this retrospective, cross-sectional study, 74 eyes with localized retinal nerve fiber layer (RNFL) defect were included. The relationships between the widths of the VD in the superficial and deep layer and ocular factors were evaluated. Eyes with greater deep VD were significantly older (P = 0.023). The IOP measured at OCTA exam was significantly related to the width of the deep VD (P = 0.009). By contrast, average ganglion cell inner plexiform layer thickness (GCIPLT) was substantially related to the width of the superficial VD (P = 0.004). In logistic regression analysis, aging was noticeably associated with wider deep VD, whereas worse mean deviation (MD) had a significant association with wider superficial VD (P = 0.001, P = 0.003, respectively). In sum, while changes of the superficial layer seemed an overall ramification of glaucomatous damages, the deep layer was more likely to be affected by factors related to ocular microcirculation, such as IOPs and older age. Thus, looking into the deep vascular layer using OCTA could identify risk factors related to the disturbance in ocular microcirculation.

scholarly journals Analysis of axial length, retinal nerve fiber layer, macular area and estimated retinal ganglion cell count in myopic preperimetric glaucomatous eyes: an observational study

2020 ◽  
Author(s):  
Teresa Rolle ◽  
Beatrice Bonetti ◽  
Alberto Mazzucco ◽  
Laura Dallorto
Keyword(s):  
Observational Study ◽  
Ganglion Cell ◽  
Sensitivity And Specificity ◽  
Axial Length ◽  
Ganglion Cells ◽  
Ganglion Cell Complex ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Diagnostic Ability ◽  
Cross Sectional

Abstract BACKGROUND: The aim of the study is to evaluate the diagnostic ability of OCT parameters and retinal ganglion cells (RGCs) count in identify glaucomatous disease in myopic preperimetric eyes.METHODS: This was a cross-sectional observational study. The study group consisted of 154 eyes: 36 healthy, 64 preperimetric (PPG), and 54 primary openangle glaucoma (POAG) eyes. Each group was divided into three subgroups based on axial length: emmetropic, myopic with axial length (AL) <25 mm, and myopic with AL>25 mm, to analyze the effect of myopia. The RGCs count was obtained using a model described later. As regard the influence of myopia on OCT parameters and RGC count, we performed Pearson’s correlation. The Area Under Receiver Operator Characteristics Curves (AUROC curves) evaluated which parameter had the best sensitivity and specificity in identifying glaucoma in myopic eyes.RESULTS: In Pearson’s test, all Ganglion Cell Complex (GCC) thicknesses showed the weakest and less significant correlation with AL in all groups. All the AUROCs were statistically significant, and above 0.5. Inferior GCC and Global Loss Volume (GLV) showed the highest AUCs in all myopic group and the best diagnostic ability in distinguishing healthy from glaucomatous eyes. RGCcount showed good AUROC in all groups, with sensitivities of about 83% in myopic eyes, and specificity over 91% in all groups.CONCLUSIONS: GCC is the parameter less influenced by the AL, and the inferior GCC and the GLV have the best diagnostic performance. The RGCcount has good sensitivity and specificity, so it can be used as a complementary test in the diagnosis of glaucoma in myopic preperimetric eyes.

scholarly journals The Analysis of Intra-retinal Layers with Automatic Optical Coherence Tomography Segmentation in Healthy Subjects

2019 ◽  
pp. 1-13
Author(s):  
Osman Ahmet Polat ◽  
Ali Kurt ◽  
Raşit Kılıç ◽  
Özkan Kocamış
Keyword(s):  
Axial Length ◽  
Pigment Epithelium ◽  
Outer Nuclear Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Positive Correlation ◽  
Retinal Layers ◽  
Department Of Ophthalmology

Aims: To give normative databases of each retinal layers on OCT images in the healthy Caucasian population in Turkey and investigate the relevance of the data with factors such as age, gender, axial length and refraction. Study Design: Prospective, cross sectional, descriptive study. Place and Duration of Study: Department of Ophthalmology, Faculty of Medicine, Kirsehir Ahi Evran University, Kirsehir/TURKEY. Between September 2017 and March 2018. Methodology: 133 participants underwent full ophthalmologic examination and spectral domain OCT imaging (Spectralis, Heidelberg Engineering, Germany). After the automatic segmentation, central 1 mm and 1-3 mm superior, inferior, nasal and temporal thicknesses of retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retina pigment epithelium (RPE), inner retinal layers (IRL), outer retinal layers (ORL) and total retina thickness (TRT) analyzed with respect to age, gender, axial length and refraction (spherical equivalent). Results: Central 1 mm INL, ONL, ORL, IRL and TRT and four quadrants of pericentral 1-3 mm thicknesses of RPE had positive correlation with the age. All the sections of total retina, RNFL, GCL, IPL, INL, ONL and IRL thicknesses were significantly thicker in males compared to females. The thicknesses of all RNFL sections and central 1 mm circle thicknesses of TRT, IPL, INL, OPL, RPE and IRL had positive correlation with the axial length. Conclusion: A normative database for thicknesses of intra-retinal layers in Turkish population was presented in the study and significant impacts of the age, gender and axial length were presented.

