Kinetic analysis of graphene oxide sheet and protein interactions using surface plasmon resonance biosensors

Author(s):  
Teng-Yi Huang ◽  
Nan-Fu Chiu ◽  
Hsin-Chih Lai
2009 ◽  
Vol 53 (4) ◽  
pp. 1528-1531 ◽  
Author(s):  
Françoise Banères-Roquet ◽  
Maxime Gualtieri ◽  
Philippe Villain-Guillot ◽  
Martine Pugnière ◽  
Jean-Paul Leonetti

ABSTRACT The pharmacologic effect of an antibiotic is directly related to its unbound concentration at the site of infection. Most commercial antibiotics have been selected in part for their low propensity to interact with serum proteins. These nonspecific interactions are classically evaluated by measuring the MIC in the presence of serum. As higher-throughput technologies tend to lose information, surface plasmon resonance (SPR) is emerging as an informative medium-throughput technology for hit validation. Here we show that SPR is a useful automatic tool for quantification of the interaction of model antibiotics with serum proteins and that it delivers precise real-time kinetic data on this critical parameter.


Plasmonics ◽  
2016 ◽  
Vol 12 (6) ◽  
pp. 1991-1997 ◽  
Author(s):  
Bahar Meshginqalam ◽  
Mohammad Taghi Ahmadi ◽  
Razali Ismail ◽  
Arash Sabatyan

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