Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2
Keyword(s):
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses (β-CoV). The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activity and genetic knockdown confirmed the essential role of the CSNK2 holoenzyme in β-CoV replication. Spike protein uptake was blocked by CSNK2A inhibition, indicating that antiviral activity was due in part to a suppression of viral entry. CSNK2A inhibition may be a viable target for development of new broad spectrum anti-β-CoV drugs.
2005 ◽
Vol 48
(18)
◽
pp. 5738-5748
◽
Keyword(s):
1999 ◽
Vol 59
(1-6)
◽
pp. 117
2000 ◽
Vol 267
(1)
◽
pp. 427-432
◽
Keyword(s):
2013 ◽
Vol 54
(8)
◽
pp. 775-780
◽
2020 ◽
Vol 11
(SPL1)
◽
Keyword(s):