Design, develop and cost analysis of GPON triple play architecture without EDFA combiner for fixed wave length with high performance

2016 ◽  
Author(s):  
Md. Hayder Ali ◽  
Md. Saiful Islam
Keyword(s):  
Cost Analysis ◽  
High Performance ◽  
Wave Length ◽  
Triple Play

Validated HPLC Method for Quantification of a Novel Trk Inhibitor, Larotrectinib in Mice Plasma: Application to a Pharmacokinetic Study

Drug Research ◽  
2020 ◽  
Vol 70 (02/03) ◽  
pp. 101-106
Author(s):  
Harsha K. Tripathy ◽  
S.V. Nair Manju ◽  
Ashok Zakkula ◽  
Ram Murthi Bestha ◽  
Sreekanth Dittakavi ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
High Performance ◽  
Wave Length ◽  
Internal Standard ◽  
Hplc Method ◽  
Long Term Storage ◽  
Development And Validation ◽  
Orally Active ◽  
Regulatory Guideline

AbstractLarotrectinib, is an orally active novel small molecule approved for the treatment of solid tumors in pediatrics and adult patients. It acts by inhibiting tropomyosin receptor kinase. In this paper, we report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of larotrectinib in mice plasma as per the FDA regulatory guideline. Plasma samples processing was accomplished through simple protein precipitation using acetonitrile enriched with internal standard (IS, enasidenib). The chromatographic analysis was performed using a gradient mobile phase comprising 10 mM ammonium acetate and acetonitrile at a flow-rate of 0.8 mL/min on an X-Terra Phenyl column. The UV detection wave length was set at λmax 262 nm. Larotrectinib and the IS eluted at 3.85 and 6.60 min, respectively with a total run time of 8.0 min. The calibration curve was linear over a concentration range of 0.20–5.00 μg/mL (r2=≥0.992). The intra- and inter-day precision and accuracy results were within the acceptable limits. Results of stability studies indicated that larotrectinib was stable on bench-top, in auto-sampler, up to three freeze/thaw cycles and long-term storage at −80°C. The validated HPLC method was successfully applied to a pharmacokinetic study in mice.

scholarly journals A Novel and Rapid RP-HPLC Quantitative Method for the estimation of Canagliflozin in Human Plasma

2021 ◽  
Vol 12 (1) ◽  
pp. 93-101
Author(s):  
Ajitha A ◽  
Sujatha K ◽  
Abbulu K
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Quantitative Estimation ◽  
Wave Length ◽  
Potassium Dihydrogen Phosphate ◽  
Internal Standard ◽  
Accurate Method ◽  
Dihydrogen Phosphate ◽  
Chromatographic Technique ◽  
Limit Of Quantification

A simple, precise and accurate method was developed for the quantitative estimation of Canagliflozin in human plasma using Dapagliflozin as internal standard by Reverse Phase-High Performance Liquid Chromatographic technique. Chromatographic conditions were of stationary phase Phenomenex Luna C18 (2) (150 x 4.6 mm, 5m), Mobile phase 0.01 N Potassium dihydrogen Phosphate buffer pH (3.5±0.05) : acetonitrile in the ratio of 45:55 and flow rate at 1.0 ml/min, detection wave length was UV 222 nm, column oven temperature was maintained at 30ᵒC, and sample injection volume of 10 µL. Retention time of Canagliflozin was found to be about 8.7 min. Coefficient of Variation for Canagliflozin peak was 3.15 %, % recovery was 94.58 %. The linearity of method was studied from 0.06 µg/ml to 2.4 µg/ml (R2 = 0.999). The Signal to Noise ratio of lower limit of quantification (0.06 µg/ml) was found to be 50. The proposed bio-analytical method was validated by following ICH guidelines.

Next Generation Home Network and Home Gateway Associated with Optical Access

2010 ◽  
pp. 294-314
Author(s):  
Tetsuya Yokotani
Keyword(s):  
High Performance ◽  
Home Network ◽  
Home Networks ◽  
Functional Requirements ◽  
Next Generation ◽  
Home Gateway ◽  
Qos Guarantee ◽  
Triple Play ◽  
Generation Network ◽  
Triple Play Services

As optical broadband access networks have been popularized, triple play services using IP technologies, such as Internet access, IP telephony, and IP video distributing services, have been also popularized. However, consumers expect new services for a more comfortable life. Especially, when QoS guarantee and high reliable services are provided in NGN (Next Generation Network) era, various home network services over NGN are deployed. For this purpose, the home gateway has been installed in consumer houses for the connection between access and home networks, and providing various services to consumers. Even though, the broadband router currently plays a role similar to the home gateway, this home gateway should comprehend functionalities of the broadband router, and should have additional features. The functional requirements of such home gateway have been discussed in standard bodies. That is, the next generation home gateway in NGN era generally should have four features as follows; High performance for IP processing, Compliance with the interface of carrier grade infrastructure including NGN, Flexible platform for various services, and Easy management and maintenance. This chapter describes the standardization of the home gateway and, proposes its evolution scenario the present to the future. Then, it also proposes these four requirements, and technologies to comply with features described above.

