scholarly journals Selective modulation of the glucocorticoid receptor with CORT108297 during chronic adolescent stress evokes sex-specific effects in adulthood

2019 ◽  
Author(s):  
Evelin Cotella ◽  
Rachel Morano ◽  
Aynara Wulsin ◽  
Susan Martelle ◽  
Paige Lemen ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Chronic Stress ◽  
Emotional Reactivity ◽  
Forced Swim Test ◽  
Emotional Behavior ◽  
Female Rats ◽  
Passive Coping ◽  
Swim Test ◽  
Adolescent Stress ◽  
Male And Female Rats

AbstractAdolescent animals are vulnerable to the effects of stress on brain development. We hypothesized that long-term effects of adolescent chronic stress are mediated by glucocorticoid receptor (GR) signaling. We used a specific GR modulator (CORT108297) to pharmacologically disrupt GR signaling in adolescent rats during exposure chronic variable stress (CVS). Male and female rats received 30mg/kg of drug concomitantly with a 2-week CVS protocol starting at PND46. Emotional reactivity (open field) and coping behaviors (forced swim test (FST)) were then tested in adulthood, 5 weeks after the end of the CVS protocol. Blood samples were collected two days before FST and serial samples after the onset of the swim test to determine baseline and stress response levels of HPA hormones respectively.Our results support differential behavioral, physiological and stress circuit reactivity to adolescent chronic stress exposure in males vs. females, with variable involvement of GR signaling. In response to adolescent stress, males had heightened reactivity to novelty and exhibited marked reduction in neuronal excitation following swim stress in adulthood, whereas females developed a passive coping strategy and enhanced HPA axis stress reactivity. Only the latter effect was attenuated by treatment with the GR modulator C108297. Our data suggest that adolescent stress differentially affects emotional behavior and circuit development in females, and that GR plays a role in driving some but not all sequelae of adolescent stress.

scholarly journals Does the antidepressant-like effect of mirtazapine and venlafaxine differ between male and female rats?

Salud Mental ◽  
2020 ◽  
Vol 43 (1) ◽  
pp. 3-9
Author(s):  
Adriana Álvarez Silva ◽  
Alonso Fernández-Guasti
Keyword(s):  
Forced Swim Test ◽  
Treatment Options ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Swim Test ◽  
Male And Female Rats ◽  
Males And Females ◽  
New Treatment ◽  
Global Health Problem

Introduction. Depression is a global health problem with nearly 350 million people affected, mainly women. However, nowadays a rising amount of men are being diagnosed. This makes necessary the screening of new treatment options that are effective in women as well as in men. Objective. To analyze if the administration of mirtazapine and venlafaxine to male and female rats shows a sex-related antidepressant-like effect, and the possible associated neurochemical mechanisms. Method. Mirtazapine (40 mg/kg) or venlafaxine (60 mg/kg) were administered subchronically to young adult male and female (ovariectomized and steroid-primed) rats, and their antidepressant-like effects were evaluated using the forced swim test (FST). The active behaviors, swimming and climbing, were also analyzed. Results. a) mirtazapine and venlafaxine reduced immobility in the FST in males and females; b) both antidepressants increased climbing and swimming in male rats; c) in female rats, mirtazapine and venlafaxine only increased swimming. Discussion and conclusion. In males, the effects of mirtazapine and venlafaxine seem to be produced by the activation of the serotonergic and noradrenergic systems. Conversely, estradiol might be modulating the mechanisms of action of both antidepressants in females producing only an increased swimming and suggesting the participation of the serotonergic system.

Stressors affect the response of male and female rats to clomipramine in a model of behavioral despair (forced swim test)

2005 ◽  
Vol 520 (1-3) ◽  
pp. 100-107 ◽  
Author(s):  
Daniele Consoli ◽  
Julia Fedotova ◽  
Vincenzo Micale ◽  
Nikolay S. Sapronov ◽  
Filippo Drago
Keyword(s):  
Forced Swim Test ◽  
Female Rats ◽  
Male And Female ◽  
Behavioral Despair ◽  
Swim Test ◽  
Forced Swim ◽  
Male And Female Rats

scholarly journals Lasting Impact of Chronic Adolescent Stress and Glucocorticoid Receptor Selective Modulation in Male and Female Rats

