scholarly journals CRISPR Tools for Systematic Studies of RNA Regulation

2019 ◽  
Vol 11 (8) ◽  
pp. a035386 ◽  
Author(s):  
Jesse Engreitz ◽  
Omar Abudayyeh ◽  
Jonathan Gootenberg ◽  
Feng Zhang
Keyword(s):  
Rna Regulation

RNA Regulation by Estrogen

2011 ◽  
Author(s):  
J. A. Berglund ◽  
Rodger Voelker ◽  
Paul Barber ◽  
Julien Diegel ◽  
Amy Mahady ◽  
...  
Keyword(s):  
Rna Regulation

scholarly journals 6S RNA regulation of relA alters ppGpp levels in early stationary phase

Microbiology ◽  
2010 ◽  
Vol 156 (12) ◽  
pp. 3791-3800 ◽  
Author(s):  
Amy T. Cavanagh ◽  
Pete Chandrangsu ◽  
Karen M. Wassarman
Keyword(s):  
Amino Acid ◽  
Stationary Phase ◽  
Regulation Of Transcription ◽  
Early Stationary Phase ◽  
Rna Regulation ◽  
Global Regulators ◽  
Expression Of Genes ◽  
Non Coding Rna ◽  
6S Rna ◽  
Altered Regulation

6S RNA is a small, non-coding RNA that interacts directly with σ 70-RNA polymerase and regulates transcription at many σ 70-dependent promoters. Here, we demonstrate that 6S RNA regulates transcription of relA, which encodes a ppGpp synthase. The 6S RNA-dependent regulation of relA expression results in increased ppGpp levels during early stationary phase in cells lacking 6S RNA. These changes in ppGpp levels, although modest, are sufficient to result in altered regulation of transcription from σ 70-dependent promoters sensitive to ppGpp, including those promoting expression of genes involved in amino acid biosynthesis and rRNA. These data place 6S RNA as another player in maintaining appropriate gene expression as cells transition into stationary phase. Independent of this ppGpp-mediated 6S RNA-dependent regulation, we also demonstrate that in later stationary phase, 6S RNA continues to downregulate transcription in general, and specifically at a subset of the amino acid promoters, but through a mechanism that is independent of ppGpp and which we hypothesize is through direct regulation. In addition, 6S RNA-dependent regulation of σ S activity is not mediated through observed changes in ppGpp levels. We suggest a role for 6S RNA in modulating transcription of several global regulators directly, including relA, to downregulate expression of key pathways in response to changing environmental conditions.

scholarly journals Nuclear RNA regulation by XRN2 and XTBD family proteins

2021 ◽  
Author(s):  
İlkin Aygün ◽  
Takashi S. Miki
Keyword(s):  
Rna Regulation ◽  
Nuclear Rna

scholarly journals Non-coding RNA regulation in reproduction: Their potential use as biomarkers

2019 ◽  
Vol 4 (2) ◽  
pp. 54-62 ◽  
Author(s):  
Vanesa Robles ◽  
David G. Valcarce ◽  
Marta F. Riesco
Keyword(s):  
Rna Regulation ◽  
Non Coding Rna ◽  
Potential Use

scholarly journals Identification of specific microRNA–messenger RNA regulation pairs in four subtypes of breast cancer

2020 ◽  
Vol 14 (3) ◽  
pp. 120-126
Author(s):  
Ling Guo ◽  
Aihua Zhang ◽  
Jie Xiong
Keyword(s):  
Breast Cancer ◽  
Messenger Rna ◽  
Rna Regulation

Micro-RNA regulation of the angiogenic response in the diabetic retina

2020 ◽  
Vol 95 (1) ◽  
pp. 1-3
Author(s):  
H.C. Campos-Borges ◽  
S.M. Sanz-González ◽  
V. Zanón-Moreno ◽  
J.M. Millán Salvador ◽  
M.D. Pinazo-Duran
Keyword(s):  
Micro Rna ◽  
Rna Regulation ◽  
Angiogenic Response ◽  
Diabetic Retina

scholarly journals Regulatory landscape of the Hox transcriptome

2018 ◽  
Vol 62 (11-12) ◽  
pp. 693-704 ◽  
Author(s):  
Ana Casaca ◽  
Gabriel M. Hauswirth ◽  
Heidi Bildsoe ◽  
Moisés Mallo ◽  
Edwina McGlinn
Keyword(s):  
Translational Control ◽  
Noncoding Rna ◽  
Current Knowledge ◽  
Developmental Systems ◽  
Rna Regulation ◽  
Polycistronic Transcription ◽  
Hox Protein ◽  
Post Transcriptional Regulation ◽  
Protein Output ◽  
Cluster Gene

Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.

scholarly journals Development of a new extraction method based on high-intensity ultra-sonication to study RNA regulation of the filamentous cyanobacteria Planktothrix

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222029 ◽  
Author(s):  
Sandra Kim Tiam ◽  
Katia Comte ◽  
Caroline Dalle ◽  
Charlotte Duval ◽  
Claire Pancrace ◽  
...  
Keyword(s):  
High Intensity ◽  
Extraction Method ◽  
Filamentous Cyanobacteria ◽  
Rna Regulation

Melatonin restores the pluripotency of long‐term‐cultured embryonic stem cells through melatonin receptor‐dependent m6A RNA regulation

2020 ◽  
Vol 69 (2) ◽  
Author(s):  
Lei Yang ◽  
Xuefei Liu ◽  
Lishuang Song ◽  
Guanghua Su ◽  
Anqi Di ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Melatonin Receptor ◽  
Rna Regulation
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