Hazardous wastes management in Brazil is a particularly difficult task to accomplish. The country's enormous area, the lack of tradition on dealing with this subject, few trained people, the high investment costs and the sophisticated technology involved make the regional management of hazardous wastes a mandatory approach to reduce costs and maximize benefits. In order to achieve this goal, a synoptic approach over an entire geographical region on all aspects of hazardous wastes management is proposed. On the other hand, several difficulties are foreseen, some of them in the socio-political arena, requiring a lot of an. environmental diplomacy and competent social communication in order to succeed. Despite the difficulties, there seem to be no options to deal with this problem when simultaneously considering its environmental, technical, and economic aspects.