scholarly journals Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography

2019 ◽  
Author(s):  
Son Ta Dinh ◽  
Moritz M. Nickel ◽  
Laura Tiemann ◽  
Elisabeth S. May ◽  
Henrik Heitmann ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Resting State ◽  
Brain Activity ◽  
Control Group ◽  
Brain Areas ◽  
Frontal Brain ◽  
Disease Markers ◽  
Chronic Pain Patients ◽  
Gamma Frequencies ◽  
Pain Patients

AbstractChronic pain is a common and severely disabling disease whose treatment is often unsatisfactory. Insights into the brain mechanisms of chronic pain promise to advance the understanding of the underlying pathophysiology and might help to develop disease markers and novel treatments. Here, we systematically and comprehensively exploited the potential of electroencephalography (EEG) to determine abnormalities of brain function during the resting state in chronic pain. To this end, we performed state-of-the-art analyses of oscillatory brain activity, brain connectivity and brain networks in 101 patients of either sex suffering from chronic pain. The results show that global and local measures of brain activity did not differ between chronic pain patients and a healthy control group. However, we observed significantly increased connectivity at theta (4 – 8 Hz) and gamma (> 60 Hz) frequencies in frontal brain areas as well as global network reorganization at gamma frequencies in chronic pain patients. Furthermore, a machine learning algorithm could differentiate between patients and healthy controls with an above-chance accuracy of 57%, mostly based on frontal connectivity. These results implicate increased theta and gamma synchrony in frontal brain areas in the pathophysiology of chronic pain. While substantial challenges concerning accuracy, specificity and validity of potential EEG-based disease markers remain to be overcome, our study identifies abnormal frontal synchrony at theta and gamma frequencies as promising targets for non-invasive brain stimulation and/or neurofeedback approaches.

scholarly journals Emotional and Neurobehavioural Status in Chronic Pain Patients

2011 ◽  
Vol 16 (1) ◽  
pp. 41-43 ◽  
Author(s):  
He Shuchang ◽  
He Mingwei ◽  
Jia Hongxiao ◽  
Wu Si ◽  
Yang Xing ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Back Pain ◽  
Lower Back Pain ◽  
Mood State ◽  
Control Group ◽  
Chronic Lower Back Pain ◽  
Control Subjects ◽  
Lower Back ◽  
Chronic Pain Patients ◽  
Pain Patients

OBJECTIVE: To investigate the emotional and neurobehavioural status of patients suffering from chronic pain.METHODS: Fifteen male patients with chronic lower back pain and 15 healthy control subjects were studied for approximately six months. Pain was measured using a visual analogue scale. The WHO Neurobehavioral Core Test Battery (NCTB) was used to assess neurobehavioural effects of environmental and occupational exposures.RESULTS: Visual analogue scale results demonstrated a modest range of reported pain (mean [± SD] 62.0±10.8) in chronic pain patients, whereas control subjects reported no measurable pain. With the NCTB, it was found that scores of negative mood state, including anger-hostility, depression-dejection, fatigue-inertia and tension-anxiety in pain patients were significantly higher than scores in the control subjects. By contrast, scores of positive mood state (vigour-activity) in chronic pain patients were lower than those in the control group. The NCTB scores of the Santa Ana Dexterity and Pursuit Aiming II tests in chronic lower back pain patients were lower than those of the control group. Scores for other NCTB sub-tests, including the Digit Span, Benton Visual Retention and Digit Symbol tests, were not significantly different compared with controls.CONCLUSIONS: Chronic lower back pain patients had more negative mood and less positive mood than controls. These patients also demonstrated neuromotor deficits in coordination and reaction time. Further studies are required to examine possible neurological mechanisms and research potential intervention strategies for patients suffering from chronic pain.

Longitudinal resting-state electroencephalography in chronic pain patients undergoing interdisciplinary multimodal pain therapy

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Henrik Heitmann ◽  
Cristina Gil Ávila ◽  
Moritz M. Nickel ◽  
Son Ta Dinh ◽  
Elisabeth S. May ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Resting State ◽  
Pain Therapy ◽  
Multimodal Pain Therapy ◽  
Chronic Pain Patients ◽  
Interdisciplinary Multimodal Pain Therapy ◽  
Pain Patients

scholarly journals 2135

2017 ◽  
Vol 1 (S1) ◽  
pp. 69-69
Author(s):  
Kathryn E. Kanzler ◽  
Patricia Robinson ◽  
Mariana Munante ◽  
Donald McGeary ◽  
Jennifer Potter ◽  
...  
Keyword(s):  
Primary Care ◽  
Chronic Pain ◽  
Behavioral Health ◽  
Control Group ◽  
Health Provider ◽  
Care Clinic ◽  
Integrated Behavioral Health ◽  
Behavioral Health Provider ◽  
Chronic Pain Patients ◽  
Pain Patients

