An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936

ABSTRACTBackgroundThe relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. Additionally, it is of interest whether such contributions are independent of those attributed by the most widely used clinical measure of body mass – the Body Mass Index (BMI).MethodWe tested whether an epigenetic BMI score accounts for inter-individual variation in health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936 (n=903). Weights for the epigenetic BMI score were derived using penalised regression on methylation data from unrelated Generation Scotland participants (n=2566).ResultsThe Epigenetic BMI score was associated with variables related to poor physical health (R2 ranges from 0.02-0.10), metabolic syndrome (R2 ranges from 0.01-0.09), lower crystallised intelligence (R2=0.01), lower health-related quality of life (R2=0.02), physical inactivity (R2=0.02), and social deprivation (R2=0.02). The epigenetic BMI score (per SD) was also associated with self-reported type 2 diabetes (OR 2.25, 95 % CI 1.74, 2.94), cardiovascular disease (OR 1.44, 95 % CI 1.23, 1.69) and high blood pressure (OR 1.21, 95% CI 1.13, 1.48; all at p<0.0011 after Bonferroni correction).ConclusionsOur results show that regression models with epigenetic and phenotypic BMI scores as predictors account for a greater proportion of all outcome variables than either predictor alone, demonstrating independent and additive effects of epigenetic and phenotypic BMI scores.

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

International Journal of Obesity ◽

10.1038/s41366-018-0262-3 ◽

2019 ◽

Vol 43 (9) ◽

pp. 1795-1802 ◽

Cited By ~ 3

Author(s):

Olivia K. L. Hamilton ◽

Qian Zhang ◽

Allan F. McRae ◽

Rosie M. Walker ◽

Stewart W. Morris ◽

...

Keyword(s):

Dna Methylation ◽

Physical Health ◽

Birth Cohort ◽

Poor Physical Health ◽

Major Disease ◽

Lothian Birth Cohort

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Differences in exercise capacity and health-related quality of life according to the body mass index in patients with COPD

Pulmonology ◽

10.1016/j.pulmoe.2021.07.002 ◽

2021 ◽

Author(s):

Jhonatan Betancourt-Peña ◽

Juan Carlos Ávila-Valencia ◽

Diana Milena Diaz-Vidal ◽

Vicente Benavides-Córdoba

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Exercise Capacity ◽

Body Mass ◽

The Body ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

Translational Psychiatry ◽

10.1038/s41398-019-0576-5 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 5

Author(s):

Janie Corley ◽

Simon R. Cox ◽

Sarah E. Harris ◽

Maria Valdéz Hernandez ◽

Susana Muñoz Maniega ◽

...

Keyword(s):

Dna Methylation ◽

Cognitive Function ◽

Health Outcomes ◽

Physical Health ◽

Birth Cohort ◽

Smoking Status ◽

Brain Mri ◽

Smoking Exposure ◽

Eta Squared ◽

Lothian Birth Cohort

Abstract Recent advances in genome-wide DNA methylation (DNAm) profiling for smoking behaviour have given rise to a new, molecular biomarker of smoking exposure. It is unclear whether a smoking-associated DNAm (epigenetic) score has predictive value for ageing-related health outcomes which is independent of contributions from self-reported (phenotypic) smoking measures. Blood DNA methylation levels were measured in 895 adults aged 70 years in the Lothian Birth Cohort 1936 (LBC1936) study using the Illumina 450K assay. A DNA methylation score based on 230 CpGs was used as a proxy for smoking exposure. Associations between smoking variables and health outcomes at age 70 were modelled using general linear modelling (ANCOVA) and logistic regression. Additional analyses of smoking with brain MRI measures at age 73 (n = 532) were performed. Smoking-DNAm scores were positively associated with self-reported smoking status (P < 0.001, eta-squared ɳ2 = 0.63) and smoking pack years (r = 0.69, P < 0.001). Higher smoking DNAm scores were associated with variables related to poorer cognitive function, structural brain integrity, physical health, and psychosocial health. Compared with phenotypic smoking, the methylation marker provided stronger associations with all of the cognitive function scores, especially visuospatial ability (P < 0.001, partial eta-squared ɳp2 = 0.022) and processing speed (P < 0.001, ɳp2 = 0.030); inflammatory markers (all P < 0.001, ranges from ɳp2 = 0.021 to 0.030); dietary patterns (healthy diet (P < 0.001, ɳp2 = 0.052) and traditional diet (P < 0.001, ɳp2 = 0.032); stroke (P = 0.006, OR 1.48, 95% CI 1.12, 1.96); mortality (P < 0.001, OR 1.59, 95% CI 1.42, 1.79), and at age 73; with MRI volumetric measures (all P < 0.001, ranges from ɳp2 = 0.030 to 0.052). Additionally, education was the most important life-course predictor of lifetime smoking tested. Our results suggest that a smoking-associated methylation biomarker typically explains a greater proportion of the variance in some smoking-related morbidities in older adults, than phenotypic measures of smoking exposure, with some of the accounted-for variance being independent of phenotypic smoking status.

