Isolation, evaluation of bioactivity and structure determination of amethinol A, a prototypic amethane diterpene from Isodon amethystoides bearing a six/five/seven-membered carbon-ring system
2018 ◽
Vol 74
(5)
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pp. 635-640
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Keyword(s):
We report the isolation of a novel diterpene, designated as `amethane', from Isodon amethystoides (Lamiaceae). The diterpene [amethinol A; systematic name: (4aR,4bR,7R,10aS)-4b,7-dihydroxy-7-isopropyl-1,1-dimethyl-9-oxododecahydrobenzo[a]azulene-4a(2H)-carboxylic acid], possesses a unique skeleton containing a six/five/seven-membered tricyclic system. Intermolecular O—H...O close contacts were found to the carboxyl, carbonyl and hydroxy groups, connecting molecules into a two-dimensional structure. A possible biosynthetic pathway has been proposed. In addition, the compound was evaluated for its biological activities against different disease targets, and was found to significantly attenuate RORγt-dependent autoimmune responses.
1991 ◽
Vol 29
(4)
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pp. 327-332
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2019 ◽
pp. 129-162
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1966 ◽
Vol 88
(20)
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pp. 4583-4588
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1982 ◽
Vol 39
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pp. 183-231
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1982 ◽
Vol 37
(10)
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pp. 1103-1118
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2016 ◽
Vol 72
(10)
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pp. 1488-1491
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