2020 ◽  
Vol 112 ◽  
pp. 104490 ◽  
Author(s):  
Evelin M. Cotella ◽  
Rachel L. Morano ◽  
Aynara C. Wulsin ◽  
Susan M. Martelle ◽  
Paige Lemen ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Female Rats ◽  
Male And Female ◽  
Adolescent Stress ◽  
Male And Female Rats ◽  
Selective Modulation

scholarly journals Glucoregulation and coping behavior after chronic stress: sex differences across the lifespan

2021 ◽  
Author(s):  
Carley Dearing ◽  
Rachel Morano ◽  
Elaine Ptaskiewicz ◽  
Parinaz Mahbod ◽  
Jessie R Scheimann ◽  
...  
Keyword(s):  
Sex Differences ◽  
Chronic Stress ◽  
Life Stress ◽  
Forced Swim Test ◽  
Coping Behavior ◽  
Early Life Stress ◽  
Tolerance Test ◽  
Sprague Dawley ◽  
Late Adolescent ◽  
Passive Coping

AbstractExposure to prolonged stress during adolescence taxes adaptive and homeostatic processes leading to deleterious behavioral and metabolic outcomes. Although previous pre-clinical studies found effects of early life stress on cognition and stress hormone reactivity, these studies largely focused on males. The purpose of the current study was to determine how biological sex shapes behavioral coping and metabolic health across the lifespan after chronic stress. We hypothesized that examining chronic stress-induced behavioral and endocrine outcomes would reveal sex differences in the biological basis of susceptibility. During the late adolescent period, male and female Sprague-Dawley rats experienced chronic variable stress (CVS). Following completion of CVS, all rats experienced a forced swim test (FST) followed 3 days later by a fasted glucose tolerance test (GTT). The FST was used to determine coping in response to a stressor. Endocrine metabolic function was evaluated in the GTT by measuring glucose and corticosterone, the primary rodent glucocorticoid. Animals then aged to 15 months when the FST and GTT were repeated. In young animals, chronically stressed females exhibited more passive coping and corticosterone release in the FST. Additionally, chronically stressed females had elevated corticosterone and impaired glucose clearance in the GTT. Aging affected all measurements as behavioral and endocrine outcomes were sex specific. Furthermore, regression analysis between hormonal and behavioral responses identified associations depending on sex and stress. Collectively, these data indicate female susceptibility to the effects of chronic stress during adolescence. Further, translational investigation of coping style and glucose homeostasis may identify biomarkers for stress-related disorders.

scholarly journals Pair-housing of male and female rats during chronic stress exposure results in gender-specific behavioral responses

2005 ◽  
Vol 47 (5) ◽  
pp. 620-628 ◽  
Author(s):  
C. Westenbroek ◽  
T.A.B. Snijders ◽  
J.A. den Boer ◽  
M. Gerrits ◽  
D.S. Fokkema ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Behavioral Responses ◽  
Female Rats ◽  
Stress Exposure ◽  
Male And Female ◽  
Male And Female Rats ◽  
Gender Specific

Abstract # 3111 Chronic adolescent stress differentially sensitizes neuro-immune reactivity in male and female rats

2019 ◽  
Vol 76 ◽  
pp. e20
Author(s):  
M. Bekhbat ◽  
D. Mukhara ◽  
M.J. Dozmorov ◽  
J.C. Stansfield ◽  
S.D. Benusa ◽  
...  
Keyword(s):  
Female Rats ◽  
Immune Reactivity ◽  
Male And Female ◽  
Adolescent Stress ◽  
Male And Female Rats

Chronic Stress Effects on Sexual Behavior in Male and Female Rats

1998 ◽  
Vol 61 (4) ◽  
pp. 405-412 ◽  
Author(s):  
Boris B. Gorzalka ◽  
Laura A. Hanson ◽  
Lori A. Brotto
Keyword(s):  
Sexual Behavior ◽  
Chronic Stress ◽  
Female Rats ◽  
Male And Female ◽  
Stress Effects ◽  
Male And Female Rats
Sign in / Sign up

Export Citation Format

Share Document