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The assessment of health-related quality of life in relation to the body mass index value in the urban population of Belgrade

Health and Quality of Life Outcomes ◽

10.1186/1477-7525-6-106 ◽

2008 ◽

Vol 6 (1) ◽

pp. 106 ◽

Cited By ~ 26

Author(s):

Nadja Vasiljevic ◽

Sonja Ralevic ◽

Jelena Marinkovic ◽

Nikola Kocev ◽

Milos Maksimovic ◽

...

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Body Mass ◽

Urban Population ◽

The Body ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Index Value

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Negative Effects of Pretransplant Body Mass Index on Physical Health—Related Quality of Life after Lung Transplant

Progress in Transplantation ◽

10.7182/pit2012582 ◽

2012 ◽

Vol 22 (4) ◽

pp. 363-368 ◽

Cited By ~ 4

Author(s):

Haley M. Hoy ◽

Irene D. Feurer ◽

Susan Alexander ◽

Jim Loyd ◽

Nancy Wells ◽

...

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Physical Health ◽

Body Mass ◽

Lung Transplant ◽

Health Related Quality ◽

Negative Effects ◽

Related Quality ◽

Health Related

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Childhood and Maternal Effects on Physical Health Related Quality of Life Five Decades Later: The British 1946 Birth Cohort

PLoS ONE ◽

10.1371/journal.pone.0088524 ◽

2014 ◽

Vol 9 (3) ◽

pp. e88524 ◽

Cited By ~ 9

Author(s):

Gita D. Mishra ◽

Stephanie Black ◽

Mai Stafford ◽

Rachel Cooper ◽

Diana Kuh ◽

...

Keyword(s):

Quality Of Life ◽

Physical Health ◽

Birth Cohort ◽

Maternal Effects ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Predictors of Health-Related Quality of Life in Outpatients with Cirrhosis: Results from a Prospective Cohort

Hepatitis Research and Treatment ◽

10.1155/2013/479639 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 5

Author(s):

Maja Thiele ◽

Gro Askgaard ◽

Hans B. Timm ◽

Ole Hamberg ◽

Lise L. Gluud

Keyword(s):

Quality Of Life ◽

Body Mass Index ◽

Body Mass ◽

The Body ◽

Poor Hrqol ◽

Related Quality ◽

Health Related ◽

Chronic Liver Disease Questionnaire ◽

Disease Questionnaire

Background. Cirrhosis may lead to a poor health-related quality of life (HRQOL), which should be taken into consideration when addressing the cirrhotic outpatient. Methods. Prospective cohort study evaluating predictors of HRQOL in outpatients with cirrhosis. Patients with overt hepatic encephalopathy at baseline were excluded. HRQOL was evaluated at baseline using the six point Chronic Liver Disease Questionnaire. Predictors of low quality of life scores (<4 points) and mortality were analyzed using multivariable logistic regression. Results. In total, 92 patients were included (mean age 61 years, 59% male). Nineteen patients died (mean duration of follow-up 20 months). The mean Child-Pugh score was 6.9. Twenty percent had a poor HRQOL judged by the Chronic Liver Disease Questionnaire score and 45% had covert hepatic encephalopathy. The only predictors of poor HRQOL were the Child-Pugh score (β=0.45;P=0.013), nonalcoholic etiology of cirrhosis (β=−2.34;P=0.009), and body mass index (β=−0.20;P=0.023). The body mass index predicted poor HRQOL independently of the presence of ascites and albumin level. Conclusions. The body mass index was associated with a low HRQOL. This suggests that malnutrition may be an important target in the management of patients with cirrhosis.

