scholarly journals Race/ethnicity in relation to incident primary open-angle glaucoma characterized by autonomously determined visual field loss patterns

2021 ◽  
Author(s):  
Jae Hee Kang ◽  
Mengyu Wang ◽  
Lisa Frueh ◽  
Bernard A Rosner ◽  
Janey Wiggs ◽  
...  
Keyword(s):  
Visual Field ◽  
Racial Differences ◽  
Health Professionals ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Weighting Coefficient ◽  
Open Angle ◽  
Early Loss ◽  
Hispanic White

Purpose: We used an autonomous algorithm to classify incident visual field (VF) loss patterns in primary open-angle glaucoma (POAG). Subsequently, we compared racial differences in the risk of these regional VF loss patterns. Design/Participants: Participants (n=209,036) from the Nurses Health Study (NHS) (follow-up: 1980-2018); NHS2 (1989-2019); and Health Professionals Follow-up Study (HPFS; 1986-2018), aged ≥40 years and free of glaucoma. Methods: Demographics, medical and lifestyle information was assessed on biennial questionnaires. Incident POAG cases (n=1946) with reproducible Humphrey VF loss were confirmed with medical records. The total deviation information of the earliest reliable VF for each eye with POAG (n=2564) was extracted, and a statistical learning method was used to identified optimal solutions for regional vision loss patterns. Each POAG eye was assigned the VF pattern (archetype) based on the highest weighting coefficient. Multivariable-adjusted hazard ratios (HRs) for POAG of various archetypes and 95% confidence intervals (CIs) were estimated using per-eye Cox proportional hazards models. Covariates included cohort, age, glaucoma family history, socioeconomic status, lifestyle parameters, number of eye exams during follow-up, and medical conditions. False discovery rate (FDR) was used for multiple comparisons. Main outcome measures: POAG based on VF patterns. Results: Mean age was 58 years; 1.3% were Black, 1.2% were Asian, 1.1% were Hispanic-White and 96.4% were non-Hispanic White. We identified 14 archetypes: 1 representing no VF loss, 9 of early loss and 4 of advanced loss patterns. Compared to non-Hispanic Whites, Blacks were at significantly higher risk of POAG with early VF loss archetypes collectively (Blacks: HR=1.96, 95% CI=1.46, 2.63) and at even higher risk for POAG with advanced loss archetypes collectively (Blacks: HR=6.07, 95% CI=3.61, 10.21; p=0.0002 for the two estimates being different); no differences were observed for Asians or Hispanic Whites. For individual VF archetypes, Hispanic-Whites had FDR-significant higher risks of POAG of archetypes showing early paracentral defects and advanced superior loss while Blacks had FDR-significant higher risks of all advanced loss archetypes and 3 early loss patterns, including early paracentral defects. Conclusion: Among health professionals, compared to non-Hispanic-Whites, Blacks and Hispanic-Whites had higher risks of incident POAG with central and advanced VF loss.

scholarly journals Visual field indices and optic disc parameters in a 24-month follow-up of primary open angle glaucoma patients

1999 ◽  
Vol 77 (S229) ◽  
pp. 20-21
Author(s):  
Angelo Macrì ◽  
Maurizio Rolando ◽  
Guido Corallo ◽  
Michele Iester ◽  
Giuseppe Verrastro ◽  
...  
Keyword(s):  
Visual Field ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Visual Field Indices

scholarly journals Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden.

2020 ◽  
Author(s):  
Marcelo Ayala
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Open Angle ◽  
Visual Field Progression ◽  
Exfoliation Glaucoma ◽  
The Difference ◽  
Glaucoma Group

Abstract Background: The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods: Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for three years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24-2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results: The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (-3.17 dB) than in the primary open-angle (-1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p=<0.001). The difference in VFI was calculated for the three years follow-up period. The difference was higher in the exfoliation (-7.65%) than in the primary open (-1.90%) glaucoma group (t-test, p=<0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p=<0.001). Conclusion: The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

scholarly journals Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Marcelo Ayala
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Open Angle ◽  
Visual Field Progression ◽  
Exfoliation Glaucoma ◽  
The Difference ◽  
Glaucoma Group

Abstract Background The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for 3 years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24–2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (− 3.17 dB) than in the primary open-angle (− 1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p = < 0.001). The difference in VFI was calculated for the 3 years follow-up period. The difference was higher in the exfoliation (− 7.65%) than in the primary open (− 1.90%) glaucoma group (t-test, p = < 0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p = < 0.001). Conclusion The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

scholarly journals A comparative study of computerised visual field testing and optic disc morphometric parameters in the follow-up of primary open angle glaucoma

