scholarly journals Optimization of swelling response of pH sensitive hydrogels using Box-Behnken design

2018 ◽  
Author(s):  
Fereshteh Shokri ◽  
Pouneh Ebrahimi ◽  
Soheyla Honary
Keyword(s):  
Polymer Networks ◽  
Three Dimensional ◽  
Statistical Design ◽  
Ph Sensitive ◽  
Vinyl Pyrrolidone ◽  
Swelling Properties ◽  
Screening Design ◽  
Statistical Screening ◽  
Poly Vinyl Pyrrolidone ◽  
Responsive Hydrogels

AbstractHydrogels are three-dimensional crosslinked hydrophilic polymer networks capable of swelling or de-swelling reversibly in water and retaining a large volume of liquid in swollen state. Hydrogels can be designed with controllable responses to shrink or expand with changes in external environmental conditions. Among stimulisensitive hydrogels, the pH-sensitive ones are widely-studied and used. Despite these advances, we currently lack a systematic way to optimize the synthesis protocols. Here we propose to use techniques from chemometrics, namely Box–Behnken statistical screening design to optimize the chemical composition of pH-responsive hydrogels for an improved responsiveness as quantified by swelling index. Polymer blends were prepared by mixing different suitable volume of pvp (poly vinyl pyrrolidone) and chitosan aqueous solution in order to obtain a mixture, glutardialdehyde solution was added as crosslinkers to the chitosan/pvp mixture to form semi-IPN(semi-interpenetrating polymeric hydrogel). The pH-dependent swelling properties have been measured and used to obtain a regression model. We characterized the descriptive and predictive abilities of our model. We found a remarkable correlation (correlation coefficient = 0.954) between the observed responses and the responses predicted by the model. Our results demonstrate that Box-Behnken is an appropriate statistical design that can be successfully used in the development of pH-sensitive hydrogels with a predictable swelling ratio. This technology will remarkably reduce the time and cost that is needed for chemical synthesis of hydrogels with a desired pH-sensitivity.

scholarly journals Fabrication Of Glimepiride Datura Stramonium Leaves Mucilage And Poly Vinyl Pyrrolidone Sustained Release Matrix Tablets: In Vitro Evaluation

1970 ◽  
Vol 8 (1) ◽  
pp. 63-72
Author(s):  
Abdul Ahad Hindustan ◽  
U Anand Babu ◽  
K Nagesh ◽  
D Sai Kiran ◽  
K Bindu Madhavi
Keyword(s):  
Mechanical Properties ◽  
Sustained Release ◽  
Datura Stramonium ◽  
Matrix Tablets ◽  
Vinyl Pyrrolidone ◽  
Stability Studies ◽  
Swelling Properties ◽  
Accelerated Stability ◽  
Poly Vinyl Pyrrolidone

The main purpose of the present work was to develop matrix tablets of Glimepiride with Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Mucilage from Datura stramonium leaves was extracted, isolated, purified and characterized. Physicochemical properties of the dried powdered mucilage of Datura stramonium leaves were studied. Various formulations of Glimepiride Datura stramonium leave mucilage and Poly Vinyl Pyrrolidone were prepared. The formulated tablets were tested for mechanical properties, friability, swelling behavior, in vitro drug release pattern and the dissolution data was treated with mathematical modeling and the optimized formulation was tested for accelerated stability studies. The formulated tablets were found to have good mechanical properties, good swelling properties. The in vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. From this study it was concluded that the dried Datura stramonium leaves mucilage and Poly Vinyl Pyrrolidone combination can be used as a matrix forming material for making sustained release matrix tablets. DOI: http://dx.doi.org/10.3126/kuset.v8i1.6044 KUSET 2012; 8(1): 63-72

Gradient semi-interpenetrating polymer networks based on polyurethane and poly(vinyl pyrrolidone)

2005 ◽  
Vol 15 (4) ◽  
pp. 499 ◽  
Author(s):  
Lyudmila V. Karabanova ◽  
Sergey V. Mikhalovsky ◽  
Andrew W. Lloyd ◽  
Gisele Boiteux ◽  
Lyudmila M. Sergeeva ◽  
...  
Keyword(s):  
Polymer Networks ◽  
Interpenetrating Polymer Networks ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Pyrrolidone

scholarly journals The influence of KrF excimer laser irradiation on the surface of collagen and collagen/PVP films

2006 ◽  
Vol 2006 ◽  
pp. 1-7 ◽  
Author(s):  
M. Wisniewski ◽  
A. Sionkowska ◽  
H. Kaczmarek ◽  
J. Skopinska ◽  
S. Lazare ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Excimer Laser ◽  
Bubble Formation ◽  
Three Dimensional ◽  
Single Pulse ◽  
Local Heat ◽  
Vinyl Pyrrolidone ◽  
Excimer Laser Irradiation ◽  
Krf Excimer Laser ◽  
Poly Vinyl Pyrrolidone

The surface properties of collagen and collagen/poly(vinyl pyrrolidone) (PVP) films after KrF excimer laser irradiation (λ=248nm) were investigated by means of the technique of scanning electron microscopy (SEM) and optical microscopy (OM). The laser irradiation of the used specimens caused an expansion of materials above their surface with pronounced sings of its melting. The height of the ablated volume in a case of collagen film at a fluence of1.1J/cm2was approximately 5μm. A white damage appears on the treated surfaces at a threshold of0.5J/cm2with a single pulse and becomes more visible for a higher fluence. It is also noteworthy that along with increasing fluences (beginning from the fluence of1.7J/cm2), the characteristic filaments at the spot edges are observed. The local heat and pressure generated by the laser radiation were able to induce bubble formation on the surface. Further bubble colliding and bursting produce a three-dimensional polymer “microfoam” structure with interconnected pores. These results can be of interest for some new applications.

scholarly journals ALD coating of centrifugally spun polymeric fibers and postannealing: case study for nanotubular TiO2 photocatalyst

2021 ◽  
Author(s):  
Martina Rihova ◽  
Oksana Yurkevich ◽  
Martin Motola ◽  
Ludek Hromadko ◽  
Zdeněk Spotz ◽  
...  
Keyword(s):  
Atomic Layer Deposition ◽  
Atomic Layer ◽  
Vinyl Pyrrolidone ◽  
Tio2 Photocatalyst ◽  
Polymeric Fibers ◽  
Layer Deposition ◽  
Centrifugal Spinning ◽  
Poly Vinyl Pyrrolidone

This work describes the synthesis of highly photocatalytically active TiO2 tubes (TiTBs) by combining centrifugal spinning and atomic layer deposition (ALD). Poly(vinyl pyrrolidone) (PVP) fibers were first produced by centrifugal...

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