scholarly journals Convalescent plasma improves overall survival in patients with B-cell lymphoid malignancies and COVID-19: a longitudinal cohort and propensity score analysis

2022 ◽  
Author(s):  
thomas Hueso ◽  
Anne-Sophie Godron ◽  
Emily Lanoy ◽  
Jerome Pakanowski ◽  
Laura I Levi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Propensity Score ◽  
B Cell ◽  
Hematological Malignancies ◽  
Propensity Score Analysis ◽  
Specific Treatment ◽  
Sensitivity Analyses ◽  
Score Analysis ◽  
Cell Neoplasm ◽  
Anti Cd20

Patients with hematological malignancies and COVID-19 display a high mortality rate. In such patients, immunosuppression due to underlying disease and previous specific treatment impair humoral response, limiting viral clearance. Thus, COVID-19 convalescent plasma (CCP) therapy appears as a promising approach through the transfer of neutralizing antibodies specific to SARS-CoV-2. We report the effect of CCP in a cohort of 112 patients with hematological malignancies and COVID19 and a propensity score analysis on subgroups of patients with B-cell lymphoid disease treated (n=81) or not (n=120) with CCP between 1 May 2020 and 1 April 2021. The overall survival of the whole cohort was 65% [56-74.9] and 77.5% [68.5-87.7] for patients with B-cell neoplasm. Prior anti-CD20 monoclonal antibodies therapy was associated with better overall survival whereas age, high blood pressure, and COVID-19 severity were associated with a poor outcome. After an inverse probability of treatment weighting approach, we observed in anti-CD20 exposed patients with B-cell lymphoid disease a decreased mortality of 63% (95% CI=31%-80%) in the CCP-treated group compared to the CCP-untreated subgroup, confirmed in the other sensitivity analyses. Convalescent plasma may be beneficial in COVID-19 patients with B-cell neoplasm who are unable to mount a humoral immune response.

scholarly journals Impact of history of myomectomy on preterm birth risk in women with a leiomyomatous uterus: a propensity score analysis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Emmanuel Rault ◽  
Pierre Delorme ◽  
François Goffinet ◽  
Aude Girault
Keyword(s):  
Preterm Birth ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Sensitivity Analyses ◽  
Secondary Outcome ◽  
Spontaneous Preterm Birth ◽  
Multivariable Logistic Regression Model ◽  
Score Analysis ◽  
Tertiary Center ◽  
History Of

Abstract Background To evaluate if women with a history of myomectomy have a modified preterm birth risk compared to women with myomas during pregnancy. Methods Retrospective cohort study including all women with a history of myomectomy (operated group) or uterine myomas during pregnancy (unoperated group) who delivered in a tertiary center between January, 2011 and December, 2017. The operated group included women who had a myomectomy history with or without myomas during the ongoing pregnancy. The unoperated group included women with uterine myoma(s) seen on at least one ultrasound during pregnancy without history of myomectomy. The primary outcome was preterm birth < 37 weeks, and the secondary outcome spontaneous preterm birth < 37 weeks. To control for confounding factors, a propensity score approach was used. Two sensitivity analysis were performed, one repeating the analysis using the propensity score after excluding operated women with persistent myomas and one using a classical multivariable logistic regression model. Results The cohort included 576 women: 283 operated women and 293 unoperated women. The rate of preterm birth was similar in the two groups: 12.6% in the unoperated group and 12.0% in the operated group (p = 0.82). No difference in preterm birth risk was shown between unoperated and operated women in the cohort matched on the propensity score: OR 0.86; 95%CI [0.47–1.59]. These results were consistent for spontaneous preterm birth (OR 1.61; 95%CI [0.61–4.23]) and for the sensitivity analyses. Conclusion In women with a leiomyomatous uterus, a history of myomectomy is not associated with a reduced preterm birth risk.

scholarly journals Propensity Score Analysis with Partially Observed Baseline Covariates: A Practical Comparison of Methods for Handling Missing Data

2021 ◽  
Vol 18 (13) ◽  
pp. 6694
Author(s):  
Daniele Bottigliengo ◽  
Giulia Lorenzoni ◽  
Honoria Ocagli ◽  
Matteo Martinato ◽  
Paola Berchialla ◽  
...  
Keyword(s):  
Missing Data ◽  
Propensity Score ◽  
Missing Values ◽  
Propensity Scores ◽  
Propensity Score Analysis ◽  
Expectation Maximization Algorithm ◽  
Missing At Random ◽  
Sensitivity Analyses ◽  
Score Analysis ◽  
Baseline Covariates

(1) Background: Propensity score methods gained popularity in non-interventional clinical studies. As it may often occur in observational datasets, some values in baseline covariates are missing for some patients. The present study aims to compare the performances of popular statistical methods to deal with missing data in propensity score analysis. (2) Methods: Methods that account for missing data during the estimation process and methods based on the imputation of missing values, such as multiple imputations, were considered. The methods were applied on the dataset of an ongoing prospective registry for the treatment of unprotected left main coronary artery disease. The performances were assessed in terms of the overall balance of baseline covariates. (3) Results: Methods that explicitly deal with missing data were superior to classical complete case analysis. The best balance was observed when propensity scores were estimated with a method that accounts for missing data using a stochastic approximation of the expectation-maximization algorithm. (4) Conclusions: If missing at random mechanism is plausible, methods that use missing data to estimate propensity score or impute them should be preferred. Sensitivity analyses are encouraged to evaluate the implications methods used to handle missing data and estimate propensity score.