Eye ◽  
1998 ◽  
Vol 12 (6) ◽  
pp. 916-920 ◽  
Author(s):  
Angelo Macri ◽  
Maurizio Rolando ◽  
Guido Corallo ◽  
Michele Iester ◽  
Giuseppe Verrastro ◽  
...  
Keyword(s):  
Visual Field ◽  
Comparative Study ◽  
Optic Disc ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Field Testing ◽  
Morphometric Parameters ◽  
Open Angle ◽  
Visual Field Testing

scholarly journals 5-year outcomes of single iStent (G1) trabecular microbypass implantation with phacoemulsification in moderately advanced primary open angle glaucoma

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257015
Author(s):  
Ejaz Ansari
Keyword(s):  
Visual Field ◽  
Outcome Measures ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Case Series ◽  
Secondary Outcome ◽  
Mean Deviation ◽  
Open Angle ◽  
Severe Stage

Purpose To evaluate the safety and efficacy of combined phacoemulsification and single iStent (G1) (iStent, Glaukos Corp. San Clemente, USA), implantation in moderately advanced primary open angle glaucoma (POAG) with 5-years follow-up. Methods Retrospective, interventional case series. All subjects had POAG and underwent single iStent implantation+ phaco+IOL by a single surgeon, with 5 years follow-up. Primary outcome measures: reduction in intraocular pressure (IOP) and proportion of eyes achieving at least 20% reduction of IOP at 5 years. Secondary outcome measures: number of glaucoma drops at 1 through to 5 years; change in visual field mean deviation (MD) at year 5 compared to baseline. Results 35 eyes of 26 patients were included. Mean (sd) medicated pre-op IOP was 18.5 (3.2) mm Hg on mean (sd) 2.3 (1.0) medications. Mean IOP was reduced to 15.9 (4.5) mm Hg on 2.2 (0.9) drops, 15.0mm (4.5) mm Hg on 2.3 (0.9) drops, 15.6 (3.6) mm Hg on 2.5 (1.0) drops, 15.7 (4.43) mmHg on 2.6 (1.0) drops and 14.7 (3.02) mmHg (P<0.001) on 2.7 (1.14) drops (P = 0.06) from 1 through to 5 years. At year 5, 62% of eyes had achieved at least 20% reduction in IOP. MD reduced from -8 (8.1) dB to -10.7 (13.4) dB over 5 years (p = 0.8) at 0.54dB/ annum. One eye required filtering surgery. There were no sight-threatening complications. Conclusion This study showed sustained IOP reduction and excellent safety profile for single iStent implantation. Uniquely it provides data for a more severe stage of glaucoma, and also visual field data, which indicated no significant change through 5 years.

Intraocular Pressure-Dependent Progression of Visual Field Loss in Advanced Primary Open-Angle Glaucoma: A 15-Year Follow-Up

1993 ◽  
Vol 207 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Motohiro Shirakashi ◽  
Kazuo Iwata ◽  
Shoichi Sawaguchi ◽  
Haruki Abe ◽  
Katsuhiko Nanba
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Visual Field Loss ◽  
Open Angle

scholarly journals Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden.

2020 ◽  
Author(s):  
Marcelo Ayala
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Open Angle ◽  
Visual Field Progression ◽  
Exfoliation Glaucoma ◽  
The Difference ◽  
Glaucoma Group

Abstract Background: The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods: Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for three years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24-2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results: The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (-3.17 dB) than in the primary open-angle (-1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p=<0.001). The difference in VFI was calculated for the three years follow-up period. The difference was higher in the exfoliation (-7.65%) than in the primary open (-1.90%) glaucoma group (t-test, p=<0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p=<0.001). Conclusion: The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

scholarly journals Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden

2020 ◽  
Author(s):  
Marcelo Ayala
Keyword(s):  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Open Angle ◽  
Visual Field Progression ◽  
Exfoliation Glaucoma ◽  
The Difference ◽  
Glaucoma Group

Abstract Background The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for three years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24 − 2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (-3.17 dB) than in the primary open-angle (-1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p = < 0.001). The difference in VFI was calculated for the three years follow-up period. The difference was higher in the exfoliation (-7.65%) than in the primary open (-1.90%) glaucoma group (t-test, p = < 0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p = < 0.001). Conclusion The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

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