Post-reconstruction 3D single-distance phase retrieval for multi-stage phase-contrast tomography with photon-counting detectors

2019 ◽  
Vol 26 (2) ◽  
pp. 510-516 ◽  
Author(s):  
Francesco Brun ◽  
Luca Brombal ◽  
Vittorio Di Trapani ◽  
Pasquale Delogu ◽  
Sandro Donato ◽  
...  
Keyword(s):  
Phase Contrast ◽  
Phase Retrieval ◽  
Photon Counting ◽  
X Ray ◽  
Multi Stage ◽  
Mastectomy Specimen ◽  
X Ray Computed ◽  
Photon Counting Detectors ◽  
3D Volume ◽  
Phase Contrast Tomography

In the case of single-distance propagation-based phase-contrast X-ray computed tomography with synchrotron radiation, the conventional reconstruction pipeline includes an independent 2D phase retrieval filtering of each acquired projection prior to the actual reconstruction. In order to compensate for the limited height of the X-ray beam or the small sensitive area of most modern X-ray photon-counting detectors, it is quite common to image large objects with a multi-stage approach, i.e. several acquisitions at different vertical positions of the sample. In this context, the conventional reconstruction pipeline may introduce artifacts at the margins of each vertical stage. This article presents a modified computational protocol where a post-reconstruction 3D volume phase retrieval is applied. By comparing the conventional 2D and the proposed 3D reconstructions of a large mastectomy specimen (9 cm in diameter and 3 cm in height), it is here shown that the 3D approach compensates for the multi-stage artifacts, it avoids refined projection stitching, and the image quality in terms of spatial resolution, contrast and contrast-to-noise ratio is preserved.

scholarly journals Noninvasive 3D Structural Analysis of Arthropod by Synchrotron X-Ray Phase Contrast Tomography

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Shengkun Yao ◽  
Yunbing Zong ◽  
Jiadong Fan ◽  
Zhibin Sun ◽  
Huaidong Jiang
Keyword(s):  
Phase Contrast ◽  
Phase Retrieval ◽  
High Efficiency ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Circulatory System ◽  
Low Contrast ◽  
X Ray ◽  
Potential Applications ◽  
Phase Contrast Tomography

X-ray imaging techniques significantly advanced our understanding of materials and biology, among which phase contrast X-ray microscopy has obvious advantages in imaging biological specimens which have low contrast by conventional absorption contrast microscopy. In this paper, three-dimensional microstructure of arthropod with high contrast has been demonstrated by synchrotron X-ray in-line phase contrast tomography. The external morphology and internal structures of an earthworm were analyzed based upon tomographic reconstructions with and without phase retrieval. We also identified and characterized various fine structural details such as the musculature system, the digestive system, the nervous system, and the circulatory system. This work exhibited the high efficiency, high precision, and wide potential applications of synchrotron X-ray phase contrast tomography in nondestructive investigation of low-density materials and biology.

Hard X-ray phase-contrast tomography of non-homogeneous specimens: grating interferometryversuspropagation-based imaging

2016 ◽  
Vol 23 (5) ◽  
pp. 1202-1209 ◽  
Author(s):  
Maite Ruiz-Yaniz ◽  
Irene Zanette ◽  
Adrian Sarapata ◽  
Lorenz Birnbacher ◽  
Mathias Marschner ◽  
...  
Keyword(s):  
Experimental Data ◽  
Phase Contrast ◽  
Phase Retrieval ◽  
Phase Contrast Imaging ◽  
Contrast Imaging ◽  
Homogeneous Sample ◽  
X Ray ◽  
Practical Applications ◽  
Phase Contrast Tomography ◽  
Complex Valued

X-ray phase-contrast imaging is an effective approach to drastically increase the contrast and sensitivity of microtomographic techniques. Numerous approaches to depict the real part of the complex-valued refractive index of a specimen are nowadays available. A comparative study using experimental data from grating-based interferometry and propagation-based phase contrast combined with single-distance phase retrieval applied to a non-homogeneous sample is presented (acquired at beamline ID19-ESRF). It is shown that grating-based interferometry can handle density gradients in a superior manner. The study underlines the complementarity of the two techniques for practical applications.

Phase-Contrast Tomographic Imaging Using an X-ray Interferometer

1998 ◽  
Vol 5 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Atsushi Momose ◽  
Tohoru Takeda ◽  
Yuji Itai ◽  
Akio Yoneyama ◽  
Keiichi Hirano
Keyword(s):  
Phase Contrast ◽  
Phase Retrieval ◽  
X Rays ◽  
Contrast Imaging ◽  
X Ray ◽  
Tomographic Image Reconstruction ◽  
X Ray Computed ◽  
Preliminary Study ◽  
Breast Tissues

Apparatus for phase-contrast X-ray computed tomography using a monolithic X-ray interferometer is presented with some observational results for human breast tissues. Structures characteristic of the tissues were revealed in the phase-contrast tomograms. The procedure of image analysis consists of phase retrieval from X-ray interference patterns and tomographic image reconstruction from the retrieved phase shift. Next, feasibility of phase-contrast imaging using a two-crystal X-ray interferometer was studied aiming at in vivo observation in the future. In a preliminary study, the two-crystal X-ray interferometer was capable of generating fringes of 70% visibility using synchrotron X-rays.

scholarly journals Constrained Non-Linear Phase Retrieval for Single Distance Xray Phase Contrast Tomography

2020 ◽  
Vol 2020 (14) ◽  
pp. 146-1-146-8
Author(s):  
K. Aditya Mohan ◽  
Dilworth Y. Parkinson ◽  
Jefferson A. Cuadra
Keyword(s):  
Inverse Problem ◽  
Refractive Index ◽  
Phase Contrast ◽  
Phase Retrieval ◽  
Transmission Function ◽  
Linear Phase ◽  
Linear Inverse Problem ◽  
X Ray ◽  
Non Linear ◽  
Phase Contrast Tomography

X-ray phase contrast tomography (XPCT) is widely used for 3D imaging of objects with weak contrast in X-ray absorption index but strong contrast in refractive index decrement. To reconstruct an object imaged using XPCT, phase retrieval algorithms are first used to estimate the X-ray phase projections, which is the 2D projection of the refractive index decrement, at each view. Phase retrieval is followed by refractive index decrement reconstruction from the phase projections using an algorithm such as filtered back projection (FBP). In practice, phase retrieval is most commonly solved by approximating it as a linear inverse problem. However, this linear approximation often results in artifacts and blurring when the conditions for the approximation are violated. In this paper, we formulate phase retrieval as a non-linear inverse problem, where we solve for the transmission function, which is the negative exponential of the projections, from XPCT measurements. We use a constraint to enforce proportionality between phase and absorption projections. We do not use constraints such as large Fresnel number, slowly varying phase, or Born/Rytov approximations. Our approach also does not require any regularization parameter tuning since there is no explicit sparsity enforcing regularization function. We validate the performance of our non-linear phase retrieval (NLPR) method using both simulated and real synchrotron datasets. We compare NLPR with a popular linear phase retrieval (LPR) approach and show that NLPR achieves sharper reconstructions with higher quantitative accuracy.

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