For the physiological signal monitoring applications, as a micro-controller based on field programmable gate array (FPGA) physiological parameters intelligent acquisition system is given, which has the advantages of low cost, high speed, low power consumption. FPGA is responsible for the completion of pulse sensor, the temperature sensor, acceleration sensor data acquisition and serial output and so on. Focuses on the design ideas and architecture of the various subsystems of the whole system, gives the internal FPGA circuit diagram of the entire system. The whole system is easy to implement and has a very good promotional value.