scholarly journals Architecture and organization of mouse posterior parietal cortex relative to extrastriate areas

2018 ◽  
Author(s):  
Karoline Hovde ◽  
Michele Gianatti ◽  
Menno P. Witter ◽  
Jonathan R. Whitlock
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Muscarinic Acetylcholine Receptor ◽  
Thalamic Nuclei ◽  
Cortical Connections ◽  
Posterior Parietal ◽  
Definition Of ◽  
Anterograde Tracer ◽  
Higher Visual Areas ◽  
Extrastriate Areas

ABSTRACTThe posterior parietal cortex (PPC) is a multifaceted region of cortex, contributing to several cognitive processes including sensorimotor integration and spatial navigation. Although recent years have seen a considerable rise in the use of rodents, particularly mice, to investigate PPC and related networks, a coherent anatomical definition of PPC in the mouse is still lacking. To address this, we delineated the mouse PPC using cyto- and chemoarchitectural markers from Nissl-, parvalbumin- and muscarinic acetylcholine receptor M2-staining. Additionally, we performed bilateral triple anterograde tracer injections in primary visual cortex (V1) and prepared flattened tangential sections from one hemisphere and coronal sections from the other, allowing us to co-register the cytoarchitectural features of PPC with V1 projections. In charting the location of extrastriate areas and the architectural features of PPC in the context of each other, we reconcile different, widely used conventions for demarcating PPC in the mouse. Furthermore, triple anterograde tracer injections in PPC showed strong projections to associative thalamic nuclei as well as higher visual areas, orbitofrontal, cingulate and secondary motor cortices. Retrograde circuit mapping with rabies virus further showed that all cortical connections were reciprocal. These combined approaches provide a coherent definition of mouse PPC that incorporates laminar architecture, extrastriate projections, thalamic, and cortico-cortical connections.

scholarly journals Reconsidering the Border between the Visual and Posterior Parietal Cortex of Mice

2020 ◽  
Author(s):  
Sara R J Gilissen ◽  
Karl Farrow ◽  
Vincent Bonin ◽  
Lutgarde Arckens
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Spatial Navigation ◽  
Thalamic Nuclei ◽  
Anterior Cortex ◽  
Detailed Understanding ◽  
Cortical Input ◽  
Visual Areas ◽  
Posterior Parietal ◽  
Cortical Map

Abstract The posterior parietal cortex (PPC) contributes to multisensory and sensory-motor integration, as well as spatial navigation. Based on primate studies, the PPC is composed of several subdivisions with differing connection patterns, including areas that exhibit retinotopy. In mice the composition of the PPC is still under debate. We propose a revised anatomical delineation in which we classify the higher order visual areas rostrolateral area (RL), anteromedial area (AM), and Medio-Medial-Anterior cortex (MMA) as subregions of the mouse PPC. Retrograde and anterograde tracing revealed connectivity, characteristic for primate PPC, with sensory, retrosplenial, orbitofrontal, cingulate and motor cortex, as well as with several thalamic nuclei and the superior colliculus in the mouse. Regarding cortical input, RL receives major input from the somatosensory barrel field, while AM receives more input from the trunk, whereas MMA receives strong inputs from retrosplenial, cingulate, and orbitofrontal cortices. These input differences suggest that each posterior PPC subregion may have a distinct function. Summarized, we put forward a refined cortical map, including a mouse PPC that contains at least 6 subregions, RL, AM, MMA and PtP, MPta, LPta/A. These anatomical results set the stage for a more detailed understanding about the role that the PPC and its subdivisions play in multisensory integration-based behavior in mice.

scholarly journals Cortical Connections of the Caudal Portion of Posterior Parietal Cortex in Prosimian Galagos

2015 ◽  
Vol 26 (6) ◽  
pp. 2753-2777 ◽  
Author(s):  
Iwona Stepniewska ◽  
Christina M. Cerkevich ◽  
Jon H. Kaas
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Cortical Connections ◽  
Caudal Portion ◽  
Posterior Parietal

scholarly journals Dissociating the contributions of human frontal eye fields and posterior parietal cortex to visual search

