Unexpected synthesis and crystal structure of N-{2-[2-(2-acetylethenyl)phenoxy]ethyl}-N-ethenyl-4-methylbenzenesulfonamide
2020 ◽
Vol 76
(12)
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pp. 1851-1853
Keyword(s):
The title compound, C21H23NO4S, obtained by alkaline treatment of 1,5-bis(1-phenoxy)-3-azapentane at moderate heating, is a N-tosylated secondary vinylamine. An intramolecular S=O...H—C hydrogen bond generates a 13-membered ring. The benzalacetone moiety adopts a trans conformation with respect to the C=C double bond, which is slightly longer than usual due to the conjugation with a neighbouring acetyl group. Theoretical predictions of potential biological activities were performed, suggesting that the title compound can inhibit gluconate 2-dehydrogenase (85% probability), as well as to act as a mucomembranous protector (73%).
2007 ◽
Vol 63
(11)
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pp. o4278-o4278
Keyword(s):
2015 ◽
Vol 71
(7)
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pp. o519-o520
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2020 ◽
Vol 76
(10)
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pp. 1653-1656
2012 ◽
Vol 68
(12)
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pp. o485-o487
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2015 ◽
Vol 71
(1)
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pp. 104-106
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2009 ◽
Vol 65
(6)
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pp. o1226-o1226
Keyword(s):
2021 ◽
Vol 77
(6)
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pp. 615-617
Keyword(s):
2016 ◽
Vol 72
(9)
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pp. 1239-1241
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2014 ◽
Vol 70
(11)
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pp. o1167-o1167
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Keyword(s):
2000 ◽
Vol 57
(1)
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pp. o18-o19
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Keyword(s):