scholarly journals RUNIMC: An R-based package for imaging mass cytometry data analysis and pipeline validation

2021 ◽  
Author(s):  
Luigi Dolcetti ◽  
Paul R Barber ◽  
Gregory Weitsman ◽  
Selvam Thavaraj ◽  
Kenrick Ng ◽  
...  
Keyword(s):  
Random Forest ◽  
Gold Standard ◽  
Image Features ◽  
Random Forest Classifier ◽  
Nuclear Staining ◽  
The Novel ◽  
Mass Cytometry ◽  
Random Forest Regression ◽  
Regression Approach ◽  
Expert Classification

We propose a novel pipeline for the analysis of imaging mass cytometry data, comparing an unbiased approach, representing the actual gold standard, with a novel biased method. We made use of both synthetic/ controlled datasets as well as two datasets obtained from FFPE sections of follicular lymphoma, and head and neck patients, stained with a 14 and 29-markers panels respectively. The novel pipeline, denominated RUNIMC, has been completely developed in R and contained in a single package. The novelty resides in the ease with which multi-class random forest classifier can be used to classify image features, making the pathologist and expert classification pivotal, and the use of a random forest regression approach that permits a better detection of cell boundaries, and alleviates the necessity of relying on a perfect nuclear staining.

scholarly journals Heart Disease Prediction using Machine Learning Techniques

2019 ◽  
Vol 8 (4) ◽  
pp. 10316-10320
Keyword(s):  
Machine Learning ◽  
Heart Disease ◽  
Random Forest ◽  
Descriptive Analysis ◽  
Random Forest Classifier ◽  
Machine Learning Techniques ◽  
Decision Tree Classifier ◽  
Random Forest Regression ◽  
Learning Techniques ◽  
Tree Classifier

Nowadays, heart disease has become a major disease among the people irrespective of the age. We are seeing this even in children dying due to the heart disease. If we can predict this even before they die, there may be huge chances of surviving. Everybody has various qualities of beat rate (pulse rate) and circulatory strain (blood pressure). We are living in a period of data. Due to the rise in the technology, the amount of data that is generated is increasing daily. Some terabytes of data are being produced and stored. For example, the huge amount of data about the patients is produced in the hospitals such as chest pain, heart rate, blood pressure, pulse rate etc. If we can get this data and apply some machine learning techniques, we can reduce the probability of people dying. In this paper we have done survey using different classification and grouping strategies, for example, KNN, Decision tree classifier, Gaussian Naïve Bayes, Support vector machine, Linear regression, Logistic regression, Random forest classifier, Random forest regression, linear descriptive analysis. We have taken the 14 attributes that are present in the dataset as an input and applying on the dataset which is taken from the UCI repository to develop and accurate model of predicting the heart disease contains colossal (huge) therapeutic (medical) information. In the proposed research, the exhibition of the conclusion model is acquired by using utilizing classification strategies. In this paper proposed an accuracy model to predict whether a person has coronary disease or not. This is implemented by comparing the accuracies of different machine-learning strategies such as KNN, Decision tree classifier, Gaussian Naïve Bayes, SVM, Logistic regression, Random forest classifier, Linear regression, Random forest regression, linear descriptive analysis

The Performance Improvement on 4-FB Face using Random Forest Classifier

2018 ◽  
Vol 10 (5) ◽  
pp. 1-12
Author(s):  
B. Nassih ◽  
A. Amine ◽  
M. Ngadi ◽  
D. Naji ◽  
N. Hmina
Keyword(s):  
Random Forest ◽  
Performance Improvement ◽  
Random Forest Classifier

Methodology for Malware Classification using a Random Forest Classifier

2018 ◽  
Author(s):  
Carlos Domenick Morales-Molina ◽  
Diego Santamaria-Guerrero ◽  
Gabriel Sanchez-Perez ◽  
Hector Perez-Meana ◽  
Aldo Hernandez-Suarez
Keyword(s):  
Random Forest ◽  
Random Forest Classifier ◽  
Malware Classification

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Fully automated analysis combining [18F]-FET-PET and multiparametric MRI including DSC perfusion and APTw imaging: a promising tool for objective evaluation of glioma progression

2021 ◽  
Author(s):  
K. J. Paprottka ◽  
S. Kleiner ◽  
C. Preibisch ◽  
F. Kofler ◽  
F. Schmidt-Graf ◽  
...  
Keyword(s):  
Random Forest ◽  
Tumor Progression ◽  
Automated Analysis ◽  
Random Forest Classifier ◽  
Imaging Modalities ◽  
Amide Proton ◽  
Tumor Board ◽  
Dynamic Susceptibility ◽  
Fet Pet ◽  
Promising Tool

Abstract Purpose To evaluate diagnostic accuracy of fully automated analysis of multimodal imaging data using [18F]-FET-PET and MRI (including amide proton transfer-weighted (APTw) imaging and dynamic-susceptibility-contrast (DSC) perfusion) in differentiation of tumor progression from treatment-related changes in patients with glioma. Material and methods At suspected tumor progression, MRI and [18F]-FET-PET data as part of a retrospective analysis of an observational cohort of 66 patients/74 scans (51 glioblastoma and 23 lower-grade-glioma, 8 patients included at two different time points) were automatically segmented into necrosis, FLAIR-hyperintense, and contrast-enhancing areas using an ensemble of deep learning algorithms. In parallel, previous MR exam was processed in a similar way to subtract preexisting tumor areas and focus on progressive tumor only. Within these progressive areas, intensity statistics were automatically extracted from [18F]-FET-PET, APTw, and DSC-derived cerebral-blood-volume (CBV) maps and used to train a Random Forest classifier with threefold cross-validation. To evaluate contribution of the imaging modalities to the classifier’s performance, impurity-based importance measures were collected. Classifier performance was compared with radiology reports and interdisciplinary tumor board assessments. Results In 57/74 cases (77%), tumor progression was confirmed histopathologically (39 cases) or via follow-up imaging (18 cases), while remaining 17 cases were diagnosed as treatment-related changes. The classification accuracy of the Random Forest classifier was 0.86, 95% CI 0.77–0.93 (sensitivity 0.91, 95% CI 0.81–0.97; specificity 0.71, 95% CI 0.44–0.9), significantly above the no-information rate of 0.77 (p = 0.03), and higher compared to an accuracy of 0.82 for MRI (95% CI 0.72–0.9), 0.81 for [18F]-FET-PET (95% CI 0.7–0.89), and 0.81 for expert consensus (95% CI 0.7–0.89), although these differences were not statistically significant (p > 0.1 for all comparisons, McNemar test). [18F]-FET-PET hot-spot volume was single-most important variable, with relevant contribution from all imaging modalities. Conclusion Automated, joint image analysis of [18F]-FET-PET and advanced MR imaging techniques APTw and DSC perfusion is a promising tool for objective response assessment in gliomas.

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