The article first analyses e-commerce new environment on medium manufacturing enterprise requires, current medium manufacturing enterprise achieved e-commerce has many difficult, should e-commerce correctly awareness, and full planning, and points step implementation, and e-commerce and enterprise integration, and construction features of e-commerce platform, and procurement and supply chain of collaborative management, and attention customer management, and variety e-commerce of mode mixed, and flexible effective operations, and logistics socialization, views, focus on small and medium manufacturing enterprises in e-commerce applications to be innovative in design, production and management of agile and flexible production strategies.