scholarly journals Two different, mutually exclusively distributed,TP53mutations in ovarian and peritoneal tumor tissues of a serous ovarian cancer patient: indicative for tumor origin?

2017 ◽  
Vol 3 (4) ◽  
pp. a001461 ◽  
Author(s):  
Nyamdelger Sukhbaatar ◽  
Anna Bachmayr-Heyda ◽  
Katharina Auer ◽  
Stefanie Aust ◽  
Simon Deycmar ◽  
...  
2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17045-e17045 ◽  
Author(s):  
Panagiotis Konstantinopoulos ◽  
Sangeetha Palakurthi ◽  
Qing Zeng ◽  
Shan Zhou ◽  
Joyce F. Liu ◽  
...  

Author(s):  
Claire R. Morden ◽  
Ally C. Farrell ◽  
Mirka Sliwowski ◽  
Zelda Lichtensztejn ◽  
Alon D. Altman ◽  
...  

2014 ◽  
Vol 8 (3) ◽  
pp. 656-668 ◽  
Author(s):  
Monique D. Topp ◽  
Lynne Hartley ◽  
Michele Cook ◽  
Valerie Heong ◽  
Emma Boehm ◽  
...  

2019 ◽  
Vol 5 (6) ◽  
pp. a004341 ◽  
Author(s):  
Ilaria Colombo ◽  
Swati Garg ◽  
Arnavaz Danesh ◽  
Jeffrey Bruce ◽  
Patricia Shaw ◽  
...  

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 505 ◽  
Author(s):  
Besnik Muqaku ◽  
Dietmar Pils ◽  
Johanna C. Mader ◽  
Stefanie Aust ◽  
Andreas Mangold ◽  
...  

It is still a question of debate whether neutrophils, often found in the tumor microenvironment, mediate tumor-promoting or rather tumor-inhibiting activities. The present study focuses on the involvement of neutrophils in high grade serous ovarian cancer (HGSOC). Macroscopic features classify two types of peritoneal tumor spread in HGSOC. Widespread and millet sized lesions characterize the miliary type, while non-miliary metastases are larger and associated with better prognosis. Multi-omics and FACS data were generated from ascites samples. Integrated data analysis demonstrates a significant increase of neutrophil extracellular trap (NET)-associated molecules in non-miliary ascites samples. A co-association network analysis performed with the ascites data further revealed a striking correlation between NETosis-associated metabolites and several eicosanoids. The congruence of data generated from primary neutrophils with ascites analyses indicates the predominance of NADPH oxidase 2 (NOX)-independent NETosis. NETosis is associated with protein S100A8/A9 release. An increase of the S100A8/CRP abundance ratio was found to correlate with favorable survival of HGSOC patients. The analysis of additional five independent proteome studies with regard to S100A8/CRP ratios confirmed this observation. In conclusion, NET formation seems to relate with better cancer patient outcome.


2021 ◽  
Vol 70 (3) ◽  
pp. 843-856
Author(s):  
Kathryn M. Appleton ◽  
Ashley K. Elrod ◽  
Katy A. Lassahn ◽  
Stephen Shuford ◽  
Lillia M. Holmes ◽  
...  

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