scholarly journals Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.

1993 ◽  
Vol 7 (2) ◽  
pp. 216-228 ◽  
Author(s):  
M D Perry ◽  
W Li ◽  
C Trent ◽  
B Robertson ◽  
A Fire ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Cell Signaling ◽  
Sex Determination ◽  
Molecular Characterization ◽  
Direct Role

scholarly journals Molecular characterization of the transition to mid-life in Caenorhabditis elegans

AGE ◽  
2012 ◽  
Vol 35 (3) ◽  
pp. 689-703 ◽  
Author(s):  
D. Mark Eckley ◽  
Salim Rahimi ◽  
Sandra Mantilla ◽  
Nikita V. Orlov ◽  
Christopher E. Coletta ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization

Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans

2006 ◽  
Vol 34 (5) ◽  
pp. 942-948 ◽  
Author(s):  
J. Dillon ◽  
N.A. Hopper ◽  
L. Holden-Dye ◽  
V. O'Connor
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate Receptor ◽  
Model Organism ◽  
Metabotropic Glutamate ◽  
C Elegans ◽  
Genes Encoding ◽  
G Protein Coupled

mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of three distinct subclasses of receptor. Our transcript analysis highlights potential for complex gene regulation with respect to both expression and splicing. Further, we identify that the predicted proteins encoded by mgls harbour structural motifs that are likely to regulate function. Taken together, this molecular characterization provides a platform to further investigate mGluR function in the model organism C. elegans.

scholarly journals Ammonia excretion in Caenorhabditis elegans: Physiological and molecular characterization of the rhr-2 knock-out mutant

2016 ◽  
Vol 195 ◽  
pp. 46-54 ◽  
Author(s):  
Aida Adlimoghaddam ◽  
Michael J. O'Donnell ◽  
Jay Kormish ◽  
Sheena Banh ◽  
Jason R. Treberg ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization ◽  
Ammonia Excretion ◽  
Knock Out

Molecular characterization of the Caenorhabditis elegans REF-1 family member, hlh-29/hlh-28

2007 ◽  
Vol 1769 (1) ◽  
pp. 5-19 ◽  
Author(s):  
Tracee L. McMiller ◽  
Denise Sims ◽  
Tameshia Lee ◽  
Tiffany Williams ◽  
Casonya M. Johnson
Keyword(s):  
Caenorhabditis Elegans ◽  
Family Member ◽  
Molecular Characterization

scholarly journals fog-2, a germ-line-specific sex determination gene required for hermaphrodite spermatogenesis in Caenorhabditis elegans.

Genetics ◽  
1988 ◽  
Vol 119 (1) ◽  
pp. 43-61 ◽  
Author(s):  
T Schedl ◽  
J Kimble
Keyword(s):  
Caenorhabditis Elegans ◽  
Sex Determination ◽  
Germ Line ◽  
Negative Regulator ◽  
Loss Of Function ◽  
Wild Type ◽  
Negative Regulators ◽  
Nematode Caenorhabditis Elegans ◽  
Isolation And Characterization

Abstract This paper describes the isolation and characterization of 16 mutations in the germ-line sex determination gene fog-2 (fog for feminization of the germ line). In the nematode Caenorhabditis elegans there are normally two sexes, self-fertilizing hermaphrodites (XX) and males (XO). Wild-type XX animals are hermaphrodite in the germ line (spermatogenesis followed by oogenesis), and female in the soma. fog-2 loss-of-function mutations transform XX animals into females while XO animals are unaffected. Thus, wild-type fog-2 is necessary for spermatogenesis in hermaphrodites but not males. The fem genes and fog-1 are each essential for specification of spermatogenesis in both XX and XO animals. fog-2 acts as a positive regulator of the fem genes and fog-1. The tra-2 and tra-3 genes act as negative regulators of the fem genes and fog-1 to allow oogenesis. Two models are discussed for how fog-2 might positively regulate the fem genes and fog-1 to permit spermatogenesis; fog-2 may act as a negative regulator of tra-2 and tra-3, or fog-2 may act positively on the fem genes and fog-1 rendering them insensitive to the negative action of tra-2 and tra-3.

Sign in / Sign up

Export Citation Format

Share Document