Vibration screener is an important mechanism which is widely applied to metallurgy, building materials, chemical industry, grain, mine, etc. On the basis of deeply studying work principle and support structure of vibration screener, the paper conducts ZKB Linear vibration screener as study object. According to mass of vibration, vertical stiffness, horizontal stiffness, vertical amplitude, horizontal amplitude, and free high of vibration screener support spring, the paper conducts the lightest weight of support spring and the biggest fatigue safety factor as the objective function of multi-objective optimization design to establish a series of constraints. Then using of the penalty function method of optimization theory , the paper gets the optimal design results of support spring and gives the optimal design dimensions, which provides a reliable design method of support spring for the future design of vibration screener and reduce the blindness of the design .