A thermal-hydraulic model has been developed for describing the phenomenon of hydrodynamically-controlled dryout, or the boil-off phenomenon, in a vertical channel with a spatially-averaged or uniform heat flux. The use of the drift flux correlation for the void fraction profile, along with mass and energy balances for the system, leads to a dimensionless closed-form solution for the predictions of two-phase mixture levels and collapsed liquid levels. The physical significance of the governing dimensionless parameters are discussed. Comparisons with data from single-tube experiments, a 3 × 3 rod bundle experiment, and the Three Mile Island nuclear power plant show good agreement.