scholarly journals Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila.

1993 ◽  
Vol 7 (4) ◽  
pp. 633-646 ◽  
Author(s):  
H J Doyle ◽  
J M Bishop
Keyword(s):  
Pattern Formation ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Embryonic Pattern Formation

Drosophila atonal controls photoreceptor R8-specific properties and modulates both receptor tyrosine kinase and Hedgehog signalling

Development ◽  
2000 ◽  
Vol 127 (8) ◽  
pp. 1681-1689 ◽  
Author(s):  
N.M. White ◽  
A.P. Jarman
Keyword(s):  
Pattern Formation ◽  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Compound Eye ◽  
Eye Development ◽  
Axon Pathfinding ◽  
Proneural Gene ◽  
Hedgehog Signalling ◽  
Drosophila Eye

During Drosophila eye development, the proneural gene atonal specifies founding R8 photoreceptors of individual ommatidia, evenly spaced relative to one another in a pattern that prefigures ommatidial organisation in the mature compound eye. Beyond providing neural competence, however, it has remained unclear to what extent atonal controls specific R8 properties. We show here that reduced Atonal function gives rise to R8 photoreceptors that are functionally compromised: both recruitment and axon pathfinding defects are evident. Conversely, prolonged Atonal expression in R8 photoreceptors induces defects in inductive recruitment as a consequence of hyperactive EGFR signalling. Surprisingly, such prolonged expression also results in R8 pattern formation defects in a process associated with both Hedgehog and Receptor Tyrosine Kinase signalling. Our results strongly suggest that Atonal regulates signalling and other properties of R8 precursors.

Emerging Receptor Tyrosine Kinase Drug Targets: Implications for Antibody-Based Therapies for Oncology and Immunologic Disorders

2015 ◽  
Vol 20 (5-6) ◽  
pp. 485-508 ◽  
Author(s):  
Theresa M. LaVallee ◽  
Diego Alvarado ◽  
Andrew J. Garton ◽  
E. Sergio Trombetta ◽  
Richard Gedrich ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Drug Targets

Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells

Diabetes ◽  
1991 ◽  
Vol 40 (11) ◽  
pp. 1440-1448 ◽  
Author(s):  
H. K. Muller ◽  
M. Kellerer ◽  
B. Ermel ◽  
A. Muhlhofer ◽  
B. Obermaier-Kusser ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Insulin Receptor ◽  
Receptor Tyrosine Kinase ◽  
Fat Cells ◽  
Insulin Receptor Tyrosine Kinase ◽  
Protein Kinase C Inhibitors ◽  
Kinase C ◽  
Rat Fat Cells
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