2011 ◽  
Vol 105 (6) ◽  
pp. 2891-2896 ◽  
Author(s):  
Neil G. Muggleton ◽  
Roger Kalla ◽  
Chi-Hung Juan ◽  
V. Walsh
Keyword(s):  
Visual Search ◽  
Parietal Cortex ◽  
Visual Information ◽  
Posterior Parietal Cortex ◽  
Frontal Eye Fields ◽  
Search Performance ◽  
Manual Response ◽  
Visual Processes ◽  
Posterior Parietal ◽  
Extrastriate Areas

Imaging, lesion, and transcranial magnetic stimulation (TMS) studies have implicated a number of regions of the brain in searching for a target defined by a combination of attributes. The necessity of both frontal eye fields (FEF) and posterior parietal cortex (PPC) in task performance has been shown by the application of TMS over these regions. The effects of stimulation over these two areas have, thus far, proved to be remarkably similar and the only dissociation reported being in the timing of their involvement. We tested the hypotheses that 1) FEF contributes to performance in terms of visual target detection (possibly by modulation of activity in extrastriate areas with respect to the target), and 2) PPC is involved in translation of visual information for action. We used a task where the presence (and location) of the target was indicated by an eye movement. Task disruption was seen with FEF TMS (with reduced accuracy on the task) but not with PPC stimulation. When a search task requiring a manual response was presented, disruption with PPC TMS was seen. These results show dissociation of FEF and PPC contributions to visual search performance and that PPC involvement seems to be dependent on the response required by the task, whereas this is not the case for FEF. This supports the idea of FEF involvement in visual processes in a manner that might not depend on the required response, whereas PPC seems to be involved when a manual motor response to a stimulus is required.

Posterior parietal cortex projections to the ventral lateral and some association thalamic nuclei in Macaca mulatta

2002 ◽  
Vol 59 (2) ◽  
pp. 135-150 ◽  
Author(s):  
Otar Taktakishvili ◽  
Elena Sivan-Loukianova ◽  
Kristy Kultas-Ilinsky ◽  
Igor A Ilinsky
Keyword(s):  
Parietal Cortex ◽  
Macaca Mulatta ◽  
Posterior Parietal Cortex ◽  
Thalamic Nuclei ◽  
Posterior Parietal

scholarly journals Reconsidering the border between the visual and posterior parietal cortex of mice

2020 ◽  
Author(s):  
Sara R. J. Gilissen ◽  
Karl Farrow ◽  
Vincent Bonin ◽  
Lutgarde Arckens
Keyword(s):  
Parietal Cortex ◽  
Posterior Parietal Cortex ◽  
Higher Order ◽  
Anatomical Location ◽  
List Type ◽  
Thalamic Nuclei ◽  
Cortical Input ◽  
Mouse Cortex ◽  
Visual Areas ◽  
Posterior Parietal

AbstractThe posterior parietal cortex (PPC) contributes to multisensory and sensory-motor integration, as well as spatial navigation. Based on studies in primates, the PPC is composed of several subdivisions with differing connection patterns, including areas that exhibit retinotopy. In mice the exact anatomical location and composition of the PPC is poorly understood. We present a revised delineation in which we classify the higher-order visual areas RL, AM and MMA as subregions of the mouse PPC. Retrograde and anterograde tracing revealed connectivity, characteristic for primate PPC, with sensory, retrosplenial, orbitofrontal, cingulate and motor cortex, as well as with several thalamic nuclei and the superior colliculus in the mouse. Regarding cortical input, RL receives major input from the somatosensory barrel field, while AM receives more input from the trunk, whereas MMA receives strong inputs from retrosplenial, cingulate and orbitofrontal cortices. These input differences suggest that each new PPC sub-region has a distinct function. Summarized, we put forward a new refined cortical map, including a mouse PPC that contains at least 6 sub-regions, RL, AM, MMA and PtP, MPta, LPta/A. These results will facilitate a more detailed understanding about the role that the PPC and its subdivisions play in multisensory integration-based behavior in mice.HighlightsHigher-order visual areas RL, AM and MMA are part of the posterior parietal cortex (PPC) of the mouse based on connectivity.The mouse PPC contains at least 6 sub-regions, including RL, AM, MMA, PtP, LPtA/A and MPtASpecialized cortical input patterns to the new PPC subdivisions may reflect division of function.A new flattened map for mouse cortex represents refined auditory, visual, retrosplenial and PPC areas.

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