Background: HIV-infected women increase in number due to biological condition, poor knowledge on HIV/AIDS, and low bargaining position. Aim & Objective: This study aimed to study capacity building, structural adjustment and culture changes in overcoming HIV/AIDS in Surakarta Indonesia. Methods and Material: Data was conducted through interview, observation, and documentation. Data was validated using source triangulation and analyzed using Longwe’s Women Empowering Framework. Results: Responsive-gender HIV/AIDS coping procedures in Surakarta to encourage woman’s reproductive right and realize gender equality. Conclusions: Capacity building, structural adjustment and cultural change is to improve, develop and integrate empowerment of women infected with HIV/AIDS.