Abstract 13226: Epinephrine versus Norepinephrine in Cardiac Arrest Patients With Postresuscitation Shock

Circulation ◽  
2021 ◽  
Vol 144 (Suppl_2) ◽  
Author(s):  
Wulfran Bougouin ◽  
Kaci Slimani ◽  
Marie Renaudier ◽  
Yannick Binois ◽  
Marine Paul ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Propensity Score ◽  
Hospital Mortality ◽  
Propensity Score Analysis ◽  
Controlled Trial ◽  
Cerebral Performance Category ◽  
Multivariate Regression Analysis ◽  
Sensitivity Analyses ◽  
Score Analysis ◽  
Hospital Cardiac Arrest

Backgound: Whether epinephrine or norepinephrine is preferable as the continuous intravenous vasopressor used to treat postresuscitation shock is unclear. Objectives: To compare outcomes of patients with postresuscitation shock after out-of-hospital cardiac arrest according to whether the continuous intravenous vasopressor used was epinephrine or norepinephrine. Methods: We conducted an observational multicenter study of consecutive patients managed in 2011-2018 for postresuscitation shock. The primary outcome was all-cause hospital mortality, and secondary outcomes were cardiovascular hospital mortality and unfavorable neurological outcome (Cerebral Performance Category 3 to 5). A multivariate regression analysis and a propensity score analysis were performed, as well as several sensitivity analyses. Results: Of the 766 patients included in five hospitals, 285 (37%) received epinephrine and 481 (63%) norepinephrine. All-cause hospital mortality was significantly higher in the epinephrine group (OR 2.6; 95%CI, 1.4-4.7; P =0.002). Cardiovascular hospital mortality was also higher with epinephrine (aOR 5.5; 95%CI 3.0-10.3; P <0.001), as was the proportion of patients with CPC of 3 to 5 at hospital discharge. Sensitivity analyses produced consistent results. The analysis involving adjustment on a propensity score to control for confounders showed similar findings (aOR 2.1; 95%CI 1.1-4.0; P =0.02). Conclusions: Among patients with postresuscitation shock after out-of-hospital cardiac arrest, use of epinephrine was associated with higher all-cause and cardiovascular-specific mortality, compared with norepinephrine infusion. A randomized controlled trial comparing the two vasopressors in this population is warranted.

scholarly journals Propensity score analysis of overall survival between first‐ and second‐generation EGFR‐TKIs using real‐world data

2020 ◽  
Vol 111 (10) ◽  
pp. 3705-3713
Author(s):  
Kentaro Ito ◽  
Kenta Murotani ◽  
Akihito Kubo ◽  
Eiji Kunii ◽  
Hirokazu Taniguchi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Propensity Score ◽  
Real World ◽  
Second Generation ◽  
Propensity Score Analysis ◽  
Real World Data ◽  
World Data ◽  
Score Analysis ◽  
First And Second Generation ◽  
Egfr Tkis

Effectiveness of platinum-based adjuvant chemotherapy for muscle-invasive bladder cancer: A weighted propensity score analysis.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 392-392
Author(s):  
Fumitaka Shimizu ◽  
Satoru Muto ◽  
Masataka Taguri ◽  
Takeshi Ieda ◽  
Takatsugu Okegawa ◽  
...  
Keyword(s):  
Overall Survival ◽  
Bladder Cancer ◽  
Propensity Score ◽  
Propensity Score Analysis ◽  
Rank Test ◽  
Muscle Invasive Bladder Cancer ◽  
Log Rank Test ◽  
Score Analysis ◽  
Subgroup Analyses ◽  
Muscle Invasive

392 Background: The clinical evidence of adjuvant chemotherapy (AC ) is less robust than neoadjuvant chemotherapy (NAC). However, several surveys suggest that urologists prefer to use AC more frequently than NAC. We evaluate the clinical benefit of adjuvant platinum based chemotherapy following radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) in routine clinical practice. Methods: This observational study was conducted to compare the effectiveness of AC versus observation postcystectomy in patients with clinicallymuscle-invasive BCa. Cancer-specific survival (CSS) and overall survival (OS) between the AC group and RC alone group were compared using Kaplan-Meiyer method and log-rank test. After adjusting for background factors using propensity score weighting, differences in CSS and OS between these two groups were compared. Subgroup analyses by the pathological characteristics were performed. Results: In total, 322 patients were included in this study. Of these, 23% received AC postcystectomy. Clinicopathological characteristics showed that patients in the AC group were pathologically more advanced and were at higher risk than the RC alone group. In the unadjusted population, although it is not significantly, the AC group had lower overall survival (3-years OS; 61.5% vs 73.6%, HR 1.44, p = 0.243, log-rank test, AC vs RC alone). In the weighted propensity score analysis, although it is not significantly, AC group were superior than RC alone groups (OS: HR 0.65, 95%CI 0.39-1.09, p = 0.099, log-rank test, AC vs RC alone). Subgroup analyses showed that AC significantly reduced the hazard ratio of OS and CSS in ≥ pT3, pN+, ly+, and v+ subgroups. Conclusions: The weighted propensity score analyses showed that platinum-based AC might be associated with increased CSS and OS in patients with high-risk invasive BCa.

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