A double-edged sword: supramolecular complexes of triazavirine display multicenter binding effects which influence aggregate formation
Keyword(s):
Triazavirine (TZV), a small molecule with a broad spectrum of antiviral activity, shows a tendency to induce the aggregation of melittin (MLT), a cationic membrane-disrupting peptide from the poison of the European bee. In MLT:TZV mixtures, high molecular weight precipitates form once a critical MLT:TZV ratio has been exceeded. Molecular dynamics simulation of MLT-TZV interactions, followed by molecular docking, led us to the hypothesis of multicenter binding of TZV supramolecular complexes to MLT.
2020 ◽
pp. 1-14
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2018 ◽
Vol 160
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pp. 397-403
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2017 ◽
Vol 20
(8)
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2019 ◽
Vol 120
(10)
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pp. 17015-17029
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2019 ◽
Vol 219
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pp. 83-90
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Keyword(s):
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