OBJECTIVES/SPECIFIC AIMS: This study seeks to test the feasibility and effectiveness of a brief acceptance and commitment therapy (ACT) treatment for chronic pain patients in a primary care clinic METHODS/STUDY POPULATION: Primary care patients aged 18 years and older with at least 1 pain condition for 12 weeks or more in duration will be recruited. Patients will be randomized into (a) ACT intervention or (b) control group. Participants in the ACT arm will attend 1 individual visit with an integrated behavioral health provider, followed by 3 weekly ACT classes and a booster class 2 months later. Control group will receive enhanced primary care that includes patient education handouts informed by cognitive behavioral science. Data analysis will include 1-way analysis of covariance (ANCOVA), multiple regression with bootstrapping. RESULTS/ANTICIPATED RESULTS: The overall hypothesis is that brief ACT treatment reduces physical disability, improves functioning, and reduces medication misuse in chronic pain patients when delivered by an integrated behavioral health provider in primary care. In addition, it is anticipated that improvements in patient functioning will be mediated by patient change in pain acceptance and patient engagement in value-consistent behaviors. DISCUSSION/SIGNIFICANCE OF IMPACT: This pilot study will establish preliminary data about the effectiveness of addressing chronic pain in a generalizable integrated primary care setting. Data will help support a larger trial in the future. Findings have potential to transform the way chronic pain is currently managed in primary care settings, with results that could decrease disability and improve functioning among patients suffering from chronic pain.

scholarly journals Dynamics of brain function in chronic pain patients assessed by microstate analysis of resting-state electroencephalography

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Elisabeth S. May ◽  
Cristina Gil Ávila ◽  
Son Ta Dinh ◽  
Henrik Heitmann ◽  
Vanessa D. Hohn ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Resting State ◽  
Brain Function ◽  
Chronic Pain Patients ◽  
Microstate Analysis ◽  
Pain Patients

scholarly journals A Randomized, Controlled Trial of Wholistic Hybrid Derived From Eye Movement Desensitization and Reprocessing and Emotional Freedom Technique (WHEE) for Self-Treatment of Pain, Depression, and Anxiety in Chronic Pain Patients

2016 ◽  
Vol 22 (2) ◽  
pp. 268-277 ◽  
Author(s):  
Daniel Benor ◽  
John Rossiter-Thornton ◽  
Loren Toussaint
Keyword(s):  
Chronic Pain ◽  
Pilot Study ◽  
Incidental Finding ◽  
Controlled Trial ◽  
Psychological Trauma ◽  
Control Group ◽  
Wait List ◽  
Convenience Sample ◽  
Chronic Pain Patients ◽  
Pain Patients

In this pilot study, a convenience sample of 24 chronic pain patients (17 with chronic fatigue syndrome/fibromyalgia) were randomized into WHEE treatment and wait-list control groups for 6 weeks. Assessments of depression, anxiety, and pain were completed before, during, and at 1 and 3 months after treatment. Wait-listed patients then received an identical course of WHEE and assessments. WHEE decreased anxiety ( P < .5) and depression ( P < .05) compared with the control group. The wait-list-turned-WHEE assessments demonstrated decreased pain severity ( P < .05) and depression ( P < .04) but not pain interference or anxiety. WHEE appears a promising method for pain, anxiety, and depression in patients with chronic pain, compared to standard medical care alone. Though a small pilot study, the present results suggest that further research appears warranted. An incidental finding was that a majority of patients with chronic pain had suffered psychological trauma in childhood and/or adulthood.

scholarly journals Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography

Pain ◽  
2019 ◽  
Vol 160 (12) ◽  
pp. 2751-2765 ◽  
Author(s):  
Son Ta Dinh ◽  
Moritz M. Nickel ◽  
Laura Tiemann ◽  
Elisabeth S. May ◽  
Henrik Heitmann ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Resting State ◽  
Brain Dysfunction ◽  
Chronic Pain Patients ◽  
Pain Patients

scholarly journals Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Susanne Becker ◽  
Edita Navratilova ◽  
Frauke Nees ◽  
Stefaan Van Damme
Keyword(s):  
Chronic Pain ◽  
Brain Activity ◽  
Pain Processing ◽  
Cellular Mechanisms ◽  
Related Information ◽  
Current State ◽  
Chronic Pain Patients ◽  
Fear And Anxiety ◽  
Chronic Pain Conditions ◽  
Pain Patients

Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies.

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