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Psychological Distress and Social Integration of Elderly People With Physical Disabilities

Function and Disability Journal ◽

10.32598/fdj.4.32 ◽

2021 ◽

Vol 4 (1) ◽

pp. 32-32

Author(s):

Mohammad Taghi Karimian ◽

◽

Sonja Düllmann ◽

Wolfgang Senf ◽

Sefik Tagay ◽

...

Keyword(s):

Quality Of Life ◽

Physical Health ◽

Social Integration ◽

Physical Disabilities ◽

Health Related Quality ◽

Poor Physical Health ◽

Related Quality ◽

Health Related ◽

People With Physical Disabilities

Background and Objectives: Poor physical health can affect the performance of everyday life activities and integration into society. The extent of disability or its influence on the life of an individual is related to his/her physical and social environment. This study aimed to examine the psychological existential orientation and social integration of elders with physical disabilities. Methods: Forty-six people with physical disabilities (with Mean±SD age of 73.7±10.6 years and age range of 53-93 years) were examined regarding psychological existential orientation, social integration, and health-related quality of life, using an extensive questionnaire set, including questionnaire on assistive technology, the Brief Symptom Inventory, and health-related quality of life. Results: The results showed that poor physical health can negatively impact the psyche and integration of the sample into society. Also, the subjects indicated a strong desire for more integration into society, however, they did not significantly participate in society in the last two weeks. Conclusion: Poor health and dependence on the environment in daily life can negatively influence the psychological and social situation and also limit social integration.

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Self-reported symptoms of arm lymphedema and health-related quality of life among female breast cancer survivors

Scientific Reports ◽

10.1038/s41598-021-89055-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Kayo Togawa ◽

Huiyan Ma ◽

Ashley Wilder Smith ◽

Marian L. Neuhouser ◽

Stephanie M. George ◽

...

Keyword(s):

Breast Cancer ◽

Quality Of Life ◽

Physical Health ◽

Analysis Of Covariance ◽

Health Related Quality ◽

Burning Pain ◽

Related Quality ◽

Health Related ◽

Arm Lymphedema

AbstractWe examined cross-sectional associations between arm lymphedema symptoms and health-related quality of life (HRQoL) in the Health, Eating, Activity and Lifestyle (HEAL) Study. 499 women diagnosed with localized or regional breast cancer at ages 35–64 years completed a survey, on average 40 months after diagnosis, querying presence of lymphedema, nine lymphedema-related symptoms, e.g., tension, burning pain, mobility loss, and warmth/redness, and HRQoL. Analysis of covariance models were used to assess HRQoL scores in relation to presence of lymphedema and lymphedema-related symptoms. Lymphedema was self-reported by 137 women, of whom 98 were experiencing lymphedema at the time of the assessment. The most common symptoms were heaviness (52%), numbness (47%), and tightness (45%). Perceived physical health was worse for women reporting past or current lymphedema than those reporting no lymphedema (P-value < 0.0001). No difference was observed for perceived mental health (P-value = 0.31). Perceived physical health, stress, and lymphedema-specific HRQoL scores worsened as number of symptoms increased (P-values ≤ 0.01). Women reporting tension in the arm had lower physical health (P-value = 0.01), and those experiencing burning pain, tension, heaviness, or warmth/redness in the arm had lower lymphedema-specific HRQoL (P-values < 0.05). Treatment targeting specific lymphedema-related symptoms in addition to size/volume reduction may improve some aspects of HRQoL among affected women.

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