Methodological Comparisons of Heart Rate Variability Analysis in Patients With Type 2 Diabetes and Angiotensin Converting Enzyme Polymorphism

ABSTRACTObjective: Cardiac autonomic neuropathy (CAN) is a severe and common, yet highly underdiagnosed, complication of Type 2 diabetes mellitus(T2DM). Subclinical CAN may have reduced heart rate variability (HRV) but normal Ewing battery test. This study was performed to evaluate theimportance of 5 minutes HRV for the detection of autonomic dysfunction in T2DM without (CAN-T2DM).Methods: This cross-sectional observational study was conducted at the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU) on 30 recently diagnosed T2DM (RT2DM) and 54 long-term CAN-male T2DM patients (LT2DM), aged 45-55 years, from the EndocrinologyOut Patient Department of BSMMU, Dhaka. 30 age and body mass index matched apparently healthy male subjects were control. Ewing battery testwas used to rule out CAN positive T2DM. HRV data were recorded by a polyrite-D and analyzed by software. HRV was assessed by time domainmethod. For statistical analysis, ANOVA and unpaired t-test were used.Results: Mean RR, standard deviation of NN intervals (SDNN) (p<0.05), and root mean square of the successive differences (RMSSD) were significantly(p<0.001) lower, and mean HR and SDNN/RMSSD were (p<0.001) significantly higher in LT2DM compared to RT2DM and control. In addition, SDNNwas also significantly (p<0.05) lower in RT2DM than that of control.Conclusions: Results conclude that autonomic dysfunction may occur in both LT2DM and RT2DM patients without neuropathy and 5 minutes HRVtest is an important tool for detecting subclinical CAN.Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Heart rate variability.

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Heart rate variability analysis obtained from implantable cardioverter defibrillator: A new diagnostic tool

EP Europace ◽

10.1016/s1099-5129(01)80317-2 ◽

2001 ◽

Vol 2 ◽

pp. A79-A79

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Implantable Cardioverter Defibrillator ◽

Diagnostic Tool ◽

Heart Rate Variability Analysis ◽

Cardioverter Defibrillator ◽

Variability Analysis

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Heart Rate Variability Analysis in the Assessment of Autonomic Function in Heart Failure

10.21236/ada425014 ◽

2004 ◽

Author(s):

Marla J. De Jong ◽

David C. Randall

Keyword(s):

Heart Failure ◽

Heart Rate ◽

Heart Rate Variability ◽

Autonomic Function ◽

Heart Rate Variability Analysis ◽

Variability Analysis

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The influence of cardiac rehabilitation on heart rate variability indices in men with type 2 diabetes and coronary artery disease

Diabetes and Vascular Disease Research ◽

10.1177/14791641211020184 ◽

2021 ◽

Vol 18 (3) ◽

pp. 147916412110201

Author(s):

Katarzyna Szmigielska ◽

Anna Jegier

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Heart Rate ◽

Heart Rate Variability ◽

Coronary Artery ◽

Cardiac Rehabilitation ◽

Interval Training ◽

Patients With Diabetes ◽

Artery Disease

The study evaluated the influence of cardiac rehabilitation (CR) on heart rate variability (HRV) in men with coronary artery disease (CAD) with and without diabetes. Method: The study population included 141 male CAD patients prospectively and consecutively admitted to an outpatient comprehensive CR program. Twenty-seven patients with type-2 diabetes were compared with 114 males without diabetes. The participants performed a 45-min cycle ergometer interval training alternating 4-min workload and a 2-min active restitution three times a week for 8 weeks. The training intensity was adjusted so that the patient’s heart rate achieved the training heart rate calculated according to the Karvonen formula. At the baseline and after 8 weeks, all the patients underwent the HRV assessment. Results: HRV indices in the patients with diabetes were significantly lower as compared to the patients without diabetes in SDNN, TP, LF parameters, both at the baseline and after 8 weeks of CR. After 8 weeks of CR, a significant improvement of TP, SDNN, pNN50% and HF occurred in the patients without diabetes, whereas in the patients with diabetes only HF component improved significantly. Conclusions: As regards HRV indices, CR seems to be less effective in patients with CAD and type-2 diabetes.

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Heart Rate Variability Analyses in Parkinson’s Disease: A Systematic Review and Meta-Analysis

Brain Sciences ◽

10.3390/brainsci11080959 ◽

2021 ◽

Vol 11 (8) ◽

pp. 959

Author(s):

Konstantin G. Heimrich ◽

Thomas Lehmann ◽

Peter Schlattmann ◽

Tino Prell

Keyword(s):

Parkinson’S Disease ◽

Heart Rate ◽

Parkinson's Disease ◽

Heart Rate Variability ◽

Meta Analysis ◽

Cardiac Activity ◽

Heart Rate Variability Analysis ◽

Short Term ◽

Variability Analysis ◽

Parasympathetic Regulation

Recent evidence suggests that the vagus nerve and autonomic dysfunction play an important role in the pathogenesis of Parkinson’s disease. Using heart rate variability analysis, the autonomic modulation of cardiac activity can be investigated. This meta-analysis aims to assess if analysis of heart rate variability may indicate decreased parasympathetic tone in patients with Parkinson’s disease. The MEDLINE, EMBASE and Cochrane Central databases were searched on 31 December 2020. Studies were included if they: (1) were published in English, (2) analyzed idiopathic Parkinson’s disease and healthy adult controls, and (3) reported at least one frequency- or time-domain heart rate variability analysis parameter, which represents parasympathetic regulation. We included 47 studies with 2772 subjects. Random-effects meta-analyses revealed significantly decreased effect sizes in Parkinson patients for the high-frequency spectral component (HFms2) and the short-term measurement of the root mean square of successive normal-to-normal interval differences (RMSSD). However, heterogeneity was high, and there was evidence for publication bias regarding HFms2. There is some evidence that a more advanced disease leads to an impaired parasympathetic regulation. In conclusion, short-term measurement of RMSSD is a reliable parameter to assess parasympathetically impaired cardiac modulation in Parkinson patients. The measurement should be performed with a predefined respiratory rate.

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