This research paper discusses about a design of an amplifier for its use in an Analog Front End for Biomedical signal acquisition. The design of an AFE is also specific to the signal of interest. This paper deals with the design of an Analog Front End using 180nm process. An amplifier is a key component of an AFE. For instrumentation amplifier to satisfy theoretical results the OPAMP used must be close to ideal. The simulations are performed using TANNER EDA tool.