Murine-leukemia-virus-related Cell-surface Antigens as Serological Markers of AKR Ecotropic, Xenotropic, and Dualtropic Viruses

1980 ◽  
Vol 44 (0) ◽  
pp. 1255-1264 ◽  
Author(s):  
P. V. O'Donnell ◽  
E. Stockert ◽  
Y. Obata ◽  
A. B. DeLeo ◽  
L. J. Old
Keyword(s):  
Cell Surface ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Surface Antigens ◽  
Serological Markers ◽  
Cell Surface Antigens ◽  
Related Cell ◽  
Murine Leukemia

scholarly journals Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma.

1977 ◽  
Vol 146 (3) ◽  
pp. 720-734 ◽  
Author(s):  
A B DeLeo ◽  
H Shiku ◽  
T Takahashi ◽  
M John ◽  
L J Old
Keyword(s):  
Cell Surface ◽  
Cell Lines ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Surface Antigens ◽  
Cell Surface Antigens ◽  
Cultured Fibroblasts ◽  
Chemically Induced ◽  
Sarcoma Cells ◽  
Murine Leukemia

As background for a serological definition of the unique antigens of chemically induced sarcomas, we have typed a series of fibroblast and sarcoma cell lines of BALB/c and C57BL/6 origin by cytoxicity and absorption tests for murine leukemia virus (MuLV)-related cell surface antigens and known alloantigens. 7 of the 17 cultured lines expressed the range of cell surface antigens associated with MuLV (GIX, GCSA, gp70, p30), and this was invariably associated with MuLV production. In nonproducer lines of C57BL/6 (but not BALB/c) origin, a MuLV-gp70-like molecule was found on the surface of fibroblasts and sarcoma cells. The alloantigenic phenotype of these MuLV+ and MuLV- cell lines was H-2D+, H-2K+, Thy-1.2+ or -, PC.1+ or -, Lyt-1.2-, Lyt-2.2-, Ia.7-, and TL.2-. A unique antigen was defined on the BALB/c ascites sarcoma Meth A with antisera prepared in BALB/c or (BALB/c X C57BL/6)F1 mice. Tissue culture lines derived from this tumor were MuLV-, which facilitated serological study of the antigen. Absorption analysis indicated that the antigen was restricted to Meth A; it could not be detected in normal or fetal BALB/c tissue MuLV+ or MuLV- fibroblast lines, 12 syngeneic or allogeneic sarcomas, or normal lymphoid cells from 13 different inbred mouse strains.

Correlation between various cell-surface antigens induced by murine leukemia virus in the rat: Serological analysis

1973 ◽  
Vol 11 (3) ◽  
pp. 575-585 ◽  
Author(s):  
Noboru Kuzumaki ◽  
Noritoshi Takeichi ◽  
Fujiro Sendo ◽  
Takao Kodama ◽  
Hiroshi Kobayashi
Keyword(s):  
Cell Surface ◽  
Murine Leukemia Virus ◽  
Leukemia Virus ◽  
Surface Antigens ◽  
Serological Analysis ◽  
Cell Surface Antigens ◽  
Murine Leukemia
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