Ultra-high sensitivity of the non-immunological affinity of graphene oxide-peptide-based surface plasmon resonance biosensors to detect human chorionic gonadotropin

2017 ◽  
Vol 94 ◽  
pp. 351-357 ◽  
Author(s):  
Nan-Fu Chiu ◽  
Chia-Tzu Kuo ◽  
Ting-Li Lin ◽  
Chia-Chen Chang ◽  
Chen-Yu Chen
2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Iraj S. Amiri ◽  
Siti Anis Khairani Alwi ◽  
Sofiah Atirah Raya ◽  
Nur Aina’a Mardhiah Zainuddin ◽  
Nurul Syazwani Rohizat ◽  
...  

AbstractThis research focuses on the side-polished Single-Mode Optical Fibers (SMOF) as refractive index (RI) sensor utilizing properties of Surface Plasmon Resonance. The SMOF with cladding stripped off shows a D-shaped optical fiber with high sensitivity functionalization. Here we show silver protected by graphene oxide (GO) as viable candidates. A few layers of GO on top of silver thin layer were applied as a material to overcome silver coating degradation process. This silver/GO sensor was characterized using various RIs of analyte likely deionized water and alcohol solutions. Sensor with GO has shown fast response and high sensitivity in respect of RI, where sensitivity increases in range from 1.30 to 1.34 RIU (refractive index unit). This device shows highest sensitivity of up to 833.33 nm/ RIU. The polishing process using SMOF stops at few microns above the core of the fiber with the drop of output power fixed to be 1 dB as an indication to standardize the amount of cladding been removed. The thickness of 30 nm Ag was deposited using electron beam evaporation method on D-shaped optical fiber with subsequent protected layer of GO in solutions form. The use of COMSOL Multiphysics has also been carried out to observe numerical findings. The response of the GO has shown a sensitivity improvement which proves new promising approaches for the newly developed sensors.


PIERS Online ◽  
2008 ◽  
Vol 4 (7) ◽  
pp. 746-750 ◽  
Author(s):  
Bing-Hung Chen ◽  
Yih-Chau Wang ◽  
Jia-Hng Lin

Nanomaterials ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1325 ◽  
Author(s):  
Ru-Jing Sun ◽  
Hung Ji Huang ◽  
Chien-Nan Hsiao ◽  
Yu-Wei Lin ◽  
Bo-Huei Liao ◽  
...  

A TiN-based substrate with high reusability presented high-sensitivity refractive index measurements in a home-built surface plasmon resonance (SPR) heterodyne phase interrogation system. TiN layers with and without additional inclined-deposited TiN (i-TiN) layers on glass substrates reached high bulk charge carrier densities of 1.28 × 1022 and 1.91 × 1022 cm−3, respectively. The additional 1.4 nm i-TiN layer of the nanorod array presented a detection limit of 6.1 × 10−7 RIU and was higher than that of the 46 nm TiN layer at 1.2 × 10−6 RIU when measuring the refractive index of a glucose solution. Furthermore, the long-term durability of the TiN-based substrate demonstrated by multiple processing experiments presented a high potential for various practical sensing applications.


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