scholarly journals Ankle edema after administration of selective serotonin reuptake inhibitors

2018 ◽  
Vol 10 (1) ◽  
pp. 25-26
Author(s):  
Konstantinos Kontoangelos ◽  
Marina Ecomomou ◽  
Charalambos Papageorgiou
Keyword(s):  
Psychotropic Medication ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Clinical Manifestations ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Drug Induced ◽  
Skin Reactions ◽  
Wide Range ◽  
Life Threatening

Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Drug-induced skin reactions to psychotropic medication are usually associated with antiepileptic drugs. However, a significant role can be assigned to selective serotonin reuptake inhibitors. We report a case of a female patient, who after approximately one month therapy with escitalopram developed a bilateral ankle edema, which resolved completely within the first week following its discontinuation. Although serious complications are rare, clinicians should be aware of severe skin complications in patients treated with antidepressants, which necessitate careful clinical monitoring and management. Individualization of pharmacotherapy is crucial, together with regular evaluation of safety and tolerance of the treatment.

scholarly journals Ankle edema after administration of selective serotonin reuptake inhibitors

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Konstantinos Kontoangelos ◽  
Marina Ecomomou ◽  
Charalambos Papageorgiou
Keyword(s):  
Psychotropic Medication ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Clinical Manifestations ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Drug Induced ◽  
Skin Reactions ◽  
Wide Range ◽  
Life Threatening

Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Druginduced skin reactions to psychotropic medication are usually associated with antiepileptic drugs. However, a significant role can be assigned to selective serotonin reuptake inhibitors. We report a case of a female patient, who after approximately one month therapy with escitalopram developed a bilateral ankle edema, which resolved completely within the first week following its discontinuation. Although serious complications are rare, clinicians should be aware of severe skin complications in patients treated with antidepressants, which necessitate careful clinical monitoring and management. Individualization of pharmacotherapy is crucial, together with regular evaluation of safety and tolerance of the treatment.

Selective serotonin reuptake inhibitors in affective disorders -II. Efficacy and quality of life

1998 ◽  
Vol 12 (4_suppl) ◽  
pp. S21-S54 ◽  
Author(s):  
Paul J. Goodnick ◽  
Burton J. Goldstein
Keyword(s):  
Quality Of Life ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
Quality Of Data ◽  
Affective Symptoms ◽  
Wide Range ◽  
Favorable Side Effect Profile

Since their introduction, the selective serotonin reuptake inhibitors (SSRIs) have become one of the most widely used classes of medication in psychiatry. Their popularity is based on apparent efficacy over a wide range of disorders and a favorable side-effect profile. However, as with any psychotropic medication, considerable data are required to define where a drug works and where it does not. There is now a wealth of evidence demonstrating that SSRIs may differ in their efficacy profiles in certain depressive symptoms, in different subtypes of depression, with respect to their ability to maintain efficacy over time, on broader outcomes such as quality of life, and in the consistency of the usually effective minimum therapeutic dose across the age spectrum and across indications. Although this review includes data on all SSRIs, it focuses on fluoxetine and sertraline, which in addition to being the most widely used SSRIs are also the most widely studied. The relative quantity and quality of data on these two SSRIs means that it is possible to make relatively firm inferences regarding their differential effects on affective symptoms and quality of life.

scholarly journals FARMAKOTERAPI GANGGUAN ANSIETAS DAN PENGARUH JENIS KELAMIN TERHADAP EFIKASI ANTIANSIETAS

2020 ◽  
Vol 8 (1) ◽  
pp. 96-103
Author(s):  
Fatimah Azzahra ◽  
Rasmi Zakiah Oktarlina ◽  
High Boy Karumulborg Hutasoit
Keyword(s):  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Serotonin Reuptake Inhibitors ◽  
Selective Serotonin ◽  
First Line ◽  
General Signs ◽  
Keywords Anxiety ◽  
Global Population

ABSTRAK Ansietas merupakan perasaan difus, yang sangat tidak menyenangkan dan tidak menentu tentang sesuatu yang akan terjadi. Menurut WHO, jumlah populasi global yang menderita ansietas pada tahun 2017 diperkirakan mencapai 3.8%. Estimasi total dari jumlah individu yang menderita ansietas di dunia adalah 284 juta orang. Hal ini menunjukkan peningkatan yang cukup tinggi dari tahun 2005 yakni sekitar 15.1%. Manifestasi klinis dari ansietas berbeda tergantung pada bentuk gangguannya, tetapi tanda dan gejala umum dari ansietas memeiliki karakteristik yang terdiri dari dua komponen yaitu fisik dan emosional yang memengaruhi proses kognitif seseorang. Pengobatan ansietas dapat menggunakan obat – obatan antiansietas, psikoterapi, ataupun keduanya. Lini pertama dari farmakoterapi ansietas adalah Selective Serotonin Reuptake Inhibitors (SSRIs) yang biasanya digunakan sebagai antidepresi. SSRIs dipilih sebagai lini pertama karena memiliki efek samping yang lebih rendah dibandingkan obat golongan lainnya. Terdapat pengaruh jenis kelamin terhadap efikasi antiansietas yang berguna terhadap pemilihan antiansietas.  Kata Kunci : Ansietas, Antiansietas, Farmakoterapi, Pengobatan   ABSTRACT Anxiety is a diffuse feeling, which is very unpleasant and uncertain about something that will happen. According to WHO, the total global population suffering from anxiety in 2017 is estimated to reach 3.8%. The total estimated number of people living with anxiety in the world is 284 million people. This shows a fairly high increase from 2005 which was around 15.1%. Clinical manifestations of anxiety is different depending on the form of the disorder, but the general signs and symptoms of anxiety have characteristics that consist of two components, that is physical and emotional that affect someone cognitive processes. The treatment of anxiety can using drugs, psychotherapy, or both. The first line of pharmacotherapy for anxiety is Selective Serotonin Reuptake Inhibitors (SSRIs), which are usually used as antidepressants. SSRIs were chosen as first-line because they have lower side effects than other class of drugs. There is an effect of sex on the efficacy of antianxiety that is useful for selection of the antianxiety.  Keywords : Anxiety, Antianxiety, Pharmacotherapy, Treatment

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