scholarly journals Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis

2014 ◽  
Vol 20 (10) ◽  
pp. 1331-1341 ◽  
Author(s):  
Divya Narayanan ◽  
Han Cheng ◽  
Karlie N Bonem ◽  
Roberto Saenz ◽  
Rosa A Tang ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Ganglion Cell ◽  
Layer Thickness ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Permanent Disability ◽  
Progressive Neurodegeneration

Background: Neurodegeneration plays an important role in permanent disability in multiple sclerosis (MS). Objective: The objective of this paper is to determine whether progressive neurodegeneration occurs in MS eyes without clinically evident inflammation. Methods: Retinal nerve fiver layer thickness (RNFLT) and ganglion cell-inner plexiform layer thickness (GCIPT) were measured using Cirrus optical coherence tomography (OCT) in 133 relapsing–remitting MS (RRMS) patients (149 non-optic neuritis (ON), 97 ON eyes, last ON ≥6 months). Ninety-three patients were scanned at two visits. Percentages of abnormal GCIPT vs RNFLT (<5% of machine norms) in cross-sectional data were compared. Relations between RNFLT/GCIPT and MS duration (cross-sectional) and follow-up time (longitudinal) were assessed. Results: GCIPT was abnormal in more eyes than RNFLT (27% vs 16% p = 0.004 in non-ON, 82% vs 72% p = 0.007 in ON). RNFLT and GCIPT decreased with MS duration by −0.49 µm/yr ( p = 0.0001) and −0.36 ( p = 0.005) for non-ON; −0.52 ( p = 0.003) and −0.41 ( p = 0.007) for ON. RNFLT and GCIPT decreased with follow-up time by −1.49 µm/yr ( p < 0.0001) and −0.53 ( p = 0.004) for non-ON, −1.27 ( p = 0.002) and −0.49 ( p = 0.04) for ON. Conclusions: In RRMS eyes without clinically evident inflammation, progressive loss of RNFLT and GCIPT occurred, supporting the need for neuroprotection in addition to suppression of autoimmune responses and inflammation.

scholarly journals Evidence of subclinical quantitative retinal layer abnormalities in AQP4-IgG seropositive NMOSD

2020 ◽  
pp. 135245852097777
Author(s):  
Angeliki G Filippatou ◽  
Eleni S Vasileiou ◽  
Yufan He ◽  
Kathryn C Fitzgerald ◽  
Grigorios Kalaitzidis ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Outer Nuclear Layer ◽  
Sensitivity Analyses ◽  
Retinal Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Foveal Thickness ◽  
Cross Sectional ◽  
Photoreceptor Layer ◽  
History Of

Background: Prior studies have suggested that subclinical retinal abnormalities may be present in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (NMOSD), in the absence of a clinical history of optic neuritis (ON). Objective: Our aim was to compare retinal layer thicknesses at the fovea and surrounding macula between AQP4-IgG+ NMOSD eyes without a history of ON (AQP4-nonON) and healthy controls (HC). Methods: In this single-center cross-sectional study, 83 AQP4-nonON and 154 HC eyes were studied with spectral-domain optical coherence tomography (OCT). Results: Total foveal thickness did not differ between AQP4-nonON and HC eyes. AQP4-nonON eyes exhibited lower outer nuclear layer (ONL) and inner photoreceptor segment (IS) thickness at the fovea (ONL: −4.01 ± 2.03 μm, p = 0.049; IS: −0.32 ± 0.14 μm, p = 0.029) and surrounding macula (ONL: −1.98 ± 0.95 μm, p = 0.037; IS: −0.16 ± 0.07 μm, p = 0.023), compared to HC. Macular retinal nerve fiber layer (RNFL: −1.34 ± 0.51 μm, p = 0.009) and ganglion cell + inner plexiform layer (GCIPL: −2.44 ± 0.93 μm, p = 0.009) thicknesses were also lower in AQP4-nonON compared to HC eyes. Results were similar in sensitivity analyses restricted to AQP4-IgG+ patients who had never experienced ON in either eye. Conclusions: AQP4-nonON eyes exhibit evidence of subclinical retinal ganglion cell neuronal and axonal loss, as well as structural evidence of photoreceptor layer involvement. These findings support that subclinical anterior visual pathway involvement may occur in AQP4-IgG+ NMOSD.

scholarly journals Macular Ganglion Cell–Inner Plexiform Layer Loss Precedes Peripapillary Retinal Nerve Fiber Layer Loss in Glaucoma with Lower Intraocular Pressure

Ophthalmology ◽  
2019 ◽  
Vol 126 (8) ◽  
pp. 1119-1130 ◽  
Author(s):  
Henry N. Marshall ◽  
Nicholas H. Andrew ◽  
Mark Hassall ◽  
Ayub Qassim ◽  
Emmanuelle Souzeau ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Plexiform Layer ◽  
Inner Plexiform Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber
Sign in / Sign up

Export Citation Format

Share Document