LU decomposition

2020 ◽  
pp. 74-133
Author(s):  
Rob H. Bisseling
Keyword(s):  
Cost Analysis ◽  
Linear Systems ◽  
High Performance ◽  
Gaussian Elimination ◽  
Collective Communication ◽  
Dense Matrix ◽  
Lu Decomposition ◽  
Two Phase ◽  
Matrix Computations ◽  
Communication Method

This chapter discusses parallel dense matrix computations, in particular the solution of linear systems by LU decomposition with partial row pivoting. It first presents a general Cartesian scheme for the distribution of matrices. Based on BSP cost analysis, the square cyclic distribution is proposed as particularly suitable for matrix computations such as LU decomposition and Gaussian elimination. The chapter introduces two-phase broadcasting of vectors, which is a useful collective-communication method for sending copies of matrix rows or columns to a group of processors. It also discusses how to achieve high performance by delaying rank-1 matrix updates to create a multiple-rank update, which can be carried out by multiplying tall-and-skinny matrices in a cache-friendly manner. The high-performance parallel LU decomposition is tested on a top-ranking supercomputer, and its performance is analysed with respect to computation, communication, and synchronization.

scholarly journals DEVELOPMENT AND VALIDATION OF DAPAGLIFLOZIN BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD AND IT’S FORCED DEGRADATION STUDIES

2017 ◽  
Vol 10 (11) ◽  
pp. 101
Author(s):  
Shaik Shakirbasha ◽  
Sravanthi P
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Limit Of Detection ◽  
Wave Length ◽  
Reversed Phase ◽  
Forced Degradation ◽  
Column Temperature ◽  
Rp Hplc ◽  
Limit Of Quantitation

  Objective: To develop and validate a simple, selective, precise, and accurate method for the estimation of dapagliflozin using reversed-phase high-performance liquid chromatography (RP-HPLC) technique in bulk and tablet formulation.Methods: The proposed method utilizes chromatographic conditions hypersil BDS (250 mm × 4.6 mm, 5 μ), mobile phase was buffer:acetonitrile (60:40) ratio, flow rate was maintained 1 ml/minute, column temperature was set at 30°C, detection wave length was 245 nm, and diluent was mobile phase.Results: By injecting 5 times of the standard solution system suitability parameters were studied, and results were found well under the acceptance criteria. The linearity study was performed by taking 25-150% levels, and the R2 value was found to be 0.999, precision was found to be 0.5 for repeatability and 0.31 for intermediate precision. The % recovery was found to be 99.89%. Limit of detection and limit of quantitation were found to be 0.60 μg/ml and 1.81 μg/ml, respectively. The % purity was found to be 99.71%. Degradation study on dapagliflozin was performed and concluded that the purity threshold was more than purity angle and within the acceptable range.Conclusion: The developed RP-HPLC method for dapagliflozin was found to be simple, precise, accurate, reproducible, and cost effective. Statistical analysis of the developed method conforms that the proposed method is an appropriate and it can be useful for the routine analysis. This method gives the basic idea to the researcher who is working in area such as product development and finish product testing.

scholarly journals RP-HPLC-UV Method for Simultaneous Quantification of Second Generation Non-Steroidal Antiandrogens Along with their Active Metabolites in Mice Plasma: Application to a Pharmacokinetic Study

Drug Research ◽  
2018 ◽  
Vol 69 (10) ◽  
pp. 537-544
Author(s):  
Ashok Zakkula ◽  
Vinay Kiran ◽  
Umesh Todmal ◽  
Suresh P Sulochana ◽  
Ramesh Mullangi
Keyword(s):  
Pharmacokinetic Study ◽  
Active Metabolite ◽  
High Performance ◽  
Second Generation ◽  
Wave Length ◽  
Internal Standard ◽  
Hplc Method ◽  
Assay Method ◽  
Precipitation Process ◽  
Active Metabolites

AbstractA simple, specific and reproducible high-performance liquid chromatography (HPLC) assay method has been developed and validated for the quantitation of second generation antiandrogens and their active metabolites namely apalutamide, enzalutamide, N-desmethylenzalutamide (active metabolite of enzalutamide), darolutamide and ORM-15341 (active metabolite of darolutamide) in mice plasma. The method involves extraction of apalutamide, enzalutamide, N-desmethylenzalutamide, darolutamide and ORM-15341 along with internal standard (IS) from 100 µL mice plasma through a simple protein precipitation process. The chromatographic analysis was performed on a Waters Alliance HPLC system using a gradient mobile phase (comprising 10 mM ammonium acetate and acetonitrile in a flow-gradient) and X-Terra Phenyl column. The UV detection wave length was set at λmax 250 nm. Apalutamide, enzalutamide, N-desmethylenzalutamide, darolutamide and ORM-15341 and the IS eluted at 13.6, 11.4, 9.68, 6.11, 6.93 and 4.69 min, respectively with a total run time of 15 min. Method validation was performed as per regulatory guidelines and the results met the acceptance criteria. The calibration curve was linear over a concentration range of 209 – 5215 ng/mL (r 2=0.998). The intra- and inter-day precisions were in the range of 0.56–13.5 and 1.04–13.9%, respectively. The validated HPLC method was successfully applied to a pharmacokinetic study in mice.

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