Autonomous Underwater Glider (AUG) is a kind of unmanned underwater robot. Weight reduction is an effective measure to extend the duration performance and increase the carrying capacity of the AUG. In this paper, on the basis of the application of ANSYS-workbench, optimization for the structure and mass of the pressure hull of the AUG was conducted through the goal-driven optimization (GDO) method. After optimization, the total mass was reduced from 12.74 kg to 11.06 kg. The present work plays a key role for improving duration performance of AUG.