scholarly journals Dorsal raphe oxytocin receptors regulate the neurobehavioral consequences of social touch

2019 ◽  
Author(s):  
Z.A. Grieb ◽  
E.G. Ford ◽  
F.P. Manfredsson ◽  
J.S. Lonstein
Keyword(s):  
Cortical Plasticity ◽  
Coping Behavior ◽  
Group Living ◽  
Dorsal Raphe ◽  
Social Touch ◽  
Oxytocin Receptors ◽  
Tactile Cues ◽  
Group Members ◽  
New Mother ◽  
Dorsal Raphé

SummaryProsocial interactions are essential for group-living animals and are regulated by tactile cues shared among the group members. Neurobiological mechanisms through which social touch influences prosociality and related affective behaviors are relatively unknown. Using the evolutionarily ancient mother-young dyad as a model, we hypothesized that neurobehavioral consequences of social touch involves an interaction between central oxytocin (released during social touch) and serotonin (regulating affect and neuroplasticity). New mother rats showed upregulation of numerous aspects of the oxytocin system in the midbrain dorsal raphe (DR; source of forebrain serotonin) compared to non-maternal females. Preventing this upregulation by OTR knockdown in the maternal DR elicited infanticide, reduced nursing, increased aggression, and decreased active coping behavior. OTR knockdown also decreased serotonin-immunoreactive fibers, and increased neuroplasticity-restricting perineuronal nets, in the primary somatosensory cortex. Thus, oxytocin signaling in the DR regulates mechanisms involved in serotonin-induced cortical plasticity, which refines the tactile processing underlying prosocial behaviors.

Oxytocin receptors in the midbrain dorsal raphe are essential for postpartum maternal social and affective behaviors

2021 ◽  
pp. 105332
Author(s):  
Zachary A. Grieb ◽  
Emma G. Ford ◽  
Mahircan Yagan ◽  
Billy Y.B. Lau ◽  
Fredric P. Manfredsson ◽  
...  
Keyword(s):  
Dorsal Raphe ◽  
Oxytocin Receptors ◽  
Affective Behaviors ◽  
Dorsal Raphé

Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats

2010 ◽  
Vol 473 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Ali Jahanshahi ◽  
Lee Wei Lim ◽  
Harry W.M. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
Yasin Temel
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Induced Changes ◽  
Dorsal Raphé

027 GABAergic Neurons in the Dorsal Raphe Nucleus Are under the Influence of GABAergic Inputs from the Nucleus Pontis Oralis

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A12-A12
Author(s):  
Jianhua Zhang ◽  
Mingchu Xi ◽  
Simon Fung ◽  
Charles Tobin ◽  
Sharon Sampogna ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Gabaergic Neurons ◽  
Fluorescent Labeling ◽  
Raphe Nucleus ◽  
Gaba A ◽  
Adult Cats ◽  
Immunohistochemical Techniques ◽  
Fluorescence Immunohistochemistry ◽  
Dorsal Raphé

Abstract Introduction Our previous study has shown that there is a direct connection between GABAergic neurons in the nucleus pontis oralis (NPO) and neurons of the dorsal raphe nucleus (DR), providing a morphological basis for the hypothesis that GABAergic inhibitory processes in NPO play an important role in the generation and maintenance of wakefulness as well as active (REM) sleep through the interaction with neurons in the DR. However, the target of such a GABAergic projection from the NPO within the DR is unknown. In the present study, a double-fluorescent labeling technique was employed to examine the target of GABAergic inputs to the DR. Methods Adult cats were deeply anesthetized and perfused transcardially. Subsequently, the brainstem containing the DR was removed, postfixed and cut into 15 μm coronal sections with a Reichert-Jung cryostat. The sections were immunostained with antibodies against GABA-A or GABA-B receptors and GABA following the procedure of double fluorescence immunohistochemistry. Results Under fluorescence microscopy, a large number of neurons were labeled with antibodies against either GABA-A receptor or GABA-B receptor. In addition, neurons labeled with antibody against GABA were observed in the DR. With double fluorescence immunohistochemical techniques, some neurons labeled by anti-GABA antibody were also stained with antibodies against GABA-A or GABA-B receptors. Conclusion The expression of GABA-A or GABA-B receptors by GABAergic neurons in the DR indicates that GABAergic neurons in the DR receive GABAergic inputs. Our previous study has demonstrated that these GABAergic inputs are from the NPO. These data provide a morphological foundation to support our hypothesis that, during wakefulness, NPO GABAergic “Executive” neurons suppress “Second-Order” GABAergic neurons in the DR, which, in turn, activate (disinhibit) serotonergic wake-on neurons in this nucleus. Support (if any) NS092383

scholarly journals Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aude Muzerelle ◽  
Mariano Soiza-Reilly ◽  
Cornelia Hainer ◽  
Pierre-Louis Ruet ◽  
Klaus-Peter Lesch ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Dorsal Raphe ◽  
Normal Mammary Gland ◽  
Knock Out ◽  
Maternal Experience ◽  
Pup Retrieval ◽  
Pup Survival ◽  
Gland Development ◽  
Severe Growth ◽  
Dorsal Raphé

AbstractProper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.

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