Decision making with long delays using networks of flip-flop neurons

Author(s):  
Pavan Holla ◽  
Srinivasa Chakravarthy
Keyword(s):  
2019 ◽  
Author(s):  
Shashank Taxak ◽  
Uttam Pati

ABSTRACTSolid tumors require an efficient decision-making mechanism to progress through a gradient of hypoxia. Here, we show that an oxygen-sensory p53 tetramer-octamer switch makes cell decision for survival or death in variable hypoxia. Trapping homo-oligomers from biosynthesis cycle, we found a metastable p53 tetramer in cells. Under the operation of switch, tetramer segregates the p53 character of a tumor suppressor and promoter. The p53 switch generates a pattern of its on-off state in time that is specific to the strength of hypoxia. A bidirectional tetramer-octamer conversion in on state decides the restoration of basal state by forward and programs apoptosis upon the reverse shift via p53-MDM2 loop. However, reversible dimertetramer transitions in off state trigger chaperoning of HIF-1 complex by tetramer in forward and oncogenic gain-of-function by prion-like dimers in reverse direction. Temporal on-off patterns calibrate stabilized p53 pool by defining the abundance of dimer, tetramer and octamer that ultimately decides diverse cellular outcomes in hypoxia. Through multi-chromophore FRET, we further show that chaperoning of HIF-1 may modulate angiogenesis through a possible flip-flop of the p53T-HIF-1 complex upon DNA. Our results demonstrate how p53 can sense oxygen and act upon its homo-oligomerization states to control cell fate in hypoxic tumors.


2021 ◽  
Author(s):  
Sweta Kumari ◽  
Vigneswaran C ◽  
V. Srinivasa Chakravarthy

Sequential decision making tasks that require information integration over extended durations of time are challenging for several reasons including the problem of vanishing gradients, long training times and significant memory requirements. To this end we propose a neuron model fashioned after the JK flip-flops in digital systems. A flip-flop is a sequential device that can store state information of the previous history. We incorporate the JK flip-flop neuron into several deep network architectures and apply the networks to difficult sequence processing problems. The proposed architectures include flip-flop neural networks (FFNNs), bidirectional flip-flop neural networks (BiFFNNs), convolutional flip-flop neural networks (ConvFFNNs), and bidirectional convolutional flip-flop neural networks (BiConvFFNNs). Learning rules of proposed architectures have also been derived. We have considered the most popular benchmark sequential tasks like signal generation, sentiment analysis, handwriting generation, text generation, video frame prediction, lung volume prediction, and action recognition to evaluate the proposed networks. Finally, we compare the results of our networks with the results from analogous networks with Long Short-Term Memory (LSTM) neurons on the same sequential tasks. Our results show that the JK flip-flop networks outperform the LSTM networks significantly or marginally on all the tasks, with only half of the trainable parameters.


2008 ◽  
Vol 53 (No. 12) ◽  
pp. 531-538 ◽  
Author(s):  
J. Hron

This paper deals with the design of information architecture for the revitalisation of business processes. The proposal of a control system for a formalised decision-making process of revitalisation is in accordance with this information architecture. The entire methodology proposed relates to the application of consumer’s value renewal of the product. Experts’ standpoints are utilised in the procedural knowledge base which includes the information about the time sequence of starting and leaving some developmental activities. The product revitalisation control subsystem originates from this procedural knowledge base. The control subsystem converts this information into a binary format to enable detection of whether a consumer’s quality lies below/above the reference value and at that the procedural knowledge base also receives this reference value. The control process is based on a synthesis of sequential (logical) function, the self-control mechanism of experts’ decision-making (for the product value resumption regulation) is achieved via a reset-set (RS) flip-flop.


2021 ◽  
Author(s):  
Sweta Kumari ◽  
C Vigneswaran ◽  
V. Srinivasa Chakrava

Abstract Sequential decision making tasks that require information integration over extended durations of time are challenging for several reasons including the problem of vanishing gradients, long training times and significant memory requirements. To this end we propose a neuron model fashioned after the JK flip-flops in digital systems. A flip-flop is a sequential device that can store state information of the previous history. We incorporate the JK flip-flop neuron into several deep network architectures and apply the networks to difficult sequence processing problems. The proposed architectures include flip-flop neural networks (FFNNs), bidirectional flip-flop neural networks (BiFFNNs), convolutional flip-flop neural networks (ConvFFNNs), and bidirectional convolutional flip-flop neural networks (BiConvFFNNs). Learning rules of proposed architectures have also been derived. We have considered the most popular benchmark sequential tasks like signal generation, sentiment analysis, handwriting generation, text generation, video frame prediction, lung volume prediction, and action recognition to evaluate the proposed networks. Finally, we compare the results of our networks with the results from analogous networks with Long Short-Term Memory (LSTM) neurons on the same sequential tasks. Our results show that the JK flip-flop networks outperform the LSTM networks significantly or marginally on all the tasks, with only half of the trainable parameters.


2018 ◽  
Vol 41 ◽  
Author(s):  
Patrick Simen ◽  
Fuat Balcı

AbstractRahnev & Denison (R&D) argue against normative theories and in favor of a more descriptive “standard observer model” of perceptual decision making. We agree with the authors in many respects, but we argue that optimality (specifically, reward-rate maximization) has proved demonstrably useful as a hypothesis, contrary to the authors’ claims.


2018 ◽  
Vol 41 ◽  
Author(s):  
David Danks

AbstractThe target article uses a mathematical framework derived from Bayesian decision making to demonstrate suboptimal decision making but then attributes psychological reality to the framework components. Rahnev & Denison's (R&D) positive proposal thus risks ignoring plausible psychological theories that could implement complex perceptual decision making. We must be careful not to slide from success with an analytical tool to the reality of the tool components.


2018 ◽  
Vol 41 ◽  
Author(s):  
Kevin Arceneaux

AbstractIntuitions guide decision-making, and looking to the evolutionary history of humans illuminates why some behavioral responses are more intuitive than others. Yet a place remains for cognitive processes to second-guess intuitive responses – that is, to be reflective – and individual differences abound in automatic, intuitive processing as well.


2014 ◽  
Vol 38 (01) ◽  
pp. 46
Author(s):  
David R. Shanks ◽  
Ben R. Newell

2014 ◽  
Vol 38 (01) ◽  
pp. 48
Author(s):  
David R. Shanks ◽  
Ben R. Newell

Sign in / Sign up

Export Citation Format

Share Document